Dietary supplementation of neutral and acidic oligosaccharides enhances Th1‐dependent vaccination responses in mice

Vos, Anneke S. de; Haarman, Monique; Ginkel, Jan-Willem H van; Knol, Jan; Garssen, Johan; Stahl, Bernd; Boehm, G; M’Rabet, Laura

doi:10.1111/j.1399-3038.2007.00515.x

Cited by 99 publications

(88 citation statements)

References 32 publications

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“…The scGOS/lcFOS/pAOS diet contained 2 % (9:1:1, w/w) scGOS (Vivinal GOS, FrieslandCampina Domo, Zwolle, The Netherlands), lcFOS (Raftiline HP, Orafti, Wijchen, The Netherlands) and pAOS (Südzucker AG, Mannheim, Germany (9) ). scGOS/lcFOS spray-dried powder consisted of approximately 50 % scGOS and lcFOS (9:1), 19 % maltodextrin (Glucidex 2, Roquette, France), 16 % lactose, 14 % glucose and 1 % galactose (8) .…”

Section: Dietsmentioning

confidence: 99%

“…The combined use of neutral and acidic oligosaccharides was most effective in supporting the vaccination response in mice and has been shown to increase faecal Bifidobacteria and Lactobacilli (8,9) . The present study aims to address whether this particular scGOS/lcFOS/pAOS (9:1:1) mixture protects against the development of orally induced casein allergy in mice and to gain further insight into the underlying mechanism by which these oligosaccharides exert their effect.…”

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confidence: 99%

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A potential role for CD25⁺ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

et al. 2011

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Dietary non-digestible carbohydrates reduce the development of cows' milk allergy in mice. In the present study, the contribution of CD25 þ regulatory T-cells (T reg ) was investigated using in vivo T reg depletion and adoptive transfer studies. Mice were orally sensitised with casein and fed a diet containing 2 % short-chain galacto-, long-chain fructo-and acidic oligosaccharides (GFA) or a control diet. Donor splenocytes of mice sensitised with casein and fed the GFA or control diet were adoptively transferred to naive recipient mice, which were casein-or sham-sensitised and fed the control diet. In addition, in vivo or ex vivo CD25 þ T reg depletion was performed using anti-CD25 (PC61). The acute allergic skin response upon intradermal casein challenge and casein-specific Ig were determined. Furthermore, T-helper (T H ) 1 and T H 2 cell numbers were analysed in the mesenteric lymph nodes. The oligosaccharide diet strongly reduced the development of the acute allergic skin response, which was abrogated by the in vivo anti-CD25 treatment. The diet enhanced the percentage of T H 1 cells and tended to reduce the percentage of T H 2 cells in casein-sensitised mice. Recipient mice were protected against the development of an acute allergic skin response when transferred with splenocytes from casein-sensitised GFA-fed donor mice before sensitisation. Ex vivo depletion of CD25 þ T reg abrogated this transfer of tolerance. Splenocytes from sham-sensitised GFA-fed donor mice did not suppress the allergic response in recipient mice. In conclusion, CD25 þ T reg contribute to the suppression of the allergic effector response in casein-sensitised mice induced by dietary intervention with non-digestible carbohydrates.Key words: Cows' milk allergy: Prebiotics: Non-digestible carbohydrates: Oligosaccharides: Regulatory T-cells: CaseinOne of the first manifestations of atopic disease is the development of cows' milk allergy (CMA) in young infants. Casein, in particular aS1-casein, is the main allergenic protein in cows' milk (1,2) . Non-digestible carbohydrates such as short-chain galacto-oligosaccharides (scGOS) and long-chain fructooligosaccharides (lcFOS) mimic structural and functional properties of neutral oligosaccharides such as present in human breast milk and are added to clinical nutrition and infant milk formulas since they may have health and immunepromoting capacities (3,4) . Previously, in a mouse model of orally induced CMA this 9:1 scGOS/lcFOS mixture (Immunofortisw; Nutricia, Zoetermeer, The Netherlands) was found to reduce the allergic effector response to whey protein (5) .Furthermore, in a clinical study with infants at high risk of developing allergic disease, the same carbohydrate mixture reduced the incidence of atopic dermatitis significantly (6) .Acidic oligosaccharides derived from pectin (pAOS) are non-digestible carbohydrates that mimic properties of human milk acidic oligosaccharides (7) . The combined use of neutral and acidic oligosaccharides was most effective in supporting the vaccinati...

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Section: Dietsmentioning

confidence: 99%

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confidence: 99%

A potential role for CD25⁺ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

et al. 2011

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“…The response to vaccination of mice fed the scGOS/lcFOS diet was significant enhanced, as well as the fecal Bifidobacteria and Lactobacilli proportions. pAOS enhanced the murine vaccination response and the combination (scGOS/lcFOS/pAOS) was even more effective (Vos, Haarman et al 2007). To stimulate the entire microbiota a great variation in the oligosaccharide structures will exert this effect, as human milk oligosaccharides comprise of many different oligosaccharides.…”

Section: Nondigestible Oligosaccharidesmentioning

confidence: 99%

Development of the Immune System - Early Nutrition and Consequences for Later Life

Kerperien¹,

Schouten²,

Boehm³

et al. 2012

Recent Advances in Immunology to Target Cancer, Inflammation and Infections

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“…Moreover, the oligosaccharides and modified polymers from the degradation of DFs by microbiota may directly interact with the receptors in the immune cell and consequently stimulate the immune response. It has been reported that pectin derived acidic oligosaccharides (AOS), galacto-oligosaccharides (GOS) and fructooligosaccharides (FOS) can modulate the immune system in mice (Vos et al, 2007).…”

Section: Interactions Between Dietary Fiber and Microbiotamentioning

confidence: 99%

“…Next to the pectic polymers, the specific oligomers produced by microbial degradation of pectins could also potentially stimulate immune response by direct interacting with receptors on immune cells (Vos et al, 2007). The formation, identification and the time of existence in the colon before being further fermented should be studied in detail.…”

Section: Future Perspectivesmentioning

confidence: 99%

Influence of pectin supplementation on feed fermentation characteristics in rats and pigs

Tian¹

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at 11 a.m. in the Aula. Lingmin TianInfluence of pectin supplementation on feed fermentation characteristics in rats and pigs 152 pages PhD thesis, Wageningen University, Wageningen, NL (2016) With references, with summary in English ISBN: 978-94-6257-728-2 AbstractThe physiological effects of dietary fiber (DFs) depend on several factors including structural features of the DFs, composition and activity of colonic microbiota, and products formed during fermentation. In this thesis, the influence of pectin supplementation to feed fermentation characteristics in rats and pigs was studied. The non-starch polysaccharides (NSP) present in the selected feed ingredient oats were characterized. Distinct populations of arabinoxylans (AXs) were observed in oats, compared to those reported for other cereals like wheat and barley. The fate of cereal AXs and soybean pectin during fermentation and the consequent effects on appetite regulation and fat accumulation were studied in rats as a model. Oat AXs were fermented less rapidly than wheat AXs in the caecum of rats. Soy pectin was fermented more early and efficiently than cereal AXs. A significant inverse correlation between rat retroperitoneal fat-pad weight and concentration and relative SCFA proportion of butyrate was observed. In a following in vivo rat experiment, commercial soy pectin together with three other soluble pectins originating from citrus and sugar beet and differing in their methyl esterification were individually supplemented to the diets. Their effects on the utilization of the different DFs present in the feed and the consequent effect on the microbial community in the colon of rats was studied. All pectins were fermented rapidly and consequently shifted fermentation of other consumed DFs (e.g. cereal AXs) to more distal part of colon, although low-methyl esterified pectin was more efficiently fermented by the microbiota than high-methyl esterified pectin. Results suggested that pectins can confer beneficial health effects through modulation of the gut microbiota. In a last in vivo experiment, citrus pectins together with a hydrothermal treated soybean meal were supplemented to pig diets to study their effect on the digestion and fermentation of carbohydrates in both the small and large intestine. Pectins, and more particularly lowmethyl esterified pectin, decreased the ileal digestibility of digestible starch resulting in more starch to be fermentated in the proximal colon of pigs. Consequently, also the fermentation patterns of DFs and the microbiota composition was affected. All pectins tested shaped the colonic microbiota from a Lactobacillus-dominated microbiota to a Prevotella-dominated community, with potential health-promoting effects.

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Dietary supplementation of neutral and acidic oligosaccharides enhances Th1‐dependent vaccination responses in mice

Cited by 99 publications

References 32 publications

A potential role for CD25⁺ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

A potential role for CD25⁺ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

Development of the Immune System - Early Nutrition and Consequences for Later Life

Influence of pectin supplementation on feed fermentation characteristics in rats and pigs

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Dietary supplementation of neutral and acidic oligosaccharides enhances Th1‐dependent vaccination responses in mice

Cited by 99 publications

References 32 publications

A potential role for CD25+ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

A potential role for CD25+ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

Development of the Immune System - Early Nutrition and Consequences for Later Life

Influence of pectin supplementation on feed fermentation characteristics in rats and pigs

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A potential role for CD25⁺ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

A potential role for CD25⁺ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates