Dietary weight loss intervention provides improvement of gastroesophageal reflux disease symptoms—A randomized clinical trial

Valentini, Dirceu Felipe; Fernandes, Daieni; Campos, Vinícius Jardim; Mazzini, Guilherme S.; Gurski, Richard R

doi:10.1111/cob.12556

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The impact of obesity on global public health has grown in recent years. The basic pathogenesis of obesity includes either up-regulation of appetite or downregulation of calorie utilization by governing physical activity [30]. Additionally, obesity is related with metabolic disorders, inducing fatty liver and lipid metabolism disorders.…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

Park

Lee

et al. 2022

IJERPH

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Background: Chitoglucan (CG) is a bioactive component obtained from Flammulina velutipes Sing, an edible mushroom, which is known to have an anti-obesity effect. However, its biological and hormonal activities in alleviating obesity through regulation of adipocyte-derived proteins have not been examined yet. Purpose: The present study aimed to investigate the anti-obesity effects of chitoglucan and its hormonal mechanisms in high-fat diet (HFD)-induced mice. Methods: The mice were fed either a normal diet (Normal group) or a high fat diet (HFD group) over 6 weeks. The HFD fed mice were administered with saline (HFD group), adipex (HFD + adipex group), chitoglucan 50, 150, or 300 mg/kg/day for 3 weeks (HFD + CG groups). The food consumption, body weight, fat contents, and the levels of serum leptin and resistin were assessed after treatment of chitoglucan. Results: the HFD produced a marked increase in body and fat weights after 6 weeks of feeding compared with the Normal group. Administration of chitoglucan for 3 weeks tended to reduce body weight and significantly decreased parametrical adipose tissues in HFD groups. The level of serum leptin in the HFD group was markedly higher than that in the Normal group, whereas the level of leptin in the chitoglucan treated groups was significantly decreased in comparison with the HFD group. In addition, the level of serum resistin in high-fat diet group tended to be more increased than Normal group. However, the serum resistin level was significantly reduced in HF diet groups after treatment with chitoglucan (50 mg/kg or 150 mg/kg). Conclusion: Collectively, these data suggest that chitoglucan from the Flammulina velutipes may be useful in the treatment of high diet-induced obesity and metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

Park

Lee

et al. 2022

IJERPH

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Characteristics of psychosomatic disorders in patients with gastroesophageal reflux disease with concomitant obesity

Oparin¹,

Kashyrtseva²

2022

Shidnoevr. z. vnutr. simejnoi med.

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Purpose: To investigate the frequency and severity of psychosomatic disorders in patients with gastroesophageal reflux disease with comorbid obesity and patients with GERD without concomitant pathology, to evaluate the influence of psychoemotional state on the clinical picture of GERD. Materials and results. 90 patients and 20 practically healthy individuals took part in the study. The first group included GERD patients with accompanying obesity, the second group included GERD patients without accompanying pathology and the control group. Surveys were conducted using the GERDQ questionnaire, the severity of symptoms was assessed on a Likert scale. Psychoemotional status was assessed using the Dass-21 questionnaire, Spielberger State-Trait Anxiety Inventory, Beck Depression Inventory. Psychosomatic disorders of various degrees of severity were found in the majority of patients with GERD, and a direct relationship between the intensity of GERD symptoms and the level of psychosomatic disorders was noted.

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Optimization of gastroesophageal reflux disease treatment with concomitant obesity: new approaches and perspectives.

Oparin¹,

Kashyrtseva²

2023

Shidnoevr. z. vnutr. simejnoi med.

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In recent decades, there has been a rapid increase in obesity among the working-age population. Excess weight is associated with an elevated risk of developing gastrointestinal pathology, including gastroesophageal reflux disease (GERD). The aim of this study was to investigate the effectiveness and rationale for the addition of tyrosine-2-alanylglycyl-phenylalanyl-leucyl-arginine diacetate (dalarin) to the standard GERD treatment regimen. Materials and Methods: A total of 110 study participants were divided into two groups: 40 patients with GERD without concomitant obesity and 70 patients with GERD and grade I obesity. One group received the standard treatment protocol, while the other group received dalarin as an additional medication. Disease progression was assessed after a three-week period using clinical, laboratory, and instrumental examinations. Results: The results of clinical, laboratory, and instrumental examinations provide evidence that combined treatment with the inclusion of dalarin surpasses the effectiveness of the standard treatment protocol in both the isolated GERD group and the GERD group with concomitant obesity.

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Dietary weight loss intervention provides improvement of gastroesophageal reflux disease symptoms—A randomized clinical trial

Cited by 3 publications

References 36 publications

Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

Characteristics of psychosomatic disorders in patients with gastroesophageal reflux disease with concomitant obesity

Optimization of gastroesophageal reflux disease treatment with concomitant obesity: new approaches and perspectives.

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