Dietary supplementation with arachidonic acid in tilapia (Oreochromis mossambicus) reveals physiological effects not mediated by prostaglandins

Anholt, R. D. Van; Spanings, F.A.T.; Koven, William; Bonga, S.E. Wendelaar

doi:10.1016/j.ygcen.2004.09.007

Cited by 30 publications

(38 citation statements)

References 57 publications

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“…ARA has also been shown to affect stress resistance in several fish species. Dietary ARA levels of about 1% dry weight feed are necessary not only for optimum growth and survival of sea bream larvae (Bessonart et al 1999), but also for improved stress resistance after handling (Koven et al 2003, Van Anholt et al 2004. Dietary ARA levels close to those used by these authors did not affect the handling of stress resistance in Japanese flounder, whereas higher ones reduced larval stress resistance (Furuita et al 1998).…”

Section: Discussionmentioning

confidence: 67%

“…Moreover, vegetable oils in fish diets have been shown to regulate COX-derived eicosanoids directly (Ganga et al 2005). Dietary supplementation of other fatty acids such as ARA seems to be affecting plasma cortisol levels after stress (Van Anholt et al 2004), although the effect on cortisol release in vivo is dose dependent, since high levels of ARA in diet seem to be detrimental to chronic stress resistance in larval gilthead sea bream (Koven et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…In fish, several studies have suggested that ARA is involved in the release of cortisol, although the actual mechanisms have not been investigated (Gupta et al 1985, Bessonart et al 1999, Harel et al 2001, Koven et al 2003, Van Anholt et al 2004). In mammals, certain studies suggest that PG play an important role in mediating the corticosteroidogenic action of adrenocorticotropic hormone (ACTH) (Kocsis et al 1999), and thus the role of fatty acids in stress response seems to be mediated by the production of eicosanoids.…”

Section: Introductionmentioning

confidence: 99%

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Modulation of ACTH-induced cortisol release by polyunsaturated fatty acids in interrenal cells from gilthead seabream, Sparus aurata

Ganga¹,

Tort²,

Acerete³

et al. 2006

Journal of Endocrinology

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Highly unsaturated fatty acids are essential components of cellular membranes of vertebrates and can modulate physiological processes, including membrane transport, receptor function and enzymatic activities. In gilthead sea bream, dietary deficiencies of essential fatty acids of marine fish raise the basal cortisol levels and alter the pattern of cortisol release after stress. The aim of the present study was to clarify the effect of different essential fatty acids on adrenocorticotropic hormone (ACTH)-induced cortisol production and release in fish, through in vitro studies of sea bream interrenal cells maintained in superfusion and incubated with different types of fatty acids and eicosanoid production inhibitors. Results showed the first evidence of the effect of certain fatty acids on cortisol production by ACTH-stimulated interrenal cells in fish. Both arachidonic acid (ARA) and particularly eicosapentaenoic acid (EPA) promoted cortisol production in sea bream interrenal cells. Moreover, incubation with indometacin (INDO) reduced the increased cortisol production induced by EPA and ARA, suggesting mediation by their cyclooxygenase-derived products. Docosahexaenoic acid stimulated cortisol production to a lesser extent than that caused by EPA or ARA, but the inhibitory effect of INDO was not as marked as it was for the other fatty acids. In contrast, supplementation with dihomogammalinoleic acid reduced cortisol production, denoting the inhibitor effect of this fatty acid in cortisol secretion.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modulation of ACTH-induced cortisol release by polyunsaturated fatty acids in interrenal cells from gilthead seabream, Sparus aurata

Ganga¹,

Tort²,

Acerete³

et al. 2006

Journal of Endocrinology

View full text Add to dashboard Cite

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“…In the cyprinid golden shiner (Notemigonus crysoleucas) exchanging fish oil with soybean or cottonseed oil had no affect on pre or post stress (2h) cortisol levels (Lochmann et al 2004). In Mozambique tilapia feeding 20:4n-6 for 18 days did not affect plasma cortisol levels, nor did co-feeding with acetylsalicylic acid (Van Anholt et al 2004c). Furthermore, acetylsalicylic acid did not depress the cortisol response when the fish were subjected to acute stress, but rather increased it compared to the controls.…”

Section: Stress Responsementioning

confidence: 91%

Criteria for Safe Use of Plant Ingredients in Diets for Aquacultured Fish

Hemre

Amlund

Aursand

et al. 2018

EJNFS

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“…Significant ARA effects seem to occur when its dietary intake exceeds the requirement, leading to a higher abundance of the free intracellular form which can potentially directly or indirectly modulate various signalling pathways (Van Anholt et al 2004b). However, these effects also depend on the abundance of n-3 LC-PUFA, EPA and docosahexaenoic acid (DHA; 22:6n-3), which can inhibit ARA metabolism and alter the profile of regulatory eicosanoids (Calder 2009).…”

Section: Introductionmentioning

confidence: 99%

Cortisol response to air exposure in Solea senegalensis post-larvae is affected by dietary arachidonic acid-to-eicosapentaenoic acid ratio

Martins

Engrola

Morais

et al. 2011

Fish Physiol Biochem

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An experiment was conducted in order to evaluate the effects of feeding frozen Artemia diets differing in arachidonic acid-to-eicosapentaenoic acid ratios (ARA/EPA) on growth, survival and stress coping ability of Senegalese sole post-larvae (19-31 days after hatch). Two experimental diets presenting high ('High'; 3.0) or low ('Low'; 0.7) ARA/EPA ratios were tested under two rearing conditions: undisturbed (C) and stressed by a 2-min air exposure every two days (S). Growth, survival and basal cortisol levels were similar between groups indicating that independently of dietary ARA/EPA ratios, fish were able to cope with the repeated stress imposed. Also, cortisol levels at 3 h past air exposure were determined in all groups at the end of the experiment. Among fish fed the 'Low' diet, C groups seemed to present a quicker recovery from the acute stress (basal-like levels) than S groups. Repeated stress effects were not apparent in fish fed the 'High' diet and, relative to basal levels, twofold higher cortisol concentrations were detected at 3 h, in both C and S groups. This study suggests the importance of ARA in steroidogenesis regulation and the modulatory role of EPA in this process. Despite the tolerance to a wide range of dietary ARA/EPA as indicated by growth and survival results, acute stress coping response may be more efficient in Senegalese sole post-larvae fed low ARA/EPA ratios and, under these particular conditions, a faster recovery of cortisol to basal values could be indicative of rearing conditions (undisturbed vs. repeatedly stressed).

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Dietary supplementation with arachidonic acid in tilapia (Oreochromis mossambicus) reveals physiological effects not mediated by prostaglandins

Cited by 30 publications

References 57 publications

Modulation of ACTH-induced cortisol release by polyunsaturated fatty acids in interrenal cells from gilthead seabream, Sparus aurata

Modulation of ACTH-induced cortisol release by polyunsaturated fatty acids in interrenal cells from gilthead seabream, Sparus aurata

Criteria for Safe Use of Plant Ingredients in Diets for Aquacultured Fish

Cortisol response to air exposure in Solea senegalensis post-larvae is affected by dietary arachidonic acid-to-eicosapentaenoic acid ratio

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