Dietary supplementation with copper nanoparticles influences the markers of oxidative stress and modulates vasodilation of thoracic arteries in young Wistar rats

Majewski, Michał; Lis, Bernadetta; Olas, Beata; Ognik, Katarzyna; Juśkiewicz, Jerzy

doi:10.1371/journal.pone.0229282

Cited by 16 publications

(19 citation statements)

References 34 publications

(45 reference statements)

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“…A similar effect was also observed in Sprague–Dawley rats that were given copper nanoparticle synthetized from Cistus incanus [ 48 ]. Although some studies suggest that copper nanoparticles at low doses work as a cardioprotectant against myocardial infarction [ 51 ], high amounts of copper can cause oxidative stress and injure heart muscles [ 48 , 52 ]. Copper nanoparticles works by inducing lysosomal dysfunction which causes irreversible oxidation of proteins, lipids, and nucleic acids, consequently triggering DNA damage and cell death leading to impairment of heart muscle contractility [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Co-Treatment of Copper Oxide Nanoparticle and Carbofuran Enhances Cardiotoxicity in Zebrafish Embryos

Saputra

Uapipatanakul

Lee

et al. 2021

IJMS

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The use of chemicals to boost food production increases as human consumption also increases. The insectidal, nematicidal and acaricidal chemical carbofuran (CAF), is among the highly toxic carbamate pesticide used today. Alongside, copper oxide nanoparticles (CuO) are also used as pesticides due to their broad-spectrum antimicrobial activity. The overuse of these pesticides may lead to leaching into the aquatic environments and could potentially cause adverse effects to aquatic animals. The aim of this study is to assess the effects of carbofuran and copper oxide nanoparticles into the cardiovascular system of zebrafish and unveil the mechanism behind them. We found that a combination of copper oxide nanoparticle and carbofuran increases cardiac edema in zebrafish larvae and disturbs cardiac rhythm of zebrafish. Furthermore, molecular docking data show that carbofuran inhibits acetylcholinesterase (AChE) activity in silico, thus leading to impair cardiac rhythms. Overall, our data suggest that copper oxide nanoparticle and carbofuran combinations work synergistically to enhance toxicity on the cardiovascular performance of zebrafish larvae.

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Section: Discussionmentioning

confidence: 99%

Co-Treatment of Copper Oxide Nanoparticle and Carbofuran Enhances Cardiotoxicity in Zebrafish Embryos

Saputra

Uapipatanakul

Lee

et al. 2021

IJMS

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“…During pathological conditions (hypertension, diabetes, aging, malnutrition, or hypercholesterolemia) endothelial dysfunction exists [ 34 , 35 , 36 , 37 ]. This may include reduced NO bioavailability and an increase of vasoconstrictor factors which alter NOS and COX activities and the vasodilator response of isolated arteries.…”

Section: Discussionmentioning

confidence: 99%

“…In hypertensive rats, the vasodilation was reduced to a similar level in both supplemented and nonsupplemented rats. In healthy states, the expression of iNOS is absent [ 35 ]. Rather it occurs under inflammatory conditions as was observed in control hypertensive rats.…”

Section: Discussionmentioning

confidence: 99%

The Characterization of Ground Raspberry Seeds and the Physiological Response to Supplementation in Hypertensive and Normotensive Rats

et al. 2020

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This study aimed to evaluate the protective role of ground raspberry seeds (RBS) as a source of polyphenols and essential fatty acids on blood plasma enzymatic antioxidant status, lipid profile, and endothelium-intact vasodilation during physiological and pathological conditions. Young normotensive Wistar–Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) at ten weeks of age were fed with either a control diet or were supplemented with added 7% RBS for six weeks (n = 6). The main component of RBS was dietary fiber (64%) and the main polyphenols were ellagitannins (1.2%) and flavan-3-ols (0.45%). Irrespective of the rat model, ground RBS decreased liver enzyme aspartate aminotransferase (0.9-fold) and hydrogen peroxide scavenging capacity (Catalase, 0.9-fold). In supplemented SHRs, preincubation with inducible nitric oxide synthase (iNOS) inhibitor 1400W, nonselective cyclooxygenase (COX) inhibitor indomethacin, selective COX-2 inhibitor NS-398, prostacyclin (PGI2) synthesis inhibitor tranylcypromine (TCP), thromboxane receptor (TP) antagonist SQ-29548, thromboxane synthesis inhibitor furegrelate, and 20-HETE synthesis inhibitor HET0016 induced the same relaxant response to acetylcholine as in the nonsupplemented control group. In supplemented WKYs, atherogenic index was decreased (0.8-fold), while iNOS and COX-2-derived PGI2 increased acetylcholine-induced vasodilation. These effects of ground RBS may constitute a potential mechanism for preventing cardiovascular diseases.

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“…The rats were individually housed in plastic cages under a controlled environment (a 12 h light–dark cycle, a temperature of 21 ± 1 °C, relative humidity of 50–70%, and 20 air changes per hour) [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

“…An increased contribution of plant-based food is one of the ways to prevent obesity and associated metabolic disorders, which is partly due to the relatively low caloric value of such food [4]. However, food from plants is also a good source of bioactive compounds that can directly bring benefits to the cardiovascular system, a good example of which are polyunsaturated fatty acids (PUFAs) with α-linolenic acid and linoleic acid as their main Nutrients 2021, 13, 2575. https://doi.org/10.3390/nu13082575 https://www.mdpi.com/journal/nutrients Nutrients 2021, 13, 2575 2 of 14 representatives in nature [5]. Besides their nutritional importance, these PUFAs, especially from the n-3 family, can improve lipid metabolism and the inhibition of lipid synthesis in the body [6,7].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Hemp (Cannabis sativa L.) Seeds and Hemp Seed Oil on Vascular Dysfunction in Obese Male Zucker Rats

Majewski

Jurgoński

2021

Nutrients

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Seeds of industrial hemp (Cannabis sativa L.) contain a large amount of protein (26.3%), dietary fiber (27.5%), and fatty acids (33.2%), including linoleic, α-linolenic, and some amount of γ-linolenic acid. In our study, obese male Zucker rats (n = 6) at 8 weeks of age were supplemented for a further 4 weeks with either ground hemp seeds (12% diet) or lipid fractions in the form of hemp seed oil (4% diet). Hemp oil decreased blood plasma HDL-cholesterol (x0.76, p ≤ 0.0001), triglycerides (x0.55, p = 0.01), and calculated atherogenic parameters. Meanwhile, hemp seeds decreased HDL-cholesterol (x0.71, p ≤ 0.0001) and total cholesterol (x0.81, p = 0.006) but not the atherogenic index. The plasma antioxidant capacity of water-soluble compounds was decreased by the seeds (x0.30, p = 0.0015), which in turn was associated with a decrease in plasma uric acid (x0.18, p = 0.03). Dietary hemp seeds also decreased plasma urea (x0.80, p = 0.02), while the oil decreased the plasma total protein (x0.90, p = 0.05). Hemp seeds and the oil decreased lipid peroxidation in the blood plasma and in the heart (reflected as malondialdehyde content), improved contraction to noradrenaline, and up-regulated the sensitivity of potassium channels dependent on ATP and Ca2+. Meanwhile, acetylcholine-induced vasodilation was improved by hemp seeds exclusively. Dietary supplementation with ground hemp seeds was much more beneficial than the oil, which suggests that the lipid fractions are only partially responsible for this effect.

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Dietary supplementation with copper nanoparticles influences the markers of oxidative stress and modulates vasodilation of thoracic arteries in young Wistar rats

Cited by 16 publications

References 34 publications

Co-Treatment of Copper Oxide Nanoparticle and Carbofuran Enhances Cardiotoxicity in Zebrafish Embryos

Co-Treatment of Copper Oxide Nanoparticle and Carbofuran Enhances Cardiotoxicity in Zebrafish Embryos

The Characterization of Ground Raspberry Seeds and the Physiological Response to Supplementation in Hypertensive and Normotensive Rats

The Effect of Hemp (Cannabis sativa L.) Seeds and Hemp Seed Oil on Vascular Dysfunction in Obese Male Zucker Rats

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