Dietary saturated fatty acids (12:0, 14:0, 16:0) differ in their impact on plasma cholesterol and lipoproteins in nonhuman primates

Hayes, K. C.; Prończuk, Andrzej; Lindsey, Saralyn; Diersen-Schade, D.A

doi:10.1093/ajcn/53.2.491

Cited by 199 publications

(63 citation statements)

References 32 publications

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“…Therefore, it may be difficult to discriminate whether the increase in cholesterolemia is due to variations in the myristic acid proportions and/or to variations in the P:S ratio. Nevertheless, a previous study [12] has shown that there is no significant difference in the total plasma cholesterol between rhesus monkey fed diets with a similar percentage of myristic acid but with a different P/S ratio. Moreover, in the present study, multiple regression analysis (Tab.…”

Section: Discussionmentioning

confidence: 86%

Increasing amounts of dietary myristic acid modify the plasma cholesterol level and hepatic mass of Scavenger receptor BI without affecting bile acid biosynthesis in hamsters

Loison

Mendy²,

Sérougne

et al. 2002

Reprod. Nutr. Dev.

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-The purpose of this study was to analyze the effects of increasing amounts of dietary myristic acid (0.03 to 4.2% of the total dietary energy) on the plasma and hepatic cholesterol metabolism. Six groups of hamsters received semi-purified diets containing 0.05% cholesterol and 12.5% lipids and differing only by the nature of the triglycerides (Safflower oil, lard, lard/coconut oil (1:1), milk fat, milk fat/coconut oil (1:1), coconut oil) for 3 weeks. A positive regression between the plasma cholesterol level and the dietary myristic acid level was observed (r = 0.60, P < 0.0001). However, it is noteworthy that the increase in plasma total cholesterol only reflects an increase in the level of HDL-cholesterol. In parallel, the mass SR-BI decreased linearly with the increased level of myristic acid in the diet, whereas the LDL-R did not change. This study shows that increasing amounts of myristic acid (0.03 to 4.2%) do not alter the cholesterol or bile acid metabolism and increase only the HDL-C. myristic acid / cholesterol / LDL receptor / SR-B1 / hamsterRésumé -Des doses croissantes d'acide myristique dans l'alimentation modifient la concentration plasmatique du cholestérol et la quantité de SR-BI, sans affecter la biosynthèse des acides biliaires chez le hamster. Le but de cette étude était d'analyser les effets de doses croissantes d'acide myristique (0,03 à 4,2 % de l'apport énergétique total) sur le métabolisme plasmatique et hépatique du cholestérol. Six groupes de hamsters ont reçu des régimes semi-synthétiques contenant 0,05 % de cholestérol et 12,5 % de lipides (carthame, saindoux, saindoux/huile de coco (1:1),

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Section: Discussionmentioning

confidence: 86%

Increasing amounts of dietary myristic acid modify the plasma cholesterol level and hepatic mass of Scavenger receptor BI without affecting bile acid biosynthesis in hamsters

Loison

Mendy²,

Sérougne

et al. 2002

Reprod. Nutr. Dev.

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“…Myristic acid (C14:0), the main responsible for the increase in serum cholesterol concentration (HAYES et al, 1991), was determined as representing 5.76% and 6.96% of fat in the edible portion of the shoulder of castrated and non-castrated lambs, respectively (Table 5). Non-castrated lambs presented, in general, lower cholesterol contents (59.94 mg.100 g -1 ) than castrated lambs (72.52 mg.100 g -1 ) (p = 0.0001).…”

Section: Discussionmentioning

confidence: 99%

Lipidic characterization of Santa Inês lamb shoulder

Cruz¹,

Santos-Cruz²,

Castillo³

et al. 2011

Ciênc. Tecnol. Aliment.

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“…Furthermore, the effects of dietary FA can be modulated by dietary interactions. In non human primates and humans, 12.0 14:0 were more hypercholesterolemic than 16:0 Hayes et al, 1991;Sundram et al, 1991). In addition, in normocholesterolemic humans, dietary 16:0 can be exchanged for 18:1 (by the Table 6 Vitamin E concentrations in oleic acid-rich sun¯ower oil and palmolein and antioxidant vitamin concentrations in the plasma of all women, women with TC`6.21mmolaL (Normocholesterolemic) and women with TC !…”

Section: Serum Lipid Lipoprotein and Apo Concentrationsmentioning

confidence: 99%

Lipoprotein profiles and serum peroxide levels of aged women consuming palmolein or oleic acid-rich sunflower oil diets

et al. 1998

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Objective: To investigate the hypercholesterolemic effects of a dietary exchange between 16:0 and 18:1 while 18:2 was at relatively lower level ( % 4%) in aged women with initially high total serum cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) values and with high intakes of dietary cholesterol. Design: Subjects were assigned to two consecutive 28 d periods. In the ®rst period all subjects followed an oleic acid-rich diet in the form of oleic acid-rich sun¯ower oil. This was followed by a second period rich in palmitic acid in the form of palmolein. Nutrient intakes, serum lipids, lipoproteins, antioxidant vitamins, peroxides and LDL-peroxides were measured at two dietary periods. Setting: Instituto de Nutricio Ân y Bromatologõ Âa (CSIC), Departamento de Nutricio Ân y Bromatologõ Âa I (Nutricio Ân) and Seccio Ân Departamental de Quõ Âmica Analõ Âtica, Universidad Complutense, Madrid, Spain. Results: The palmolein period led to an increase in TC (P`0.001; 17.7%) and serum apolipoprotein (Apo) B levels (P`0.001; 18.0%). LDL-C and LDL-Apo B concentrations were higher (P`0.001, 4.33AE 0.94 mmolaL and P`0.01, 1.08 AE 0.20 gaL, respectively) following this period than following the oleic acid-rich sun¯ower oil diet (3.56 AE 0.85 mmolaL, 0.93 AE 0.16 gaL, respectively). No signi®cant differences were observed in the TCahigh density lipoprotein cholesterol (TCaHDL-C) ratio between the two dietary periods. Serum and LDLperoxides were lower (P`0.01, 49.5%, and P`0.001, 69.0%, respectively) after the palmolein diet than after the oleic acid-rich sun¯ower oil diet. The palmolein diet signi®cantly increased TC, LDL-C, Apo B, VLDLApoB, LDL-ApoB in women with TC ! 6.21 mmolaL or with TC`6.21 mmolaL, but the increase in Apo B, LDL-C and LDL-Apo B was greater among the women with high TC. The palmolein diet increased HDL-C in women with high or with low TC but this rise was on the borderline of statistical signi®cance (P 0.06) only in normocholesterolemics. Serum and LDL-peroxides tended to be higher in women with TC ! 6.21 mmolaL than in women with TC`6.21 mmolaL, but palmolein decreased serum and LDL-peroxide in hypercholesterolemics more than in the normocholesterolemics, resulting in serum and LDL-peroxide levels which theoretically are more adequate. Conclusions: Though palmolein increased LDL-C concentrations, it better protected LDL particles, mainly in women with high TC, against peroxidation than did oleic acid-rich sun¯ower oil. Sponsorship: This study was supported by the Spanish Comision Interministerial de Ciencia Y Tecnologõ Âa

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Dietary saturated fatty acids (12:0, 14:0, 16:0) differ in their impact on plasma cholesterol and lipoproteins in nonhuman primates

Cited by 199 publications

References 32 publications

Increasing amounts of dietary myristic acid modify the plasma cholesterol level and hepatic mass of Scavenger receptor BI without affecting bile acid biosynthesis in hamsters

Increasing amounts of dietary myristic acid modify the plasma cholesterol level and hepatic mass of Scavenger receptor BI without affecting bile acid biosynthesis in hamsters

Lipidic characterization of Santa Inês lamb shoulder

Lipoprotein profiles and serum peroxide levels of aged women consuming palmolein or oleic acid-rich sunflower oil diets

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