Dietary total antioxidant capacity is related to glucose tolerance in older people: The Hertfordshire Cohort Study

Okubo, Hitomi; Syddall, H E; Phillips, David I. W.; Sayer, Avan A.; Dennison, Elaine; Cooper, Cyrus; Robinson, Siân

doi:10.1016/j.numecd.2013.08.001

Cited by 34 publications

(23 citation statements)

References 29 publications

(47 reference statements)

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“…In the Rotterdam Study, a prospective cohort that included 5,395 participants aged 55 years and older, dietary total antioxidant capacity of the diet did not seem to predict the risk of major neurologic diseases [32]. Other cohort studies have shown an inverse association between dietary total antioxidant capacity, diabetes [33] and metabolic syndrome [34].…”

Section: Regarding To Cardiovascular Disease the Results By Rautiainmentioning

confidence: 98%

Dietary total antioxidant capacity and mortality in the PREDIMED study

et al. 2015

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Section: Regarding To Cardiovascular Disease the Results By Rautiainmentioning

confidence: 98%

Dietary total antioxidant capacity and mortality in the PREDIMED study

et al. 2015

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“…Whereas, the longitudinal TLGS (Tehran Lipid and Glucose Study) showed that higher DTAC was positively associated with lower occurrence of MetS, abdominal obesity, and hypertension [ 19 ]. Findings of the Hertfordshire Cohort Study suggested that DTAC may have important protective effects on glucose tolerance, especially in older obese women [ 47 ]. A case-control study showed that higher dietary total antioxidant capacity is inversely related to prediabetes morbidity [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Total Antioxidant Capacity and Dietary Polyphenol Intake and Prevalence of Metabolic Syndrome in Polish Adults: A Nationwide Study

Zujko

Waśkiewicz

Witkowska

et al. 2018

Oxidative Medicine and Cellular Longevity

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Specific classes and subclasses of polyphenols have been studied for their potential effects on noncommunicable diseases, but studies on association between dietary polyphenol intake (DPI) and dietary total antioxidant capacity (DTAC) and MetS (metabolic syndrome) are scarce. Therefore, the aim of this study was to determine associations between DTAC and DPI and the prevalence of MetS and its components in the Polish adult population. Subjects (5690) were participants of the Polish National Multicentre Health Examination Survey (WOBASZ II study) performed in 2013-2014. MetS was defined according to the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) criteria. Daily food consumption was assessed by 24-hour dietary recall. DTAC and DPI were evaluated using the data of food consumption and antioxidant potential of foods, measured by FRAP (ferric reducing antioxidant potential) method, and total polyphenol content in foods, measured by Folin-Ciocalteu assay. Logistic regression models were used to assess the relationship between DTAC and DPI and MetS and its components. Crude, age-adjusted, and multivariable-adjusted models were performed. This study demonstrated that in Polish women, high DPI and high DTAC were significantly associated with a reduced odds ratio for the prevalence of MetS components, such as elevated blood pressure and diabetes. In contrast, in men, high DPI and high DTAC did not have the potential to alleviate MetS components.

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“…In line with this, a higher intake of certain nutrients with antioxidative properties has been associated with a lower risk of type 2 diabetes mellitus [5, 6]. In addition, serum levels of certain antioxidants have been shown to be inversely related to plasma glucose levels and measures of insulin resistance [7, 8]. However, the majority of previous studies on this topic have investigated individual antioxidant components only, as opposed to using a comprehensive measure of total dietary antioxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

Dietary antioxidant capacity and risk of type 2 diabetes mellitus, prediabetes and insulin resistance: the Rotterdam Study

et al. 2019

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Intake of individual antioxidants has been related to a lower risk of type 2 diabetes. However, the overall diet may contain many antioxidants with additive or synergistic effects. Therefore, we aimed to determine associations between total dietary antioxidant capacity and risk of type 2 diabetes, prediabetes and insulin resistance. We estimated the dietary antioxidant capacity for 5796 participants of the Rotterdam Study using a ferric reducing ability of plasma (FRAP) score. Of these participants, 4957 had normoglycaemia and 839 had prediabetes at baseline. We used covariate-adjusted proportional hazards models to estimate associations between FRAP and risk of type 2 diabetes, risk of type 2 diabetes among participants with prediabetes, and risk of prediabetes. We used linear regression models to determine the association between FRAP score and insulin resistance (HOMA-IR). We observed 532 cases of incident type 2 diabetes, of which 259 among participants with prediabetes, and 794 cases of incident prediabetes during up to 15 years of follow-up. A higher FRAP score was associated with a lower risk of type 2 diabetes among the total population (HR per SD FRAP 0.84, 95% CI 0.75; 0.95) and among participants with prediabetes (HR 0.85, 95% CI 0.73; 0.99), but was not associated with risk of prediabetes. Dietary FRAP was also inversely associated with HOMA-IR (β − 0.04, 95% CI − 0.06; − 0.03). Effect estimates were generally similar between sexes. The findings of this population-based study emphasize the putative beneficial effects of a diet rich in antioxidants on insulin resistance and risk of type 2 diabetes.Electronic supplementary materialThe online version of this article (10.1007/s10654-019-00548-9) contains supplementary material, which is available to authorized users.

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Dietary total antioxidant capacity is related to glucose tolerance in older people: The Hertfordshire Cohort Study

Abstract: These findings suggest dietary TAC may have important protective effects on glucose tolerance, especially in older obese women.

Cited by 34 publications

References 29 publications

Dietary total antioxidant capacity and mortality in the PREDIMED study

Dietary total antioxidant capacity and mortality in the PREDIMED study

Dietary Total Antioxidant Capacity and Dietary Polyphenol Intake and Prevalence of Metabolic Syndrome in Polish Adults: A Nationwide Study

Dietary antioxidant capacity and risk of type 2 diabetes mellitus, prediabetes and insulin resistance: the Rotterdam Study

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