Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome

Jacome‐Sosa, M. Miriam; Borthwick, Faye; Mangat, Rabban; Uwiera, Richard R. E.; Reaney, Martin J.T.; Shen, Jianheng; Quiroga, Ariel D.; Jacobs, René L.; Lehner, Richard; Proctor, Spencer D.

doi:10.1016/j.jnutbio.2014.02.011

Cited by 67 publications

(43 citation statements)

References 53 publications

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“…The differential amounts of c9,t11-CLA in the milk lipids also suggest that the dietary intervention was successful in changing the exposure of the lactating mammary epithelial cell to this potentially biologically active fatty acid. During the full-fat dairy intervention, there was also an elevation of other potentially biologically active, rumen-derived, fatty acids, including anteiso-15:0 and t11-18:1 [30][31][32], again strongly supporting dietary compliance of the subjects enrolled in this study.…”

Section: Discussionsupporting

confidence: 57%

Elevated dairy fat intake in lactating women alters milk lipid and fatty acids without detectible changes in expression of genes related to lipid uptake or synthesis

et al. 2015

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Section: Discussionsupporting

confidence: 57%

Elevated dairy fat intake in lactating women alters milk lipid and fatty acids without detectible changes in expression of genes related to lipid uptake or synthesis

et al. 2015

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“…In healthy men and women, diets high in vaccenic acid-rich butter did not affect body weight (241,242). In obese JCR:LA-cp rats, 1% dietary vaccenic acid supplementation reduced total body fat, stimulated adipose tissue redistribution (reduced mesenteric and increased inguinal fat mass) and decreased adipocyte size (243). However, in Zucker fatty rats, 1.5% (w/w) vaccenic acid for 8 weeks did not affect body weight or fat but decreased adipocyte size (244).…”

Section: Obesity Reviewsmentioning

confidence: 93%

Functional foods as potential therapeutic options for metabolic syndrome

2015

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Obesity as part of metabolic syndrome is a major lifestyle disorder throughout the world. Current drug treatments for obesity produce small and usually unsustainable decreases in body weight with the risk of major adverse effects. Surgery has been the only treatment producing successful long-term weight loss. As a different but complementary approach, lifestyle modification including the use of functional foods could produce a reliable decrease in obesity with decreased comorbidities. Functional foods may include fruits such as berries, vegetables, fibre-enriched grains and beverages such as tea and coffee. Although health improvements continue to be reported for these functional foods in rodent studies, further evidence showing the translation of these results into humans is required. Thus, the concept that these fruits and vegetables will act as functional foods in humans to reduce obesity and thereby improve health remains intuitive and possible rather than proven.

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“…dairy and beef fat). In rodent models of dyslipidemia, feeding dairy or beef fat enriched with BHI improved plasma lipoprotein profiles and insulin sensitivity (Bassett et al, 2010;Diane et al, 2016;Jacome-Sosa et al, 2014;Wang et al, 2010). Likewise, BHI-enriched beef or dairy fat exhibited anticarcinogenic activities both in vitro (De La Torre et al, 2006;Degen et al, 2011;O'Shea et al, 2000) and in vivo (Hubbard et al, 2006;Ip et al, 1999;Shiraishi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The Growth‐Inhibiting Effects of Beef Fatty Acids on MCF‐7 Cells Are Influenced Mostly by the Depot Location and Inconsistently by the Biohydrogenation Intermediate Content

Vahmani

Rolland

Gzyl

et al. 2018

Lipids

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Biohydrogenation intermediates (BHI) including conjugated linoleic acid (CLA) isomers are formed during ruminal biohydrogenation of polyunsaturated fatty acids (PUFA) in ruminants. Although many studies have examined the anticarcinogenic effects of CLA, few studies have reported the anticarcinogenic properties of BHI in their natural form found in dairy and beef fats. The present study compared the growth‐inhibitory effects of fatty acids from beef perirenal fat (PRF) or subcutaneous fat (SCF) with low or high levels of BHI in MCF‐7 human breast cancer cells. Cells were exposed for 72 h to media containing increasing doses (50 to 400 μM) of different beef fat treatments. Fatty‐acid analysis showed that BHI were readily incorporated into cell phospholipids (PL) in a treatment‐dependent manner, but higher BHI in PL did not consistently inhibit growth. Culturing with low‐BHI PRF or high‐BHI PRF did not lead to growth inhibition, but low‐BHI SCF inhibited growth, and inhibition was further increased by high‐BHI SCF. Other classes of fatty acids may, therefore, be interacting with BHI resulting in differential effects on growth inhibition in human breast cancer cells.

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Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome

Cited by 67 publications

References 53 publications

Elevated dairy fat intake in lactating women alters milk lipid and fatty acids without detectible changes in expression of genes related to lipid uptake or synthesis

Elevated dairy fat intake in lactating women alters milk lipid and fatty acids without detectible changes in expression of genes related to lipid uptake or synthesis

Functional foods as potential therapeutic options for metabolic syndrome

The Growth‐Inhibiting Effects of Beef Fatty Acids on MCF‐7 Cells Are Influenced Mostly by the Depot Location and Inconsistently by the Biohydrogenation Intermediate Content

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