Dietary zinc deficiency induced-changes in the activity of enzymes and the levels of free radicals, lipids and protein electrophoretic behavior in growing rats

Yousef, Mokhtar I.; Hendy, Hassan Abdel-Raouf El; El‐Demerdash, Fatma M.; El-Agamy, El-Sayed I.

doi:10.1016/s0300-483x(02)00049-5

Cited by 153 publications

(103 citation statements)

References 57 publications

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“…Also, vitamin B12 is involved in DNA synthesis [16]. The association between trace elements deficiency and G. intestinalis and E. vermicularis infection has scarcely been investigated and links are controversial [10,[13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Superoxide dismutase is a metalloenzyme capable of scavenging superoxide radicals by catalyzing their dismutation to reactive oxygen species. Reactive oxygen species can cause peroxidation of lipids leading to damage of membrane permeability, loss of enzyme activity, DNA damage leading to mutagenesis, carcinogenesis and apoptosis of cell [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Levels of Zinc, Copper, Magnesium Elements, and Vitamin B12, in Sera of Schoolchildren With Giardiasis and Entrobiosis in Kashan, Iran

Arbabi

Esmaili

Parastouei

et al. 2015

Zahedan J Res Med Sci

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Background: There are scant evidences between giardiasis and enterobiasis with human mal-absorption of micronutrient. Objectives: The aim of the present study was to found out the changes in the serum zinc, copper, magnesium and vitamin B12 levels in schoolchildren infected with Giardia intestinalis and Enterobius vermicularis. Patients and Methods: This case-control study was carried out among 359 children from aged 6 -12 years old at 8 suburban public schools. Three stool examinations were done using standard techniques for identification parasitic infection. Fifty E. vermicularis and 37 G. lamblia infected individuals were enrolled as study groups. Serum levels of copper, zinc, magnesium were assessed by autoanalyzer and vitamin B12 levels were measured using gamma counter. ANOVA and paired t-test analyses were used to determine the association between infections and trace elements changes. Results: The prevalence of G. intestinalis and E. vermicularis infections were 10.3% and 13.9%, respectively. The serum zinc, copper and magnesium levels showed a significant decrease in individuals infected with G. intestinalis and E. vermicularis (P < 0.05). Mean values of Giardia positive and negative groups for copper 143.65 ± 16.51 and 176.26 ± 17.6 μg/dL, zinc 62.26 ± 16.06 and 80.66 ± 23.58 μg/dL, and magnesium 1.82 ± 0.23 and 2.01 ± 0.16 mg/dL, respectively. Mean values of Enterobius positive and negative groups for copper 145.55 ± 26.84 and 176.26 ± 17.6 μg/dL, zinc 72.7 ± 17.92 and 80.66 ± 23.58 μg/dL and magnesium 1.93 ± 0.11 and 2.01 ± 0.16 mg/dL, respectively. Conclusions:The results showed that giardiasis and enterobiasis decreased serum levels of copper, zinc and magnesium. Further studies are needed to clarify the actual mechanism governing the zinc, copper, magnesium and vitamin B12 giardiasis/enterobiasis interaction.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Levels of Zinc, Copper, Magnesium Elements, and Vitamin B12, in Sera of Schoolchildren With Giardiasis and Entrobiosis in Kashan, Iran

Arbabi

Esmaili

Parastouei

et al. 2015

Zahedan J Res Med Sci

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“…Zinc (Zn) is an essential mineral and contributes several body protein and enzyme (3,38). So a number of biochemical processes need Zn (16,25) and Zn deficiency causes numerous metabolic or functional disorders.…”

Section: Introductionmentioning

confidence: 99%

Effects of oral zinc sulfate applications at different pH (ascorbic acid, vinegar of grapes and distillated water) on serum zinc levels in rabbits

Karademir

2011

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The oral zinc (Zn) applications may be required in the case of Zn losses in the body. Lots of Zn forms and compounds are used for this aim. Sulfate form of Zn is used in a widespread manner with in distillated water or other diluent solutions. The purpose of this study is to reveal the effect of some acidifier agents as diluent solutions (therapeutic dose of ascorbic acid in distillated water and pure vinegar of grapes) versus distillated water, well known and commonly used. Thirty New Zealand rabbits in three equal groups were used in this study. Zinc sulfate solutions with different diluents as above were given to groups orally. Before and after (2,5 hours later) oral applications, blood samples were collected via cardiac puncture under general diethyl ether anesthesia. Atomic absorption spectrometer equipped with flame system was employed. Significant differences (p≤0.001) were found between first and last serum Zn levels in all groups. There were also significant differences among last samples of groups (minimum p<0.05). Throughout the experiment time significant differences were found between control group and acidifier groups (ascorbic acid and vinegar of grapes) (p<0.05), but not between two acidifier groups (p>0.05). Significant correlation was detected between pH and serum Zn levels of oral solutions (r = -0.838, p<0.001). It was also observed that the oral solutions pH of ZnSO 4 influenced the serum Zn level significantly (r 2 : 70.1%, p<0.001). Consequently, the acidity of oral ZnSO 4 fortification solution affected the serum Zn level. While the pH level of oral ZnSO 4 solutions was decreasing, serum Zn level increased. The therapeutic dose of ascorbic acid in distillated water was more effective than pure vinegar of grapes Key words: Ascorbic Acid, serum Zn level, rabbit, vinegar of grapes, Zn fortification Tavşanlarda farklı pH'da (askorbik asit, üzüm sirkesi ve saf suya) oral çinko sülfat uygulamalarının serum çinko düzeyleri üzerine etkileri Özet: Vücutta çinko (Zn) kaybının olması durumunda oral Zn uygulamalarına gerek duyulabilir. Bu amaçla çok sayıda Zn formu veya bileşiği kullanılmaktadır. Zn'nin sülfat formu geniş çapta safsu veya diğer sulandırma solüsyonları ile birlikte yaygın bir şekilde kullanılmaktadır. Bu çalışmanın amacı, sulandırma solüsyonları halinde bazı asitleştirici ajanların (saf su içinde tedavi dozunda askorbik asit ve saf üzüm sirkesi) iyi bilinen ve yaygın bir şekilde kullanılan saf suya karşı etkisinin ortaya konmasıdır. Bu çalışmada üç eşit grup halinde 30 Yeni Zelanda ırkı tavşan kullanıldı. Yukarıda bahsedildiği gibi farklı sulandırmalar ile ZnSO 4 gruplara oral yolla verildi. Oral uygulama öncesi ve 2,5 saat sonrası dietil eter genel anestezisi altında kalpten kan örnekleri alındı. Alev sistemli atomik absorbsiyon spektrofotometre kullanıldı. Tüm gruplarda ilk ve son serum Zn düzeyleri arasındaki fark önemli bulundu (p≤0.001). Grupların son örneklerinin arasında da önemli farklılıklar vardı (en az p<0.05). Deney süresi boyunca kontrol grubu ve asit grupları (as...

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“…In our country, allowed Pb amount in fuel was 0.80 g/l in 1988, decreased to 0.21 g/l in 1998 and 0.13 g/l in 2009; and was decided to be Pb -free in 2012 [16]. Though Pb concentration in air has a downward trend since Pb free fuel consumption is improving, still Pb pollution is a serious environmental risk factor for especially children and pregnant women [1,17]. Determination of Pb amount in blood and tissue is the most valid method in Pb toxicity analysis [12,18].…”

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confidence: 99%

Lead analysis of air pollution in Istanbul utilizing by the vehicle cabin air filters

Alkan

Korpinar

2015

Med Sci and Discov

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Dietary zinc deficiency induced-changes in the activity of enzymes and the levels of free radicals, lipids and protein electrophoretic behavior in growing rats

Cited by 153 publications

References 57 publications

Levels of Zinc, Copper, Magnesium Elements, and Vitamin B12, in Sera of Schoolchildren With Giardiasis and Entrobiosis in Kashan, Iran

Levels of Zinc, Copper, Magnesium Elements, and Vitamin B12, in Sera of Schoolchildren With Giardiasis and Entrobiosis in Kashan, Iran

Effects of oral zinc sulfate applications at different pH (ascorbic acid, vinegar of grapes and distillated water) on serum zinc levels in rabbits

Lead analysis of air pollution in Istanbul utilizing by the vehicle cabin air filters

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