Dietary selenium's protective effects against methylmercury toxicity

Ralston, Nicholas V.C.; Raymond, Laura J.

doi:10.1016/j.tox.2010.06.004

Cited by 416 publications

(257 citation statements)

References 99 publications

(117 reference statements)

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“…Among fungi M. procera is relatively rich in Se. As reviewed recently, Se content of the caps of M. procera usually varies around 5 mg kg -1 dm [61]. In a recent study, the average Se content of M. procera (n=11) collected from Spain were 16±9 mg kg -1 dm for the hymenophores and 5.5±2.3 mg kg -1 dm for the rest of the fruiting body (including inedible stipes) [39].…”

Section: Mercurymentioning

confidence: 90%

Mineral Constituents of Edible Field Parasol (Macrolepiota procera) Mushrooms and the Underlying Substrate from Upland Regions of Poland: Bioconcentration Potential, Intake Benefits, and Toxicological Risk

Kojta¹,

Gucia²,

Krasińska³

et al. 2016

Pol. J. Environ. Stud.

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Fungi play a key role in the transfer of metals from the lithosphere into the biosphere. Within the biodiverse world, mushrooms are the important groups that constitute edible and medicinal mushrooms. Most of the estimated 2,000 species of edible wild mushrooms that grow worldwide are poorly characterized with respect to their composition and multi-mineral constituents as well as their bio-accessibility, while such information is completely absent for numerous species. In the studies of metallic elements and metalloids in mushrooms, the pertinent question is the unraveling of the qualitative and quantitative interrelationships between the elements/ Pol. J. Environ. Stud. Vol. 25, No. 6 (2016), 2445-2460 Original Research AbstractThis paper presents analytical and scientific monitoring data on the bioconcentration potential of trace elements and mineral compounds in Macrolepiota procera collected from background areas in upland regions of central Poland. The contents of Ag, Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Pb, Rb, Sr, and Zn in caps and stipes (99 specimens) and underlying soil substrates were examined by ICP-OES and Hg by CV-AAS after wet digestion. The results showed that M. procera is a rich source of especially Ca, Cu, Fe, K, Mg, Mn, Na, and Zn. The contents of Pb, Hg, Ag, and Cd in the caps were 1.7±0.6 to 5.9±1.7, 1.8±0.8 to 5.3±0.8, 1.2±0.7 to 16±7, and 0.56±0.13 to 4.9±5.4 mg kg -1 dry matter, respectively. Probable dietary intake assessment showed that occasional consumption (once a week) of Macrolepiota procera caps could be safe, while consumption more than once a week could provide doses of toxic metals that exceed the provisionally allowed daily intake limits for humans.

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Section: Mercurymentioning

confidence: 90%

Mineral Constituents of Edible Field Parasol (Macrolepiota procera) Mushrooms and the Underlying Substrate from Upland Regions of Poland: Bioconcentration Potential, Intake Benefits, and Toxicological Risk

Kojta¹,

Gucia²,

Krasińska³

et al. 2016

Pol. J. Environ. Stud.

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“…These differences may result from species identity and the different diets of these mammals. Foxes commonly eat rodents, birds and fish, which contain large amounts of Se [9,14], whereas dogs from northwest Poland ate mainly leftovers of the owners' meals. The normal action of the heart depends on the concentration of selenium, and low levels of this element may cause heart dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…These enzymes have beneficial effects on the growth and proliferation of cells and antibody production, and also increase the activity of immune cells and detoxify the body of heavy metals [1,3,5,6,7]. Interactions between Se and cadmium (Cd), mercury (Hg) and lead neutralize the toxic effects of heavy metals [8,9].…”

Section: Introductionmentioning

confidence: 99%

Stężenie selenu w narządach i tkankach psa domowego (Canis lupus familiaris) z terenu północno-zachodniej Polski

Kot

Piekara

Kosik-Bogacka

et al. 2017

Pomeranian J Life Sci

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Introduction: Selenium (Se) is a component of oxidoreductases and cytochromes. It also influences the growth and proliferation of cells, and it is essential for the proper functioning of the immune system. The aim of the study was to determine selenium concentration in the liver, kidneys, lungs, heart and muscles of dog (Canis lupus familiaris) from northwestern Poland. Materials and methods: Samples of organs and tissues were collected from 15 dogs at the age of 1 month to 17 years. The dogs were fed a diet similar to humans, with a small amount of commercial feed. Selenium concentration in the organs was determined spectrofluorometrically. Results:The highest Se concentration was found in the kidneys (0.57 ±0.42 mg/kg of wet weight -ww) and the lowest in muscles (0.11 ±0.09 mg/kg, ww). Mean selenium concentrations in the examined organs followed the order: kidneys>liver>lungs >heart>muscles. Conclusions: Our study shows that the Se concentration in the studied materials was below optimal level in 75% of the analysed dogs. This means that 75% of dogs had a deficiency of this element. The results obtained in this research suggest that the animal diet, which was very similar to the human diet, was not sufficient to ensure an optimum Selenium level in the bodies of these animals. Keywords: selenium; dog; Poland. ABSTRAKT Wstęp: Selen (Se) jest składnikiem enzymów oksydoredukcyjnych i cytochromów. Wpływa również na wzrost i proliferację komórek oraz jest niezbędny do prawidłowego funkcjonowania układu immunologicznego. Celem badań było oznaczenie stężenia selenu w wątrobie, nerkach, płucach, sercu i tkance mięśniowej psa domowego (Canis lupus familiaris) z terenu północno-zachodniej Polski. Materiały i metody: Próbki narządów i tkanek pobrano od 15 psów w wieku od 1 miesiąca do 17 lat. Dieta zwierząt była podobna do diety człowieka, z niewielką ilością komercyjnej karmy. Stę-żenia selenu były oznaczane metodą spektrofluorymetryczną.Wyniki: Największe średnie stężenie Se u badanych psów stwierdzono w nerkach (0,57 ±0,42 mg/kg mokrej masy -m.m.), a najmniejsze w mięśniach (0,11 ±0,09 mg/kg m.m.). Średnie stęże-nie Se w badanych narządach i tkankach psów można ułożyć w następujący szereg: nerki>wątroba>płuca>serce>mięśnie. Wnioski: U 75% badanych psów wartości stężenia Se w badanych materiałach znajdowały się poniżej optymalnego poziomu, co świadczy o niedoborze Se. Wyniki są dowodem na to, że dieta psów bardzo podobna do diety ludzkiej nie jest wystarczająca dla optymalnego poziomu Se w organizmach zwierząt.

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“…The lower regression strength observed in THg-d 15 N std regressions against MeHg-d 15 N std would appear to be the product of a number of factors. These include (1) selective uptake of MeHg over inorganic Hg within the guts of predators as a result of cellular partitioning (Mason et al 1995), (2) bioaccumulation of inorganic species of Hg through dissolved or sedimentary phases (Borgå et al 2012;Coelho et al 2013), (3) the fraction of THg as MeHg in invertebrates varying widely as a result of feeding strategies and speciesspecific habits (Evers et al 2008;Coelho et al 2013), and (4) the insolubility of inorganic Hg, such as mercury selenide (HgSe), contained within prey, making it unavailable for dietary absorption (Ralston and Raymond 2010). All of these conditions would reduce regression strength.…”

Section: Discussionmentioning

confidence: 99%

Application of stable isotope mixing models for defining trophic biomagnification pathways of mercury and selenium

Jones

Swadling

Butler

et al. 2014

Limnology & Oceanography

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Trophic models based on nitrogen stable isotope ratios (d 15 N) have been shown to predict changes in mercury (Hg) concentrations in fish; however, they are usually applied at the ecosystem scale and are rarely directed at known trophic pathways. We discuss a novel approach in which we combined gut contents analysis and stable isotope analyses (d 15 N and d 13 C) into a Bayesian isotopic mixing model to provide a quantitative estimate of Hg and selenium (Se) biomagnification in an estuarine food web. Estimates of the relationship between total mercury (THg) and methylmercury (MeHg) were significantly improved in mixing model-adjusted food webs over models that included all known prey sources. Spatial differences in dietary composition and MeHg bioavailability offer strong evidence that local food webs can have a significant effect on the biomagnification of Hg within benthic fish species. While no evidence of Se biomagnification was found, lower Se : Hg ratios at higher trophic levels could be attributed to increasing trophic Hg concentration. Furthermore, stable isotope analysis suggested Hg and Se biotransfer from benthic sources to fish. Overall, the findings highlight that isotope mixing models can be a significant aid in assessments of contaminant biomagnification, particularly when it is important to define food pathways to top predators.

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Dietary selenium's protective effects against methylmercury toxicity

Cited by 416 publications

References 99 publications

Mineral Constituents of Edible Field Parasol (Macrolepiota procera) Mushrooms and the Underlying Substrate from Upland Regions of Poland: Bioconcentration Potential, Intake Benefits, and Toxicological Risk

Mineral Constituents of Edible Field Parasol (Macrolepiota procera) Mushrooms and the Underlying Substrate from Upland Regions of Poland: Bioconcentration Potential, Intake Benefits, and Toxicological Risk

Stężenie selenu w narządach i tkankach psa domowego (Canis lupus familiaris) z terenu północno-zachodniej Polski

Application of stable isotope mixing models for defining trophic biomagnification pathways of mercury and selenium

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