Dietary Sodium Intake and Migraine: Is Salt the Answer?

Blitshteyn, Svetlana

doi:10.1111/head.12869

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…The primary preferred fuel for the brain is ketones, as demonstrated earlier. Diets low in carbohydrate, such as the ketogenic, low carb-high fat (LCHF), and carnivore diets ( 136 , 137 ), as well as consumption of appropriately higher levels of sodium ( 130 , 138 ) are beneficial. Studies show that fatty acid utilization for fuel in the brain is key for repairing neurodegenerative disorders ( 139 ).…”

Section: The Cause Of Migrainementioning

confidence: 99%

Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective

Stanton

2024

Front. Nutr.

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This article presents a hypothesis explaining the cause of migraines, suggesting that electrolyte imbalance, specifically a lack of sufficient sodium in the extracellular space of sensory neurons, leads to failed action potentials. The author argues that migraines are triggered when sodium channels fail to initiate action potentials, preventing communication between neurons. The article discusses the evolutionary perspective of the migraine brain, stating that migraineurs have a hypersensitive brain with more sensory neuronal connections, making them more reactive to environmental stimuli and in need of more minerals for the increased sensory neuronal communication. Since glucose is often used to reduce serum hypernatremia, it follows that a high carbohydrate diet reduces sodium availability for use in the brain, causing an electrolyte imbalance. Low carbohydrate diets, such as ketogenic, low carb-high fat (LCHF), and carnivore (all animal products), can be beneficial for migraineurs by reducing/eliminating carbohydrate intake, thereby increasing sodium availability. In support, many research papers and some anecdotal evidences are referred to. The article concludes by proposing lifestyle modifications, such as dietary changes and sodium intake management. These will provide migraineurs with a long-term healthy metabolic foundation helping them to maintain strong nutritional adherence and with that aiding continued proper neuronal functioning and migraine free life.

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Section: The Cause Of Migrainementioning

confidence: 99%

Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective

Stanton

2024

Front. Nutr.

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“…The mechanism linking these non-pharmacologic interventions and improved migraine control is not well understood. It has been hypothesized that increased intravascular volume (through hydration and dietary sodium) 70,71 and augmented cardiac output (through high-intensity cardiovascular exercise) both increase cerebral perfusion and modulate neuronal excitability; this in turn may be beneficial in patients with migraine given the literature suggesting a role for cortical hyperexcitability in migraine pathophysiology. 72,73 Pharmacologic Fludrocortisone is a synthetic mineralocorticoid that is functionally similar to aldosterone and structurally related to cortisol.…”

Section: Non-pharmacologicmentioning

confidence: 99%

Postural orthostatic tachycardia syndrome and migraine: A narrative review

Mueller

Robinson‐Papp

2022

Headache

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Objective In this narrative review, we summarize experimental and clinical evidence demonstrating mechanistic connections between POTS and migraine. Background Migraine is the most common comorbidity in patients with POTS, a heterogenous disorder of the autonomic nervous system characterized by orthostatic intolerance and positional tachycardia. POTS is a debilitating illness with few effective treatments. We aim for this narrative review to increase awareness of the mechanistic connections between POTS and migraine providing foundational information that optimizes clinical care and advances the development of pathophysiologic‐based treatments. Methods We used the PubMed and Medline databases in November 2021 to perform a literature review and searched for the following keywords: “postural orthostatic tachycardia syndrome,” “POTS,” “autonomic nervous system,” AND “migraine,” “headache.” Results The high prevalence of migraine in patients with POTS may be explained by common pathologic mechanisms. There is evidence that dysregulation of the sympathetic nervous system, alterations in central and peripheral hemodynamics, and central sensitization increase vulnerability to both POTS and migraine. Non‐pharmacologic and pharmacologic treatments that target these shared mechanisms may provide significant benefit for the patient with POTS and migraine. Conclusions Identification of common affected pathways may provide important insight that advances our understanding and treatment of both migraine and POTS.

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Non-pharmacological Management (Hydration, Diet and Compression)

Eftekhari

Bruce

2020

Postural Tachycardia Syndrome

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Dietary Sodium Intake and Migraine: Is Salt the Answer?

Cited by 5 publications

References 13 publications

Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective

Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective

Postural orthostatic tachycardia syndrome and migraine: A narrative review

Non-pharmacological Management (Hydration, Diet and Compression)

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