Dietary supplementation of bile acid attenuate adverse effects of high-fat diet on growth performance, antioxidant ability, lipid accumulation and intestinal health in juvenile largemouth bass (Micropterus salmoides)

Yin, Peng; Xie, Shiwei; Zhuang, Zhenxiao; He, Xuanshu; Tang, Xipei; Liu, Tian; Liu, Yongjian; Niu, Jin

doi:10.1016/j.aquaculture.2020.735864

Cited by 105 publications

(81 citation statements)

References 76 publications

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“…When largemouth bass fed HFD, higher VSI, HSI and IPF were observed, higher lipid contents in muscle, liver and whole body also were observed. These results indicated HFD induced more lipid accumulation in several tissues (viscera and muscle) of largemouth bass, similar results were found in our previous research [ 12 ] and several studies in largemouth bass [ 31 ], giant croaker [ 28 ] and cobia [ 10 ]. The supplementation of astaxanthin in HFD decreased the HSI and IPF of largemouth bass, while having no effects on lipid contents in the whole body, muscle and liver.…”

Section: Discussionsupporting

confidence: 91%

“…Besides the anti-oxidative ability, the immune response of fish also was affected by HFD and astaxanthin. IL 15 and TGF-β are two critical inflammatory cytokines [ 12 ], HFD increased the mRNA expression of IL15 and decreased the mRNA expression of TGF-β in this study, which indicated hepatic inflammation of largemouth bass may be induced by HFD. Dietary supplementation of astaxanthin reduced the expression of IL15 , but could not enhance the expression of anti-inflammatory cytokines TGF-β .…”

Section: Discussionmentioning

confidence: 51%

“…The synthetic astaxanthin (Carophyll Pink, 10%) was obtained from DSM (Heerlen, Netherlands). The lipid levels were adopted according to our previous study [ 12 ]. The ingredients were smashed and well mixed, the 2.5 mm diameter pellets were extruded using a twin-screw cooking extruder (HQ, Zhaoqing, China).…”

Section: Methodsmentioning

confidence: 99%

“…Oil red O staining was performed to determine the number of neutral lipids deposited in the liver, the method was described as Yin et al (2021) [ 12 ]. Liver samples were firstly fixed with 4% paraformaldehyde and then frozen with liquid nitrogen.…”

Section: Methodsmentioning

confidence: 99%

“…In many studies, long-term intake of HFD induced reactive oxygen species (ROS) production, oxidative stress and inflammation to fish, and finally negatively affected the growth performance and health of fish [ 8 , 9 , 10 ]. Previous research indicated that lipid accumulation of largemouth bass increased with the increasing dietary lipid levels [ 11 ], and several studies revealed that high dietary lipid (18–20%) impaired the growth and health of largemouth bass [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Supplementation of Astaxanthin Improved the Growth Performance, Antioxidant Ability and Immune Response of Juvenile Largemouth Bass (Micropterus salmoides) Fed High-Fat Diet

et al. 2020

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High-fat diet (HFD) usually induces oxidative stress and astaxanthin is regarded as an excellent anti-oxidant. An 8-week feeding trial was conducted to investigate the effects of dietary astaxanthin supplementation on growth performance, lipid metabolism, antioxidant ability, and immune response of juvenile largemouth bass (Micropterus salmoides) fed HFD. Four diets were formulated: the control diet (10.87% lipid, C), high-fat diet (18.08% lipid, HF), and HF diet supplemented with 75 and 150 mg kg−1 astaxanthin (HFA1 and HFA2, respectively). Dietary supplementation of astaxanthin improved the growth of fish fed HFD, also decreased hepatosomatic index and intraperitoneal fat ratio of fish fed HFD, while having no effect on body fat. Malondialdehyde content and superoxide dismutase activity were increased in fish fed HFD, astaxanthin supplementation in HFD decreased the oxidative stress of fish. The supplementation of astaxanthin in HFD also reduced the mRNA levels of Caspase 3, Caspase 9, BAD, and IL15. These results suggested that dietary astaxanthin supplementation in HFD improved the growth performance, antioxidant ability and immune response of largemouth bass.

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