Dietary supplements for children with Down syndrome: exploration of current use and scientific evidence : Fieldwork and literature study

Haar, Sandra van der; Zeinstra, Gertrude G.

doi:10.18174/554328

Cited by 1 publication

(2 citation statements)

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“…Nonetheless, the use of various products that supposedly improve health and intellectual functions has continued to increase (Ani et al . 2000; Ergović & Obradović 2021; van der Haar & Zeinstra 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Although advances in metabolic disorder research and targeted pharmacological treatment have improved certain comorbidities and life expectancy in children/adolescents with DS, no therapeutic options have significantly improved their intellectual abilities (de Graaf et al 2017;Dierssen et al 2020;Hendrix et al 2021). Nonetheless, the use of various products that supposedly improve health and intellectual functions has continued to increase (Ani et al 2000;Ergović & Obradović 2021;van der Haar & Zeinstra 2021).…”

Section: Introductionmentioning

confidence: 99%

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Micronutrient status in children and adolescents with Down syndrome: systematic review and meta‐analysis

Barišić

Ravančić

Majstorović

et al. 2023

J intellect Disabil Res

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Background Down syndrome (DS) is the most common genetic disorder. To date, the scientific literature regarding micronutrient status in children and adolescents with DS has not been systematically reviewed. Therefore, our aim was to provide a systematic review and meta-analysis on this topic. Methods We identified all relevant case-control studies published by 1 January 2022, by searching the PubMed and Scopus databases for original English-language articles analysing the micronutrient status of individuals with DS. Forty studies were included in the systematic review and 31 in the metaanalysis.Results Statistically significant differences between individuals with DS (cases) and non-DS (controls) (P ≤ 0.05) were obtained for zinc, selenium, copper, vitamin B12, sodium and calcium. Serum, plasma and whole blood analyses showed lower zinc levels in cases than controls {standardised mean difference [SMD] serum [95% confidence interval (CI)] = À2.32 [À3.22, À1.41], P < 0.00001; SMD plasma [95% CI] = À1.29 [À2.26, À0.31], P < 0.01; SMD blood [95% CI] = À1.59 [À2.29, À0.89], P < 0.00001}. Similarly, plasma and blood selenium concentrations were significantly lower in cases than controls (SMD plasma [95% CI] = À1.39 [À2.26, À0.51], P = 0.002; SMD blood [95% CI] = À1.86 [À2.59, À1.13], P < 0.00001). Intraerythrocytic copper and serum B12 were higher in cases than controls (SMD Cu [95% CI] = 3.33 [2.19, 4.46], P < 0.00001; SMD B12 [95% CI] = 0.89 [0.01, 1.77], P = 0.048). Blood calcium was lower in cases than controls (SMD Ca [95% CI] = À0.77 [À1.34, À0.21], P = 0.007).Conclusions This study provides the first systematic overview of micronutrient status in children and adolescents with DS and has shown that relatively little consistent research has been executed in this field. There is a clear need for more well-designed, clinical trials to study the micronutrient status and effects of dietary supplements in children and adolescents with DS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Micronutrient status in children and adolescents with Down syndrome: systematic review and meta‐analysis

Barišić

Ravančić

Majstorović

et al. 2023

J intellect Disabil Res

View full text Add to dashboard Cite

show abstract

Dietary supplements for children with Down syndrome: exploration of current use and scientific evidence : Fieldwork and literature study

Abstract: Project executionSandra van der Haar, Gertrude Zeinstra (WFBR)With support from Wageningen University students:

Cited by 1 publication

References 73 publications

Micronutrient status in children and adolescents with Down syndrome: systematic review and meta‐analysis

Micronutrient status in children and adolescents with Down syndrome: systematic review and meta‐analysis

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