Dietary supplementation with Bacillus subtilis promotes growth performance of broilers by altering the dominant microbial community

Zhang, Shan; Guang, Zhong; Shao, Dan; Wang, Qiang; Hu, Yan; Wu, Tianxing; Ji, Chaojin; Shi, Shourong

doi:10.1016/j.psj.2020.12.032

Cited by 89 publications

(70 citation statements)

References 68 publications

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“…Likewise, a similar production performance was observed between PB and AGP groups at both 28 and 35 d of age ( Table 2 , Table 3 , Table 4 ), significantly higher ( P ˂ 0.05) than the CO group. Our results resemble those reported by other researchers using other B. subtilis strains ( Sikandar et al., 2017 ; Teo and Tan, 2007 ; Park et al., 2020 ; Zhang et al., 2021 ). Moreover, in our trial, EEF results were similar between AGP and PB groups, which is highly relevant because it includes all indicators of zootechnical importance and is in agreement with previous results ( Fritts et al., 2000 ; Opalinski et al., 2007 ; Bitterncout et al., 2011 ; Knap et al., 2011 ; Jayaraman et al., 2017 ; Manafi et al., 2017 ; Krueger et al., 2020 ).…”

Section: Discussionsupporting

confidence: 92%

“…The intestinal segments were dehydrated in an ascending gradient of ethanol. These samples were then cleaned in xylene, embedded in paraffin wax, processed into slices, stained with hematoxylin and eosin ( Zhang et al., 2021 ), and observed under a light microscope. Ten villi in each sample (2 sections) were randomly selected (30 villi per replicate; therefore 150 villi per treatment) and measured using an Olympus trinocular microscope BX53, DF73 digital camera, and CellSens Entry CS Photography Program.…”

Section: Methodsmentioning

confidence: 99%

“…The current population shows great interest in food safety and security. In addition, many governments create laws and regulations that regulate the use of antibiotics ( Zhang et al., 2021 ), so the poultry industry is focused on looking for alternatives to antibiotics that maintain the performance and health of animals in productive conditions ( Ciurescu et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of the use of probiotic Bacillus subtilis (QST 713) as a growth promoter in broilers: an alternative to bacitracin methylene disalicylate

2021

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The global poultry trend toward the more responsible use of antibiotics is becoming recurrent and has demanded the need to generate new natural alternatives. Probiotics have gained importance as an option to use as growth promoters. This study aimed to evaluate Bacillus subtillis QST713 as a substitute for an antibiotic growth promoter ( BMD ). A total of 150 male broilers were assigned to three dietary treatments: 1) control diet ( CO ), 2) control diet + 500 g/t of BMD ( AGP ), and 3) control diet + 100 g/t of B. subtilis QST713 ( PB ), respectively. Each treatment was monitored for 5 wk for the productive variables: body weight, accumulated feed consumption, food conversion, and European efficiency factor. At the end of each week, fresh fecal samples were cultured and quantified for E. coli, Enterococcus spp., and Lactobacillus spp. At the end of the trial, blood samples were analyzed for hemogram and intestinal samples (anterior portion) for histomorphometry. The data were statistically analyzed with an analysis of variance and subjected to a least significant difference test (Tukey). The zootechnical yields were similar in the AGP and PB groups ( P ˃ 0.05); both superior to the control group. In the hematological profiles, no difference was observed between the experimental groups. E. coli and Enterococcus counts were significantly lower ( P ˂ 0.05), and Lactobacillus counts were significantly ( P ˂ 0.05) higher in the PB group, relative to CO and AGP groups. No differences ( P ˃ 0.05) were found in bacterial counts between the CO and AGP groups. The intestinal mucosa and villi in the PB group were significantly ( P ˂ 0.05) longer and with less deeper crypts than CO and AGP groups. We conclude that B. subtillis QST713, used at the suggested commercial dose (100 g/ton), is an effective growth-promoting alternative to BMD that modulates the microbiota and intestinal architecture, thus producing zootechnical yields consistent with BMD.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of the use of probiotic Bacillus subtilis (QST 713) as a growth promoter in broilers: an alternative to bacitracin methylene disalicylate

2021

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“…The absence of a common pattern in the effect of probiotics and their probiotic potential is directly connected to particular species, not to the genus or species of a microorganism. Studies with Bacillus subtilis, analyzing from performance to biochemistry parameters showed variable results [21,24,[62][63][64].…”

Section: Absence Of a Pattern In The Effect Of Probioticsmentioning

confidence: 99%

Probiotics as a Promising Additive in Broiler Feed: Advances and Limitations

Bahule¹,

Silva²

2021

Advances in Poultry Nutrition Research

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Feed additives have a strong influence on the production cost of broilers as growth-promoter’s to cover variations in profits due to fluctuation in feed costs. Antibiotics as additives were fundamental and indispensable, however, studies have shown their connection with the emergence of resistant strains of pathogens in animals and humans, therefore in recent years they have been less encouraged. Research is in progress concerning additives that can replace antibiotics as growth promotors and also as prophylactics. It was demonstrated that probiotics, which are living microorganisms and without residual effect’s have a potential to be used as microbials. However, they are not always guaranteed as growth promoters, as there are mechanisms of action regarding their interaction with the host that cannot yet be properly understood. The main advances in the use of probiotics in broilers in recent years, as well as the gaps, challenges, and future perspectives were carefully discussed and analyzed in this study. It was considered as a future premise, the possibility of reviewing the traditional methodologies used to test the hypotheses related to the effect of probiotics in broilers, which may also be extended to other animal species.

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“…Bilal, et al (2020), avaliando os efeitos de duas cepas de Bacillus (pumilus e subtilis) sobre o desempenho de crescimento, microbiota intestinal, imunidade e saúde intestinal, observaram que a suplementação com as duas cepas probiótica conferiu benefícios a saúde intestinal para os frangos de corte, promovendo a integridade e função intestinal juntamente com a ativação de TREG do sistema imunológico. Zhang, et al (2021), avaliando os efeitos do B. subtilis no desempenho de crescimento, morfologia intestinal e composição microbiana cecal de frangos de corte, observaram melhora no desempenho de crescimento das aves, composição da microbiota intestinal e manutenção da saúde intestinal das aves.…”

Section: Bacillus Subtilisunclassified

Uso de aditivos equilibradores de microbiota na alimentação de aves comerciais: Revisão

Silva

Rabello

Santos

et al. 2021

RSD

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Os antibióticos equilibradores de microbiota vêm sendo utilizados na alimentação animal desde a década de 50, por promoverem benefícios a saúde dos animais, entretanto o uso prolongado desses aditivos desencadeou a problemática da resistência bacteriana, o que levou os órgãos mundiais e nacional (WHO, UE, FDA e MAPA) a proibição de diversos aditivos. Contudo, aves em sistemas industriais são submetidas à ambientes adensados e desafiados, tornando impossível a isenção de compostos na dieta que modulem a microbiota intestinal e consequentemente favoreçam beneficamente a digestibilidade e absorção dos nutrientes da dieta. Neste aspecto a utilização de aditivos equilibradores de microbiota alternativos ao antibiótico como, prebiótico, probiótico e simbiótico tornam-se indispensáveis, por estes serem naturais, não causarem resistência bacteriana e promoverem mútuos benefícios à saúde animal. Com isso, está revisão tem por objetivo elucidar os benefícios dos aditivos equilibradores de microbiota na alimentação de aves poedeiras comerciais, com ênfase nos efeitos produzidos a partir da modulação da microbiota residente. A metodologia adotada foi o estudo descritivo, resultando em uma revisão bibliográfica embasada em artigos científicos mundiais.

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Dietary supplementation with Bacillus subtilis promotes growth performance of broilers by altering the dominant microbial community

Cited by 89 publications

References 68 publications

Effect of the use of probiotic Bacillus subtilis (QST 713) as a growth promoter in broilers: an alternative to bacitracin methylene disalicylate

Effect of the use of probiotic Bacillus subtilis (QST 713) as a growth promoter in broilers: an alternative to bacitracin methylene disalicylate

Probiotics as a Promising Additive in Broiler Feed: Advances and Limitations

Uso de aditivos equilibradores de microbiota na alimentação de aves comerciais: Revisão

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