Dietary supplement use and colorectal cancer risk: A systematic review and meta‐analyses of prospective cohort studies

Heine-Bröring, Renate C.; Winkels, Renate M.; Renkema, J.M.S.; Kragt, Lea; Orten-Luiten, A.C.B. van; Tigchelaar, Ettje F.; Chan, Doris S. M.; Norat, Teresa; Kampman, Ellen

doi:10.1002/ijc.29277

Cited by 100 publications

(86 citation statements)

References 63 publications

(146 reference statements)

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“…Vitamin C plays a key role in the production of collagen and its deficit upsets the integrity of intracellular matrix and promotes tumor proliferation. Heine-Broring et al (25) suggested an inverse correlation between risk of CRC and deficiency of vitamins A, E, and C, similar findings were observed in this study. On the other hand, recently, no association was found between supplementation of these dietary vitamins and risk of CRC (26).…”

Section: Discussionsupporting

confidence: 91%

Implications of Isoprostanes and Matrix Metalloproteinase-7 Having Potential Role in the Development of Colorectal Cancer in Males

Rasool

Malik

Ghuman³

et al. 2018

Front. Oncol.

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BackgroundColorectal cancer (CRC) is the third most common type of cancer and leading cause of death worldwide. Major risk factors involved in the development of CRC are increased dietary sources, genetics, and increasing age. Purpose of the study was to find the role of different variables in the progression of CRC.Methodology50 blood samples from CRC patients and 20 samples from control were collected. Serum was separated from the blood by centrifugation. This serum was assessed for several antioxidants like superoxide dismutase (SOD), glutathione, glutathione peroxidase, glutathione reductase, catalase, vitamin A, C, and E, and pro-oxidants such as malondialdehyde, advanced oxidation protein products (AOPPs), and AGEs according to their respective protocols. Matrix metalloproteinase-7 (MMP-7) and isoprostanes were assessed by ELISA kits.ResultsLower levels of GSH (4.86 ± 0.78 vs 9.65 ± 1.13 μg/dl), SOD (0.08 ± 0.012 vs 0.46 ± 0.017 μg/dl), CAT (2.45 ± 0.03 vs 4.22 ± 0.19 μmol/mol of protein), and GRx (5.16 ± 0.06 vs 7.23 ± 0.36 μmol/ml) in the diseased group were recorded as compared with control. Higher levels of GPx (6.64 ± 0.19 mmol/dl) were observed in the subjects in comparison with control group (1.58 ± 0.30 mmol/dl). Highly significant decreased levels of vitamin A (0.81 ± 0.07 vs 2.37 ± 0.15 mg/ml), vitamin E (15.42 ± 1.26 vs 25.96 ± 2.19 mg/ml), and vitamin C (47.67 ± 7.69 vs 80.37 ± 10.21 mg/ml) were observed in the patients in contrast to control group. The reversal of antioxidants in later stages of CRC may be due to compensatory mechanisms in cancerous cells. The levels of MDA (nmol/ml) were also assessed, which shows significantly increased level in CRC patients as compared with control groups (3.67 ± 0.19 vs 1.31 ± 0.27). The levels of protein oxidation products [AGEs (2.74 ± 0.16 vs 0.84 ± 0.05 IU) and AOPPs (1.32 ± 0.02 vs 0.82 ± 0.07 ng/ml)] were significantly increased in subjects as compared with control. The levels of MMP-7 (64.75 ± 3.03 vs 50.61 ± 4.09 ng/ml) and isoprostanes (0.71 ± 0.03 vs 0.16 ± 0.02 ng/ml) were also analyzed. This shows that the levels of isoprostanes increased due to high lipid peroxidation mediate higher levels of MMP-7, which promotes development of CRC.ConclusionFollowing study suggested that elevated oxidative and inflammatory status along with lipid peroxidation and matrix metalloproteinases are the chief contributors in the progression of CRC.

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Section: Discussionsupporting

confidence: 91%

Implications of Isoprostanes and Matrix Metalloproteinase-7 Having Potential Role in the Development of Colorectal Cancer in Males

Rasool

Malik

Ghuman³

et al. 2018

Front. Oncol.

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“…Both a high intake of red meat and a low intake of calcium were associated with polyp growth [32]. Food supplementation such as multivitamin intake and calcium supplementation also seems to be beneficial in this context [33]. Alcohol consumption was associated with an increased risk for advanced adenomas [34].…”

Section: Factors Influencing the Adrmentioning

confidence: 99%

Endoscopic Improvement of the Adenoma Detection Rate during Colonoscopy - Where Do We Stand in 2015?

Floer

Meister²

2016

Digestion

238

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Background: The presence of colorectal adenomas is considered a major risk factor for colorectal cancer development. The implementation of screening colonoscopy programs in the Western world has led to a substantial reduction of colorectal cancer death. Many efforts have been made to reduce the adenoma miss rates by the application of new endoscopic devices and techniques for better adenoma visualization. Summary: This special review gives the readership an overview of current endoscopic innovations that can aid in the increase of the adenoma detection rate (ADR) during colonoscopy. These innovations include the use of devices like EndoCuff® and EndoRings® as well as new technical equipment like third-eye endoscope® and full-spectrum endoscopy (FUSE®). Key Message: Technical improvements and newly developed accessories are able to improve the ADR. However, additional costs and a willingness to invest into potentially expensive equipment might be necessary. Investigator-dependent skills remain the backbone in the ADR detection.

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“…As recognized by the general public, Ca supplementation, apart from decreasing the risk of osteoporosis, may also have an impact on cancer prevention and play a role in the decrease in cardiovascular disorders [6,12]. These assumptions are, however, only partially supported and require further studies [11,13,14]. Moreover, some studies support the view that Ca supplementation may even increase the risk of adverse cardiovascular events and have a deteriorating effect on lipid levels [15,16].…”

Section: Discussionmentioning

confidence: 99%

The bioavailability of calcium in the form of pyruvate, carbonate, citrate–malate in healthy postmenopausal women

Rzymski

Pischel

Conrad³

et al. 2015

Eur Food Res Technol

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administration with the greatest values observed for the former. All the studied formulas decreased the intact parathyroid hormone level in serum although the greatest change was observed for CaPyr and CaCarb. The administration of CaPyr induced gastrointestinal side effects, dyspepsia and diarrhea in 16.6 % of the studied individuals. No serious adverse events were noted. CaPyr demonstrates both a promising source of Ca and a potential for use in osteoporosis prevention. Further investigations should focus on the long-term dietary effects of CaPyr supplementation to assess its safety and potential beneficial effect on human Ca turnover.

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Dietary supplement use and colorectal cancer risk: A systematic review and meta‐analyses of prospective cohort studies

Cited by 100 publications

References 63 publications

Implications of Isoprostanes and Matrix Metalloproteinase-7 Having Potential Role in the Development of Colorectal Cancer in Males

Implications of Isoprostanes and Matrix Metalloproteinase-7 Having Potential Role in the Development of Colorectal Cancer in Males

Endoscopic Improvement of the Adenoma Detection Rate during Colonoscopy - Where Do We Stand in 2015?

The bioavailability of calcium in the form of pyruvate, carbonate, citrate–malate in healthy postmenopausal women

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