Dietary Total Antioxidant Capacity (TAC) Significantly Reduces the Risk of Site-Specific Cancers: An Updated Systematic Review and Meta-Analysis

Farhangi, Mahdieh Abbasalizad; Vajdi, Mahdi

doi:10.1080/01635581.2020.1771385

Cited by 18 publications

(13 citation statements)

References 78 publications

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“…The simultaneous effect of all the antioxidants in the body against free radicals is much stronger than the activity of an antioxidant alone 61. Recently, TAC levels have been assessed in several neoplastic conditions 62. In the present research, TAC levels in patients with leukemia were significantly lower than those in healthy participants and had a significant negative relationship with OC levels.…”

Section: Discussionmentioning

confidence: 42%

Organochlorine Pesticides, Oxidative Stress Biomarkers, and Leukemia: A Case-Control Study

Rafeeinia

Asadikaram

Karimi-Darabi

et al. 2022

Journal of Investigative Medicine

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Exposure to pesticides has been linked to an elevated risk of leukemia. The present research aimed to evaluate the relationship between organochlorine (OC) pesticides and biomarkers of oxidative stress in patients with leukemia. This work was conducted on 109 patients with leukemia and 109 healthy controls. The serum concentrations of seven derivatives of OCs including alpha-hexachlorocyclohexane (HCH), beta-HCH, gamma-HCH, 2,4-dichlorodiphenyltrichloroethane (DDT), 4,4-DDT, 2,4-dichlorodiphenyldichloroethylene (DDE), and 4,4-DDE along with acetylcholinesterase (AChE), glutathione peroxidase (GPx), superoxide dismutase (SOD), paraoxonase-1 (PON1), and catalase (CAT) activities as well as total antioxidant capacity (TAC), nitric oxide (NO), protein carbonyl (PC), and malondialdehyde (MDA) levels were measured in all the subjects. Levels of OCs were remarkably higher in patients with leukemia compared with the controls (p<0.05). In addition, levels of SOD, AChE, GPx, PON1, and TAC were remarkably lower in patients with leukemia compared with controls (p<0.05). In contrast, MDA, NO, and PC concentrations were higher in patients with leukemia than in the controls (p<0.05). Moreover, the serum level of 4,4-DDE was negatively associated with GPx activity (p=0.038). Our findings suggest that OCs may play a role in the development of leukemia by disrupting the oxidant/antioxidant balance.

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Section: Discussionmentioning

confidence: 42%

Organochlorine Pesticides, Oxidative Stress Biomarkers, and Leukemia: A Case-Control Study

Rafeeinia

Asadikaram

Karimi-Darabi

et al. 2022

Journal of Investigative Medicine

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“…61 Recently, TAC levels have been assessed in several neoplastic conditions. 62 In the present research, TAC levels in leukemia patients were significantly lower than those in healthy participants and had a significant negative relationship with OC levels. Contrary to our findings, Buico et al reported increased TAC levels in leukemia patients.…”

Section: Discussionsupporting

confidence: 41%

Organochlorine pesticides, oxidative stress biomarkers, and leukemia: a case–control study

Rafeeinia

Asadikaram

Darabi

et al. 2023

Journal of Investigative Medicine

View full text Add to dashboard Cite

Exposure to pesticides has been linked to an elevated risk of leukemia. The present research aimed to evaluate the relationship between organochlorine (OC) pesticides and biomarkers of oxidative stress in leukemia patients. This work was conducted on 109 patients with leukemia and 109 healthy controls. The serum concentrations of seven derivatives of OCs including alpha-HCH, beta-HCH, gamma-HCH, 2,4-DDT, 4,4-DDT, 2,4-DDE, and 4,4-DDE along with acetylcholinesterase (AChE), glutathione peroxidase (GPx), superoxide dismutase (SOD), paraoxonase-1 (PON1), and catalase (CAT) activities as well as total antioxidant capacity (TAC), nitric oxide (NO), protein carbonyl (PC), and malondialdehyde (MDA) levels were measured in all the subjects. Levels of OCs were remarkably higher in leukemia patients compared to the controls (p < 0.05). In addition, levels of SOD, AChE, GPx, PON-1, and TAC were remarkably lower in leukemia patients compared to controls (p < 0.05). In contrast, MDA, NO, and PC concentrations were higher in leukemia patients than in the controls (p < 0.05). Moreover, the serum level of 4,4-DDE was negatively associated with GPx activity (p = 0.038). Our findings suggest that OCs may play a role in the development of leukemia by disrupting the oxidant/antioxidant balance.

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“…In previous population studies, DTAC, measured by different methods, was inversely associated with prediabetes, insulin resistance, and diabetes [ 14 , 45 , 46 ], cancer [ 47 ], myocardial infarction [ 48 ], heart failure [ 49 ], and stroke [ 50 ]. In a large cross-sectional study, DTAC, measured by the FRAP method, was inversely associated with the hypertriglyceridemic waist phenotype and amputation due to arterial disease in people undergoing secondary care for CVDs [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

et al. 2022

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This study aimed to assess the relationship between the dietary total antioxidant capacity (DTAC) and the occurrence of cardiovascular diseases (CVDs), as well as healthy diet quality, in a representative sample (n = 5690) of the whole Polish adult population (WOBASZ II study). Daily food consumption was estimated by the single 24 h dietary recall method. Antioxidant vitamins (C, E, and β-carotene) and minerals (Zn, Fe, Mn, and Cu) from the diet and supplements were calculated using 5D Diet software, and dietary total polyphenol intake (DTPI) was determined using the Phenol-Explorer database and our database. Total diet quality was measured by the Healthy Diet Indicator (HDI) based on World Health Organization (WHO) recommendations for the prevention of CVD. DTAC was calculated using the data on food consumption and the antioxidant potential of foods measured by the FRAP (ferric ion reducing antioxidant potential) method. It was shown that higher DTAC was associated with a higher intake of polyphenols, antioxidant vitamins, and minerals. Moreover, a higher quartile of DTAC was associated with a reduced odds ratio for cardiovascular diseases in a Polish population, as well as with a higher HDI. Therefore, dietary recommendations for the prevention and therapy of CVDs should take into account a high DTAC. DTAC, measured by the FRAP method, can be considered an indicator of healthy diet quality.

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Dietary Total Antioxidant Capacity (TAC) Significantly Reduces the Risk of Site-Specific Cancers: An Updated Systematic Review and Meta-Analysis

Cited by 18 publications

References 78 publications

Organochlorine Pesticides, Oxidative Stress Biomarkers, and Leukemia: A Case-Control Study

Organochlorine Pesticides, Oxidative Stress Biomarkers, and Leukemia: A Case-Control Study

Organochlorine pesticides, oxidative stress biomarkers, and leukemia: a case–control study

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

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