Dietary α-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects

Zhao, Guixiang; Etherton, Terry D.; Martin, Keith R; Gillies, Peter J.; West, Sheila G.; Kris‐Etherton, Penny M.

doi:10.1093/ajcn/85.2.385

Cited by 285 publications

(230 citation statements)

References 42 publications

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“…As inflammation is associated with loss of muscle mass in the elderly and since dietary fat composition can influence inflammation, through stimulation of eicosanoid production, dietary fat may influence muscle loss (saturated and trans-fatty acids are considered pro-inflammatory and the n-3 and n-6 fatty acids, antiinflammatory) (105,212,(216)(217)(218)(219)(220)(221)(222)(223)(224)(225)(226)(227)(228) . Fatty acids are associated with insulin resistance in the same direction as inflammation (6,229) .…”

Section: Dietary Fat Compositionmentioning

confidence: 99%

Nutritional influences on age-related skeletal muscle loss

2013

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Age-related muscle loss impacts on whole-body metabolism and leads to frailty and sarcopenia, which are risk factors for fractures and mortality. Although nutrients are integral to muscle metabolism the relationship between nutrition and muscle loss has only been extensively investigated for protein and amino acids. The objective of the present paper is to describe other aspects of nutrition and their association with skeletal muscle mass. Mechanisms for muscle loss relate to imbalance in protein turnover with a number of anabolic pathways of which the mechanistic TOR pathway and the IGF-1-Akt-FoxO pathways are the most characterised.

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Section: Dietary Fat Compositionmentioning

confidence: 99%

Nutritional influences on age-related skeletal muscle loss

2013

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“…The anti-platelet, anti-inflammatory, and triglyceride-lowering effects of omega-3 fatty acids are seen with higher doses (3-4 g/d) of DHA + EPA, whereas the reduction in sudden cardiac death (SCD) risk can be achieved at lower intakes (0.5 to 1.0 g/d) [19,21]. Omega-3 fatty acids have been shown to have anti-inflammatory effects suppressing the production of cytokines such as interleukin-6, interleukin-1β, and tissue necrosis factor-α [22]. In a study by Noori et al [23].…”

Section: Benefits Of Omega-3 Fatty Acidsmentioning

confidence: 99%

Omega-3 Fatty Acids and Cardiovascular Disease

Lee¹

2013

J Marine Sci Res Dev

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Citation: Lee JH, Prasad A, Jarreau TK, O'Keefe JH, Milani R, et al. (2011) Omega-3 Fatty Acids and Cardiovascular Disease. J Marine Sci Res Development S1:001. doi:10.4172/2155-9910.S1-001Copyright: © 2011 Lee JH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Omega-3 fatty acids provides CV benefits through DHA and EPA enrichment of membrane phospholipids [9] which confers several potentially cardio-protective effects, including an increase arrhythmic thresholds [10], reduction in blood pressure [11,12], improved arterial and endothelial function [13], reduced platelet aggregation [14], and a favorable autonomic balance [11,15]. In a large population study of over 100,000 subjects, omega-3 fatty acid intake was shown to be inversely related to the development of type 2 diabetes in women [16]. A meta-analysis by Geleijnse et al. Omega-3 Fatty Acids and Cardiovascular Disease[17], of 22 double blind studies revealed that omega-3 fatty acid intake of about 4 g/d was associated with significant reductions of 1.7 and 1.5 mm Hg in systolic and diastolic pressures, respectively, an effect that was noted to be more pronounced in older patients and in those with higher baseline blood AbstractThe use of omega-3 fatty acids for the secondary prevention of cardiovascular (CV) events has been endorsed by the American Heart Association. A number of key epidemiologic and randomized trials have been the basis for this recommendation. Initially, the GISSI-Prevenzione and JELIS trials demonstrated significant reductions in CV events with the use of omega-3 fatty acids. More recently,the OMEGA, Alpha Omega, and Kowey et al.[37] studies examining omega-3 supplementation in atrial fibrillation have shown conflicting results. Although more recent trials have not shown the robust benefits that were seen in the earlier ones, the balance of evidence still favor the beneficial effects of omega-3 fatty acids. We would recommend the continuation of omega-3 fatty acids in patients with CV disease and in particular heart failure. Citation: Lee JH, Prasad A, Jarreau TK, O'Keefe JH, Milani R, et al. (2011) Omega-3 Fatty Acids and Cardiovascular Disease. J Marine Sci Res Development S1:001.

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“…Entre os principais mecanismos estudados, está o efeito protetor contra arritmias (115)(116) , efeitos no perfil lipídico (117)(118) , principalmente redução dos níveis séricos de triglicerídeos (119)(120)(121) , efeito antioxidante (122)(123)(124)(125) e antiinflamatório (126)(127) . Em 2001, dois estudos demonstraram evidênci-as sobre o efeito favorável dos ácidos graxos ômega-3 na redução do risco de DMRI.…”

Section: G Omega-3unclassified

“…Foi observada melhora da acuidade visual em 56,7% dos pacientes em uso do suplemento, manutenção em 20% e piora em 23,3% (133) . Outro autor (127) encontrou resultados opostos após 7 anos de seguimento de 254 indivíduos com DMRI precoce. Entre os tipos de gorduras examinadas, somente o consumo de ácidos graxos ômega-3 foi diretamente relacionado com a progressão da DMRI, definida como piora na comparação das fotos da região macular no momento inicial e após 7 anos.…”

Section: G Omega-3unclassified