Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba

Jyothi, D; Vanathi, P.; Gowri, P. Mangala; Rao, V. Rama Subba; Rao, J. Madhusudana; Sreedhar, Amere Subbarao

doi:10.1016/j.tiv.2009.05.023

Cited by 40 publications

(31 citation statements)

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“…showed no cytotoxic activity against MCF-7 cell lines (Portet et al, 2007); ethanol extract of Piper sarmentosum Roxb. inhibited HepG2 cells and nonmalignant Chang's liver cell lines (Ariffin et al, 2009); dichloromethane and methanol extracts from fruits of Piper nigrum L. and Piper chaba Hunter were inactive against C32 and HeLa cell lines (Atjanasuppat et al, 2009); although, E-piplartine isolated from roots of P. chaba showed cytotoxicity against several cell lines (BC-8, PCC4, P388S1, IMR32), significantly increased by curcumin (Jyothi et al, 2009). Essential oil from leaves of Piper gaudichaudianum Kunth was cytotoxic to Chinese hamster lung fibroblast (V79) cells (Péres et al, 2009).…”

Section: Discussionmentioning

confidence: 98%

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

Cruz¹,

Cáceres²,

Alvarez³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The essential oils from two native species from Guatemala were studied for their chemical composition and the dichloromethane and methanol extracts for their biological activity. A GC-MS analysis of the essential oil from Piper jacquemontianum Kunth, Piperaceae, showed 34 constituents, consisting mainly of linalool (69.4%), while Piper variabile C. DC. essential oil had 36 constituents, camphor (28.4%), camphene (16.6%) and limonene (13.9%) being the major components. Dichloromethane extracts of both species were cytotoxic against MCF-7, H-460 and SF-268 cell lines (<7 µg/mL). Dichloromethane extract of P. jacquemontianum was slightly active against bacteria (0.5 mg/mL), was active against promastigotes of Leishmania (20.4-61.0 µg/mL), and epimastigotes of Trypanosoma cruzi (51.9 µg/mL). The methanol extract of P. variabile showed antimalarial activity against Plasmodium falciparum F32 (4.5 µg/mL), and the dichloromethane extract against Leishmania (55.8-76.3 µg/mL) and T. cruzi (45.8 µg/mL). None of the extracts from the two species was active against Aedes aegypti larvae and Artemia salina nauplii.

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Section: Discussionmentioning

confidence: 98%

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

Cruz¹,

Cáceres²,

Alvarez³

et al. 2011

Rev. bras. farmacogn.

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“…The combined treatment of drug with natural compounds demonstrated [22,23] that the treatment potentiates drug toxicity, prevents the emergence of resistant strains and takes advantage of antibiotic synergism. Our combination treatment of drug with ampicillin and geldanamycin further demonstrated the potential anti-bacterial components present in P. betel fractions.…”

Section: Discussionmentioning

confidence: 99%

Anti–microbial principles of selected remedial plants from Southern India

Tirupathi

Suresh

Kumar

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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“…131 Data demonstrated the biological and medicinal importance of piplartine isolated from the roots of P. chaba, and indicated that E-piplartine may be a promising candidate for use in combinatorial treatments to combat cancer. 275 To date, the presence of 277 amides from Piper has been reported while data from chemical shifts in 13 C NMR is available for 182 compounds. From a phytochemical perspective, approximately 84% of species of Piper have not been investigated.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Occurrence, biological activities and 13C NMR data of amides from Piper (Piperaceae)

Nascimento¹,

Paula²,

David³

et al. 2012

Quím. Nova

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Recebido em 30/3/12; aceito em 24/7/12; publicado na web em 26/10/12 This manuscript describes an update review with up to 285 references concerning the occurrence of amides from a variety of species of the genus Piper (Piperaceae). Besides addressing occurrence, this review also describes the biological activities attributed to extracts and pure compounds, a compiled 13 C NMR data set, the main correlations between structural and NMR spectroscopic data of these compounds, and employment of hyphened techniques such as LC-MS, GC-MS and NMR for analysis of amides from biological samples and crude Piper extracts. Keywords: Piper;13 C NMR compilation; amides. INTRODUCTIONPiperaceae is one of the largest families among the basal Angiosperms, with approximately 3,000 species described to date. 1The family is currently divided into five genera: Macropiper, Zippelia, Piper, Peperomia and Manekia, 2 consisting of a wide variety of species found commonly around the world. Piper, Peperomia and Manekia occur in Brazil, mainly in the Amazonian and Atlantic forests. 3 Piper is the largest genus of this family, including more than 1,000 species, and can also be considered the largest genus of the basal angiosperms. 4 Amides are the major constituents of several species of Piper. Currently, they can be considered alkaloids in accordance with the modern definition by Pelletier.5 Natural amides can be classified as open-chain alkamides, aristolactams, 4,5-dioxoaporphines, ceramides, amides with pyrrolidine, piperidone and piperidine groups, cyclobutanamides and cyclohexanamides. The term piperamide is restricted to describe all compounds carrying an aromatic group and an amide group.In 1997, a review of this genus was published 6 dealing with chemical distribution and biological activities of amides. In the present review, an update with new chemical constituents of this genus is described and a compilation of 13 C NMR data and biological activities of these compounds are provided. Piper SPECIES, TRADITIONAL USES AND BIOLOGICAL ACTIVITIESDespite the large number of species of Piper, the use of these plants in folk medicine remains limited. One of the most well-known Piper Brazilian medicinal plants is P. corcovadensis, commonly found in North and Northeast regions, and popularly known as "João-brandinho". The leaves of this plant are used for the treatment of rheumatism in the form of poultice and infusions as well for flu and cough. In the Southeast region, the roots and branches of this specie are chewed to relieve toothache due to its anesthetic action on the mucous membrane. 7 In China, the use of leaves of P. futokasura is recommended in the treatment of cardiac arrhythmias and asthma. In Jamaica, stomach pains are treated with an infusion of leaves from P. aduncum and P. hispidum. Leaves from P. amalago are also employed in Mexico and Brazil for stomach pains and for the treatment of various infections. 8 Leaves and stems of P. marginatum and P. tuberculatum are used in Brazil, especially in Paraíba State (Brazil) agains...

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Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba

Cited by 40 publications

References 30 publications

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

Anti–microbial principles of selected remedial plants from Southern India

Occurrence, biological activities and 13C NMR data of amides from Piper (Piperaceae)

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