Diferencias en la presentación clínica y manejo terapéutico de la estenosis aórtica severa en mujeres en un centro de tercer nivel

Torres-Llergo, Javier; Fernández-Olmo, M. Rosa; Alania-Torres, Edgardo; Lozano-Cabezas, Cristóbal; Padilla-Pérez, Miriam; Fernández-Guerrero, Juan Carlos

doi:10.1016/j.carcor.2015.10.004

Cited by 2 publications

(1 citation statement)

References 16 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Women are usually older and have more severe symptoms than men at the time of diagnosis [ 11 , 12 ]. The literature provides varying conclusions regarding the correlation of female sex on early outcomes of surgical AVR [ 13 , 14 , 15 , 16 ], though most studies demonstrate a lower survival rate in women [ 12 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Does Gender Influence the Indication of Treatment and Long-Term Prognosis in Severe Aortic Stenosis?

Llopis

Serral

Torres

et al. 2023

JCDD

View full text Add to dashboard Cite

Introduction: It is a matter of controversy whether the therapeutic strategy for severe aortic stenosis (AS) differs according to gender. Methods: Retrospective study of patients diagnosed with severe AS (transvalvular mean gradient ≥ 40 mmHg and/or aortic valvular area <1 cm2) between 2009 and 2019. Our aim was to assess the association of sex on AVR or medical management and outcomes in patients with severe AS. Results: 452 patients were included. Women (51.1%) were older than men (80 ± 8.4 vs. 75.8 ± 9.9 years; p< 0.001). Aortic valve replacement (AVR) was performed less frequently in women (43.4% vs. 53.2%; p = 0.03), but multivariate analyses showed that sex was not an independent predictor factor for AVR. Age, Charlson index and symptoms were predictive factors (OR 0.81 [0.82–0.89], OR 0.81 [0.71–0.93], OR 22.02 [6.77–71.64]). Survival analysis revealed no significant association of sex within all-cause and cardiovascular mortalities (log-rank p = 0.63 and p = 0.07). Cox proportional hazards analyses showed AVR (HR: 0.1 [0.06–0.15]), Charlson index (HR: 1.13 [1.06–1.21]) and reduced LVEF (HR: 1.9 [1.32–2.73]) to be independent cardiovascular mortality predictors. Conclusions: Gender is not associated with AVR or long-term prognosis. Cardiovascular mortality was associated with older age, more comorbidity and worse LVEF.

show abstract

Section: Introductionmentioning

confidence: 99%

Does Gender Influence the Indication of Treatment and Long-Term Prognosis in Severe Aortic Stenosis?

Llopis

Serral

Torres

et al. 2023

JCDD

View full text Add to dashboard Cite

show abstract

Gender differences in incidence and in-hospital outcomes of surgical aortic valve replacement in Spain, 2001–15

López‐de‐Andrés

Méndez‐Bailón

Pérez-Farinós

et al. 2019

European Journal of Public Health

View full text Add to dashboard Cite

Background we aim to examine trends in the incidence of surgical aortic valve replacement (SAVR) among women and men in Spain from 2001 to 2015; compare in-hospital outcomes for mechanical and bioprosthetic SAVR by gender and; to identify factors associated with in-hospital mortality (IHM) after SAVR. Methods We performed a retrospective study using the Spanish National Hospital Discharge Database, 2001–15. We included patients that had SAVR as procedure in their discharge report. Propensity score matching (PSM) was performed to assess the impact of gender on the outcomes of mechanical and bioprosthetic SAVR. Results We identified 86 578 patients who underwent SAVR (40% women). Incidence of SVAR was higher in men (incidence rate ratio 1.57; 95%CI 1.55–1.59). In 2001, 73.36% of the men and 71.57% of women received a mechanical prosthesis; these proportions decreased to 43.04% in men and 35.89% in women in 2015, whereas bioprosthetic SAVR increased to 56.96% and 64.11%. After PSM we found that IHM was higher in women than in matched men for mechanical (8.94% vs. 6.79%; P < 0.001) and bioprosthetic (6.51 vs. 5.42%; P = 0.001) SAVR. The mean length of hospital stay was longer (19.54 vs. 18.74 days; P < 0.001) among females than males undergoing mechanical SAVR. Higher IHM after SAVR was associated with older age, comorbidities (except diabetes and atrial fibrillation), concomitant coronary artery bypass graft and emergency room admission. Conclusions This nation-wide analysis over 15 years of gender-specific outcomes after SAVR showed that, after PSM women have significantly higher IHM after mechanical and bioprosthetic SAVR than men.

show abstract

Diferencias en la presentación clínica y manejo terapéutico de la estenosis aórtica severa en mujeres en un centro de tercer nivel

Cited by 2 publications

References 16 publications

Does Gender Influence the Indication of Treatment and Long-Term Prognosis in Severe Aortic Stenosis?

Does Gender Influence the Indication of Treatment and Long-Term Prognosis in Severe Aortic Stenosis?

Gender differences in incidence and in-hospital outcomes of surgical aortic valve replacement in Spain, 2001–15

Contact Info

Product

Resources

About