Dietary supplementation with monosodium glutamate is safe and improves growth performance in postweaning pigs

Abstract

Dietary intake of glutamate by postweaning pigs is markedly reduced due to low feed consumption. This study was conducted to determine the safety and efficacy of dietary supplementation with monosodium glutamate (MSG) in postweaning pigs. Piglets were weaned at 21 days of age to a corn and soybean meal-based diet supplemented with 0, 0.5, 1, 2, and 4 % MSG (n = 25/group). MSG was added to the basal diet at the expense of cornstarch. At 42 days of age (21 days after weaning), blood samples (10 mL) were obtained from the jugular vein of 25 pigs/group at 1 and 4 h after feeding for hematological and clinical chemistry tests; thereafter, pigs (n = 6/group) were euthanized to obtain tissues for histopathological examinations. Feed intake was not affected by dietary supplementation with 0-2 % MSG and was 15 % lower in pigs supplemented with 4 % MSG compared with the 0 % MSG group. Compared with the control, dietary supplementation with 1, 2 and 4 % MSG dose-dependently increased plasma concentrations of glutamate, glutamine, and other amino acids (including lysine, methionine, phenylalanine and leucine), daily weight gain, and feed efficiency in postweaning pigs. At day 7 postweaning, dietary supplementation with 1-4 % MSG also increased jejunal villus height, DNA content, and antioxidative capacity. The MSG supplementation dose-dependently reduced the incidence of diarrhea during the first week after weaning. All variables in standard hematology and clinical chemistry tests, as well as gross and microscopic structures, did not differ among the five groups of pigs. These results indicate that dietary supplementation with up to 4 % MSG is safe and improves growth performance in postweaning pigs.

Use of Cross-Fostering to Enhance Growth of Pigs That Are Predicted to Grow Poorly Based on Plasma α-1 Acid Glycoprotein Concentration

“…Liquid milk replacer was prepared by diluting milk replacer powder (94.0% dry matter) 1:5 with warm water (dry matter 18.8%). This is similar to the dry matter content (18.6%) reported for sow's milk on d 7 -21 of lactation [15].…”

Biochemical Changes in Fatty Acids, Hydrocarbons and Sterols as well as Total Lipids of Albino Rats Ingested some Synthetic Colourants and Flavourants as Food Additives

“…Also, these results are paralleled with the results of Abdel-Rahim et al (1989) who found that, synthetic 43 colourants influenced as hypocholesterolemic and hypolipimic agents. The same observation was reported by Abdel-Rahim et al (1995), since they concluded that, total lipids and total cholesterol of blood were decreased by ingestion of synthetic colourants as food additives (Shi et al, 2010;Rezaei et al, 2013).…”

Within-litter variation in birth weight: impact of nutritional status in the sow

“…Sows fed a basal gestational diet supplemented with mixture of 8 g L-arginine and 12 g L-glutamine had reduced withinlitter variation in birth weight either on the basis of total piglets or live-born piglets, and the proportion of runt piglets was decreased. It would be of interest to determine whether dietary supplementation with L-glutamate, which is the immediate precursor of L-glutamine (Rezaei et al, 2013b) and is another functional amino acid (Wu, 2010), can enhance fetal growth and reduce birth-weight variation among piglets.…”