Dietary supplementation with a fermented barley and soybean mixture attenuates UVB-induced skin aging and dehydration in hairless mouse skin

Kwon, Oh Wook; Venkatesan, Ramu; Ho, Moon; Ji, Eunhee; Cho, Dong Woon; Lee, Ki Won; Kim, Sun Yeou

doi:10.1007/s10068-015-0092-1

Cited by 7 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plant extracts have been used for cosmetics and skincare products since ancient times, as a complex mixture of natural compounds with different structures and functions. Reportedly, various plant extracts, such as fermented barley and soybean mixtures [ 22 ], horsetail ( Equisetum arvense L.) [ 23 ], Aloe vera [ 24 , 25 ], pine bark ( Pinus pinaster ), Citrus paradisi and Rosmarinus officinalis extracts, red-orange complex [ 26 ], and Polypodium leucotomos extract [ 27 ] are effective skincare agents in animal or clinical studies. Additionally, the fermented honeybush ( Cyclopia intermedia ) extract (HU-018) 400 mg or 800 mg, currently released as a health functional food, reduces skin wrinkles, improves skin elasticity, and enhances skin moisture [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

et al. 2020

View full text Add to dashboard Cite

Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1–R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.

show abstract

Section: Discussionmentioning

confidence: 99%

Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…( 13 ) BS is itself a yeast fermentation product with enhanced daidzein, genistein, and β-glucan content. ( 14 )…”

Section: Discussionmentioning

confidence: 99%

“…BS was prepared as described previously. ( 14 ) Primary human dermal fibroblasts (HDFs) were isolated from the outgrowth of foreskin obtained from 7–30-year-old healthy volunteers by JH Chung’s laboratory (Seoul National University Hospital, Korea) after approval from the Institutional Review Board at Seoul National University Hospital and Seoul National University. HaCaT cells were purchased from CLS Cell Lines Service GmbH (Eppelheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A fermented barley and soybean formula enhances skin hydration

Lee

Kim

Suk

et al. 2015

J. Clin. Biochem. Nutr.

Self Cite

View full text Add to dashboard Cite

Skin hydration is one of the primary aims of beauty and anti-aging treatments. Barley (Hordeum vulgare) and soybean (Glycine max) are major food crops, but can also be used as ingredients for the maintenance of skin health. We developed a natural product-based skin treatment using a barley and soybean formula (BS) incorporating yeast fermentation, and evaluated its skin hydration effects as a dietary supplement in a clinical study. Participants ingested a placebo- (n = 33) or BS- (3 g/day) containing drink (n = 32) for 8 weeks. A significant increase in hydration in the BS group as compared to the placebo group was observed on the faces of subjects after 4 and 8 weeks, and on the forearm after 4 weeks. Decreases in stratum corneum (SC) thickness were also observed on the face and forearm. BS enhanced hyaluronan (HA) and skin barrier function in vitro and reduced Hyal2 expression in human dermal fibroblasts (HDF). BS also recovered ultraviolet (UV) B-induced downregulation of HA in HaCaT cells. These results suggest that BS has promising potential for development as a health functional food to enhance skin health.

show abstract

“…In the study conducted in a hairless mouse model with a diet enriched with a mixture of fermented young barley and soybean, Kwon et al [ 17 ] observed a significant decrease in UV-induced wrinkle formation by reducing collagen degradation and UVB-induced epidermal thickening due to decreased MMP-1 expression. Additionally, supplementation has been shown to improve skin barrier function and reduce oxidative stress by increasing SOD activity [ 18 ]. Meng et al [ 17 ]] observed an inhibitory effect of methanolic barley grass extract on melanin biosynthesis in B16 melanoma cells.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Protective Effect of Young Barley (Hordeum vulgare L.) Dietary Supplements Extracts on UV-Treated Human Skin Fibroblasts in In Vitro Studies

et al. 2021

View full text Add to dashboard Cite

Young barley seems to be a promising material for use as nutricosmetic due to the presence of many biologically active compounds. The aim of this study was to evaluate the effect of Hordeum vulgare L. extracts on human skin fibroblasts exposed to ultraviolet radiation B (UVB) radiation. Analysis of the chemical composition showed a predominance of 9,12,15-octadecatrienoic acid. The quality assessment showed that young barley preparations have high total polyphenolic content (TPC) and favourable total antioxidant status (TAS). They also contain antioxidant elements such as zinc, copper, and selenium. Furthermore, the analyzed products were found to be safe in terms of toxic elements (lead, cadmium and mercury) and lack of cytotoxic effect of young barley extracts on cells. In vitro bioactivity assays showed that young barley extract increased the survival rate and accelerated the migration of fibroblasts in research models with UVB radiation. The application of both extracts caused an increase in DNA biosynthesis, and in the number of cells arrested in S phase. Moreover, an inhibitory effect of the tested extracts on the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) was observed. The results indicate that young barley extracts, due to protective as well as restorative effect, could potentially be used in the production of nutricosmetics and skin care products.

show abstract

Dietary supplementation with a fermented barley and soybean mixture attenuates UVB-induced skin aging and dehydration in hairless mouse skin

Cited by 7 publications

References 39 publications

Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

A fermented barley and soybean formula enhances skin hydration

Chemical Composition and Protective Effect of Young Barley (Hordeum vulgare L.) Dietary Supplements Extracts on UV-Treated Human Skin Fibroblasts in In Vitro Studies

Contact Info

Product

Resources

About