Dietary treatment for familial hypercholesterolaemia

Poustie, Vanessa; Rutherford, Patricia

doi:10.1002/14651858.cd001918

Cited by 24 publications

(17 citation statements)

References 359 publications

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“…These recommendations can be implemented after 2 years of age, under the supervision of a dietician or nutritionist. The composition of fatty acids and cholesterol is an important aspect of the dietary recommendations made to the parents and the young HeFH patient [32]. Saturated fatty acids (SFAs), and above all palmitic acid, the most common SFA, present in dairy products, reduce the expression of the LDL receptor and increase the synthesis of VLDL (very-low-density lipoprotein).…”

Section: Basic Dietary Recommendationsmentioning

confidence: 99%

Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization

et al. 2011

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a b s t r a c tSince heterozygous familial hypercholesterolemia (HeFH) is a disease that exposes the individual from birth onwards to severe hypercholesterolemia with the development of early cardiovascular disease, a clear consensus on the management of this disease in young patients is necessary. In Belgium, a panel of paediatricians, specialists in (adult) lipid management, general practitioners and representatives of the FH patient organization agreed on the following common recommendations.

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Section: Basic Dietary Recommendationsmentioning

confidence: 99%

Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization

et al. 2011

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“…These individuals have higher TC and LDL-C and a 25-fold increased risk of developing premature CVD. Plasma TC and LDL-C concentrations in individuals who carry this mutation are relatively unresponsive to changes in the level or type of dietary fat [Poustie and Rutherford, 2001].…”

Section: Dietary Interactions With Genotypementioning

confidence: 99%

Fat and Fatty Acid Intake and Metabolic Effects in the Human Body

Sanders¹

2009

Ann Nutr Metab

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“…The effect of diet on LDL cholesterol levels is small [14] and not well documented in FH [15], but because the diet is recommended for life, cumulative effects of reducing the intake of saturated fat and cholesterol may be expected. Excessive fat restriction should be avoided [16].…”

Section: Treatmentmentioning

confidence: 99%

Management of hyperlipidemia in the pediatric population

Tonstad

Thompson²

2004

Curr Treat Options Cardio Med

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Heterozygous familial hypercholesterolemia (FH) affects one in every 500 persons and is the most common cause of markedly elevated cholesterol levels in children. Other causes of primary hyperlipidemia include familial combined hyperlipidemia, which is also common (approximately 1%) but not usually manifest until after puberty, and very rare genetic disorders that may lead to severe hypertriglyceridemia and chylomicronemia syndrome. In children with heterozygous FH, the short-term risk of clinical events is low; therefore, management starts with stratification of risk, followed by dietary modification, and in high-risk cases, pharmacologic treatment initiated after puberty. Male gender, a family history of premature coronary heart disease, and level of low-density lipoprotein (LDL) cholesterol above 4.9 mmol/L are important determinants of risk. Trials have shown that statins effectively lower LDL cholesterol levels; in one study, statins restored endothelial function, with no clinically adverse effects. The effects of statins for longer than 2 years have not been studied. The use of bile acid sequestrants (resins) is limited by compliance and side effects. Children with homozygous FH require expert management with LDL apheresis, high doses of effective statins, and cardiologic follow-up. Ezetimibe, the first in a new class of cholesterol absorption inhibitors, may provide additional efficacy in homozygous FH.

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Dietary treatment for familial hypercholesterolaemia

Cited by 24 publications

References 359 publications

Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization

Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization

Fat and Fatty Acid Intake and Metabolic Effects in the Human Body

Management of hyperlipidemia in the pediatric population

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