Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective

Panyod, Suraphan; Ho, Chi Tang; Sheen, Lee‐Yan

doi:10.1016/j.jtcme.2020.05.004

Cited by 221 publications

(182 citation statements)

References 39 publications

Supporting

Mentioning

161

Contrasting

Unclassified

Order By: Relevance

“…A balanced diet and dietary intake of nutrients affect the immune system through gene expression, cell activation and modification of signaling molecules. In addition, various food ingredients are determinants of the gut microbial composition and subsequently form immune responses in the body [ 138 , 139 , 140 ]. A diet combined with medicinal plants with immunomodulatory, antiviral and anti-inflammatory effects can significantly enhance this protection.…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

View full text Add to dashboard Cite

The development of new effective anti-coronavirus drugs and therapies is important, but it requires significant human, financial and, most importantly, time expenditures. The current pandemic is neither the first nor the last. Humanity has already accumulated considerable survival experience. We cannot do without prevention and epidemiological protection measures. This study reviews medicinal plants that grow in Northeast Asia and whose antioxidant, antiviral, anti-inflammatory and immunomodulatory characteristics are already known, also in the framework of the prevention and treatment of pneumonia of various etiologies. The need for a comprehensive approach to maintaining immunodefences, including functional foods and positive emotions, is emphasized. In the period of pandemics, it is important to research various areas that allow to us accumulate a critical mass of information and cope with the next global disease.

show abstract

Section: Resultsmentioning

confidence: 99%

Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

View full text Add to dashboard Cite

show abstract

“…For example, Hensel et al (2020), in their recent work, state that extracts prepared with Echinacea species (Asteraceae) have an important role with the immune system due to their alkylamide interacting with the cannabinoid receptors (Hensel et al, 2020). Additionally, curcumin, the main constituent in Curcuma longa L. (Zingiberaceae), is suggested as a potential clinical option for the treatment of SARS-CoV-2 infection, due to its action in several steps of a viral infection such as protease inhibition, cellular signalling pathways modulation, among others (Zahedipour et al, 2020) In another paper (Panyod et al, 2020), 11 medicinal plants were discussed concerning their in vitro antiviral activity using different models. Two species (Allium sativum L. and Zingiber officinale Roscoe) mentioned in this study that had their in vitro potential and immune capacity assessed, were also included in our study.…”

Section: Preventative and Therapeutic Approachesmentioning

confidence: 99%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

View full text Add to dashboard Cite

Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method: The plant selection was primarily based on species listed by the WHO and EMA, but some other herbal remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical data on their efficacy and safety were collected from authoritative sources. The target population were adults with early and mild flu symptoms without underlying conditions. These were evaluated according to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The benefits/risks balance of the treatments was classified as positive, promising, negative, and unknown. Results: A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases (Allium sativum, Andrographis paniculata, Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulus essential oil, Justicia pectoralis, Magnolia officinalis, Mikania glomerata, Pelargonium sidoides, Pimpinella anisum, Salix sp, Zingiber officinale), and unknown for the rest. On the same grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. Conclusions: Our work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical

show abstract

“…Moreover, an estimated 28,187 plant taxa, globally, are documented to have medicinal values, with over 3000 species reported with the ethnomedicinal application against cancer [ 3 , 4 ]. The continued dependence of mankind on plants was further evidenced during the recent outbreak of the COVID-19 pandemic, whereby herbal medicines were used in an attempt to mitigate the symptoms of the novel coronavirus infection [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest

Rummun

Rondeau²,

Bourdon³

et al. 2020

Pharmaceuticals

View full text Add to dashboard Cite

Tropical forests constitute a prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remain unexplored. The scarcity of rigorous scientific data on the surviving Mascarene endemic taxa renders bioprospecting of this untapped resource of utmost importance. Thus, in view of valorizing the native resource, this study has as its objective to investigate the bioactivities of endemic leaf extracts. Herein, seven Mascarene endemic plants leaves were extracted and evaluated for their in vitro antioxidant properties and antiproliferative effects on a panel of cancer cell lines, using methyl thiazolyl diphenyl-tetrazolium bromide (MTT) and clonogenic cell survival assays. Flow cytometry and comet assay were used to investigate the cell cycle and DNA damaging effects, respectively. Bioassay guided-fractionation coupled with liquid chromatography mass spectrometry (MS), gas chromatography-MS, and nuclear magnetic resonance spectroscopic analysis were used to identify the bioactive compounds. Among the seven plants tested, Terminaliabentzoë was comparatively the most potent antioxidant extract, with significantly (p < 0.05) higher cytotoxic activities. T. bentzoë extract further selectively suppressed the growth of human hepatocellular carcinoma cells and significantly halted the cell cycle progression in the G0/G1 phase, decreased the cells’ replicative potential and induced significant DNA damage. In total, 10 phenolic compounds, including punicalagin and ellagic acid, were identified and likely contributed to the extract’s potent antioxidant and cytotoxic activities. These results established a promising basis for further in-depth investigations into the potential use of T. bentzoë as a supportive therapy in cancer management.

show abstract

Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective

Cited by 221 publications

References 39 publications

Medicinal Plants to Strengthen Immunity during a Pandemic

Medicinal Plants to Strengthen Immunity during a Pandemic

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest

Contact Info

Product

Resources

About