In recent decades, there has been a rapid increase in obesity among the working-age population. Excess weight is associated with an elevated risk of developing gastrointestinal pathology, including gastroesophageal reflux disease (GERD). The aim of this study was to investigate the effectiveness and rationale for the addition of tyrosine-2-alanylglycyl-phenylalanyl-leucyl-arginine diacetate (dalarin) to the standard GERD treatment regimen. Materials and Methods: A total of 110 study participants were divided into two groups: 40 patients with GERD without concomitant obesity and 70 patients with GERD and grade I obesity. One group received the standard treatment protocol, while the other group received dalarin as an additional medication. Disease progression was assessed after a three-week period using clinical, laboratory, and instrumental examinations. Results: The results of clinical, laboratory, and instrumental examinations provide evidence that combined treatment with the inclusion of dalarin surpasses the effectiveness of the standard treatment protocol in both the isolated GERD group and the GERD group with concomitant obesity.
Purpose: To investigate the frequency and severity of psychosomatic disorders in patients with gastroesophageal reflux disease with comorbid obesity and patients with GERD without concomitant pathology, to evaluate the influence of psychoemotional state on the clinical picture of GERD. Materials and results. 90 patients and 20 practically healthy individuals took part in the study. The first group included GERD patients with accompanying obesity, the second group included GERD patients without accompanying pathology and the control group. Surveys were conducted using the GERDQ questionnaire, the severity of symptoms was assessed on a Likert scale. Psychoemotional status was assessed using the Dass-21 questionnaire, Spielberger State-Trait Anxiety Inventory, Beck Depression Inventory. Psychosomatic disorders of various degrees of severity were found in the majority of patients with GERD, and a direct relationship between the intensity of GERD symptoms and the level of psychosomatic disorders was noted.
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