Dietary saturate/unsaturate ratio as a determinant of adiposity

McCarty, Mark F.

doi:10.1016/j.mehy.2009.12.021

Cited by 10 publications

(4 citation statements)

References 72 publications

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“…In addition to its down-regulatory impact on plasma IGF-I, a whole-food plant-based diet, consumed ad libitum, tends to promote leanness and good insulin sensitivity [41,42] -possibly in part because such diets have a low saturate-unsaturate ratio [43].…”

Section: Igf-i Bioactivity As a Determinant Of Riskmentioning

confidence: 99%

“…The considerations cited above suggest that a plant-based diet of moderate protein content, via down-regulation of serum IGF-I, may notably reduce BPH risk. Measures which minimize diurnal insulin secretion -such as leanness, exercise training, a low dietary saturate/ unsaturate ratio, [43] and low-glycemic-index food choices -may also reduce this risk by decreasing the effective activity of IGFs. Frequent consumption of soy isoflavones may promote apoptosis in prostate tissue by selective activation of ER-β.…”

Section: Summary -Potential Of Diet/lifestyle Strategies For Bph Prevmentioning

confidence: 99%

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Diet/Lifestyle Strategies for Preventing Benign Prostatic Hyperplasia

McCarty¹

2014

J Metabolic Synd

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Section: Igf-i Bioactivity As a Determinant Of Riskmentioning

confidence: 99%

Section: Summary -Potential Of Diet/lifestyle Strategies For Bph Prevmentioning

confidence: 99%

Diet/Lifestyle Strategies for Preventing Benign Prostatic Hyperplasia

McCarty¹

2014

J Metabolic Synd

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“…An epidemiological study in Loma Linda, which has a high population of vegetarians, found that, after multivariate adjustment including BMI, long-term vegans, as opposed to omnivores, were 62% less likely to develop type 2 diabetes, without adjustment for BMI (which tends to be low in vegans), and 77% protection was observed [ 105 ]. The low proportion of total dietary fat provided as saturated fat in most vegan diets may also provide protection in this regard by improving peripheral insulin sensitivity and hence lessening glucose/lipid overexposure [ 106 ].…”

Section: Controlling Beta Cell Oxidant Stress—focus On Nox2 Mitophagy and Mitochondrial Biogenesismentioning

confidence: 99%

Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity—Nutraceutical Options

McCarty

DiNicolantonio

2021

Healthcare

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In people with metabolic syndrome, episodic exposure of pancreatic beta cells to elevated levels of both glucose and free fatty acids (FFAs)—or glucolipotoxicity—can induce a loss of glucose-stimulated insulin secretion (GSIS). This in turn can lead to a chronic state of glucolipotoxicity and a sustained loss of GSIS, ushering in type 2 diabetes. Loss of GSIS reflects a decline in beta cell glucokinase (GK) expression associated with decreased nuclear levels of the pancreatic and duodenal homeobox 1 (PDX1) factor that drives its transcription, along with that of Glut2 and insulin. Glucolipotoxicity-induced production of reactive oxygen species (ROS), stemming from both mitochondria and the NOX2 isoform of NADPH oxidase, drives an increase in c-Jun N-terminal kinase (JNK) activity that promotes nuclear export of PDX1, and impairs autocrine insulin signaling; the latter effect decreases PDX1 expression at the transcriptional level and up-regulates beta cell apoptosis. Conversely, the incretin hormone glucagon-like peptide-1 (GLP-1) promotes nuclear import of PDX1 via cAMP signaling. Nutraceuticals that quell an increase in beta cell ROS production, that amplify or mimic autocrine insulin signaling, or that boost GLP-1 production, should help to maintain GSIS and suppress beta cell apoptosis in the face of glucolipotoxicity, postponing or preventing onset of type 2 diabetes. Nutraceuticals with potential in this regard include the following: phycocyanobilin—an inhibitor of NOX2; agents promoting mitophagy and mitochondrial biogenesis, such as ferulic acid, lipoic acid, melatonin, berberine, and astaxanthin; myo-inositol and high-dose biotin, which promote phosphatidylinositol 3-kinase (PI3K)/Akt activation; and prebiotics/probiotics capable of boosting GLP-1 secretion. Complex supplements or functional foods providing a selection of these agents might be useful for diabetes prevention.

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“…This process can prolong the lifespan of rodents; notably, this process can also be achieved by dieting . With the same fat intake, a diet containing high amounts of saturated fat is more likely to cause obesity; by contrast, a vegetarian diet can facilitate weight loss among individuals because of high unsaturated fatty acid content and incomplete essential amino acid profile .…”

Section: Physiological Environment Diet and Exercisementioning

confidence: 99%

Stochastic effects in adaptive reconstruction of body damage: implied the creativity of natural selection

Xiao

Cui

Chen

et al. 2015

J Cellular Molecular Medi

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After an injury occurs, mechanical/biochemical loads on muscles influence the composition and structure of recovering muscles; this effect likely occurs in other tissues, cells and biological molecules as well owing to the similarity, interassociation and interaction among biochemical reactions and molecules. The ‘damage and reconstruction’ model provides an explanation for how an ideal cytoarchitecture is created by reducing components not suitable for bearing loads; in this model, adaptive changes are induced by promoting the stochasticity of biochemical reactions. Biochemical and mechanical loads can direct the stochasticity of biochemical reactions, which can in turn induce cellular changes. Thus, mechanical and biochemical loads, under natural selection pressure, modify the direction of cell- and tissue-level changes and guide the formation of new structures and traits, thereby influencing microevolution. In summary, the ‘damage and reconstruction’ model accounts for the role of natural selection in the formation of new organisms, helps explain punctuated equilibrium, and illustrates how macroevolution arises from microevolution.

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Dietary saturate/unsaturate ratio as a determinant of adiposity

Cited by 10 publications

References 72 publications

Diet/Lifestyle Strategies for Preventing Benign Prostatic Hyperplasia

Diet/Lifestyle Strategies for Preventing Benign Prostatic Hyperplasia

Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity—Nutraceutical Options

Stochastic effects in adaptive reconstruction of body damage: implied the creativity of natural selection

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