Dietary selenium intake is negatively associated with serum sialic acid and metabolic syndrome features in healthy young adults

Zulet, M. Ángeles; Puchau, Blanca; Hermsdorff, Helen Hermana Miranda; Navarro, Cristina; Martínéz, J. Alfredo

doi:10.1016/j.nutres.2008.11.003

Cited by 43 publications

(33 citation statements)

References 41 publications

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“…Moreover, a decrease in nail Se concentrations in subjects with inflammatory diseases compared with healthy subjects had been previously reported [20][21][22][23]38]. Furthermore, several studies have evidenced the interaction of dietary antioxidant trace elements such as Se with inflammation-related markers including declared intake [39,40] and nail concentrations [41,42], highlighting the relationship between inflammation and concentrations of antioxidants. However, the intimate mechanisms have not been fully elucidated.…”

Section: Discussionmentioning

confidence: 71%

Nail Antioxidant Trace Elements Are Inversely Associated with Inflammatory Markers in Healthy Young Adults

Puchau

Zulet

Hermsdorff

et al. 2009

Biol Trace Elem Res

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Antioxidant intake may be linked to a reduction of the chronic low-grade inflammatory state related to obesity and several accompanying disorders such as insulin resistance, cardiovascular diseases, and metabolic syndrome. So, the aim of this study was to evaluate the potential associations between nail trace elements and several indicators in healthy young adults, emphasizing on the putative effect of antioxidant trace element intake on inflammation-related marker concentrations. This study enrolled 149 healthy young adults, whose anthropometrical and blood pressure values as well as lifestyle features were analyzed. Fasting blood samples were collected for the biochemical and inflammation-related measurements (C-reactive protein, tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-18, and homocysteine). Nail samples were collected for the analysis of selenium, zinc, and copper concentrations. Our results showed that nail selenium was negatively associated with IL-18; nail zinc concentrations were inversely related to circulating IL-6, IL-18, and TNF-alpha, whereas nail copper (Cu) and Cu/selenium values were negatively correlated with homocysteine levels and the Cu/zinc ratio was unaffected. In conclusion, nail content on some trace elements related to antioxidant defense mechanisms seems to be associated with several inflammation-related markers linked to chronic diseases in apparently healthy young adults, which is of interest to understand the role of antioxidant intake.

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Section: Discussionmentioning

confidence: 71%

Nail Antioxidant Trace Elements Are Inversely Associated with Inflammatory Markers in Healthy Young Adults

Puchau

Zulet

Hermsdorff

et al. 2009

Biol Trace Elem Res

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“…Thus, we performed similar calculations using an FFQ that had been previously validated for estimating food and nutrient intake [22][23][24][25], including settings related to inflammation and oxidative stress issues [19,35,36,44,45]. Moreover, according to our results, the TAC intake was related to such food groups as vegetables, fruits, and legumes [43], which are among the most important contributors of dietary antioxidant nutrients or components [16] and dietary TAC values [27].…”

Section: Discussionmentioning

confidence: 72%

“…Thus, nail and dietary selenium have been involved in oxidative stress-related diseases in healthy adults [19,35,36], which highlights the putative relationships between disease development and antioxidant intake. In this context, many studies report the ability of the dietary intake to modulate antioxidant status after the acute consumption of antioxidantrich foods [37][38][39][40].…”

Section: Discussionmentioning

confidence: 97%

Dietary Total Antioxidant Capacity: A Novel Indicator of Diet Quality in Healthy Young Adults

Puchau

Zulet

Echávarri

et al. 2009

Journal of the American College of Nutrition

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113

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“…Many studies have associated adequate/high levels of selenium in the organism with protective effects against different chronic diseases [18][19][20]. It has also been stated that selenium supplementation exerts beneficial effects on antioxidant activity by increasing glutathione peroxidase activity [14,[21][22][23][24][25][26][27][28] or by interacting with inflammatory biomarkers [12,[29][30][31], although adverse effects of an elevated Selenium consumption cannot be ruled out [14].…”

mentioning

confidence: 99%

Frequent Consumption of Selenium-Enriched Chicken Meat by Adults Causes Weight Loss and Maintains Their Antioxidant Status

Navas-Carretero

Cuervo

Abete

et al. 2010

Biol Trace Elem Res

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To assess the effects of a moderately high-protein intake on the body composition, biochemical, and antioxidant status parameters in young adults depending on either selenium- (Se) or non-enriched chicken consumption. The volunteers (n = 24) that completed the 10-week nutritional intervention were distributed in two parallel groups and randomly assigned to follow an isocaloric diet with moderately high content in protein (30% energy), either with the consumption of four 200 g portions/week of Se- or non-enriched chicken breasts. Blood samples were taken at the beginning and at the end of the study and body composition was monitored during the trial. There was a significant reduction in weight, accompanying a decrease on fat mass in both groups, while fat-free mass remained unchanged during the 10 weeks of intervention, without differences between both dietary groups. Selenium blood levels and plasma glutathione peroxidase activity, as well as lipid, glucose, and selected inflammation biomarkers remained stable during the intervention period in both dietary groups. Frequent chicken consumption, within a controlled diet with a moderately high content in protein, produced a slight but statistically significant weight reduction mainly due to the loss of fat mass. An extra Se supplementation (22 μg/day) in the Se-enriched chicken breast did not affect tachyphylactic antioxidant status of the participants neither inflammatory-related markers after weight loss.

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Dietary selenium intake is negatively associated with serum sialic acid and metabolic syndrome features in healthy young adults

Cited by 43 publications

References 41 publications

Nail Antioxidant Trace Elements Are Inversely Associated with Inflammatory Markers in Healthy Young Adults

Nail Antioxidant Trace Elements Are Inversely Associated with Inflammatory Markers in Healthy Young Adults

Dietary Total Antioxidant Capacity: A Novel Indicator of Diet Quality in Healthy Young Adults

Frequent Consumption of Selenium-Enriched Chicken Meat by Adults Causes Weight Loss and Maintains Their Antioxidant Status

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