Dietary Restriction of Single Essential Amino Acids Reduces Plasma Insulin-Like Growth Factor-I (IGF-I) but Does Not Affect Plasma IGF-Binding Protein-1 in Rats

Takenaka, Asako; Oki, Noriko; Takahashi, Shinichiro; Noguchi, Tadashi

doi:10.1093/jn/130.12.2910

Cited by 63 publications

(52 citation statements)

References 22 publications

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“…That the dietary lysine deficiency decreased the plasma IGF-1 concentration in the finishing pigs of this study supports the research conducted by Takenaka et al [36] and Katsumata et al [18], who showed that the plasma IGF-1 concentration was reduced when young rats (6 weeks of age) and nursery pigs were fed the diets lower in lysine. The previous studies on growing pigs, however, did not show that dietary lysine levels influence the plasma concentration of IGF-1 [14,17].…”

Section: Lysine Effects On the Plasma Concentrations Of Growth Hormonsupporting

confidence: 91%

Effects of Dietary Lysine Levels on the Plasma Concentrations of Growth‐Related Hormones in Late‐Stage Finishing Pigs

Wang¹,

Crenshaw²,

Hasan³

et al. 2017

Amino Acid - New Insights and Roles in Plant and Animal

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This study was undertaken to investigate the effects of dietary lysine on the plasma concentrations of three growth-related hormones in pigs. Nine late-stage finishing barrows were assigned to three dietary treatments according to a completely randomized experimental design (3 pigs/treatment). Three corn and soybean meal-based diets were formulated to contain three levels of lysine, which were 0.43, 0.71, and 0.98% for Diets 1 (lysine deficient), 2 (lysine adequate), and 3 (lysine excess), respectively. The feeding trial lasted 4 weeks, during which the pigs were allowed ad libitum access to the diets and water. After the 4 weeks, blood was collected and plasma samples were obtained. Then, the plasma concentrations of insulin, growth hormone (GH), and insulin-like growth factor 1 (IGF-1) were measured. No difference in the plasma concentration of insulin or GH among the three treatments was found (P > 0.10). However, the plasma IGF-1 concentration was lower (P < 0.05) in the pigs fed Diet 1 or 3 than fed Diet 2, suggesting that either dietary lysine deficiency or excess can lead to a lower concentration of plasma IGF-1. It was concluded that IGF-1, instead of insulin or GH, in the blood may be a key controlling growth factor in response to dietary lysine supply for regulating muscle growth in late-stage finishing pigs.

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Section: Lysine Effects On the Plasma Concentrations Of Growth Hormonsupporting

confidence: 91%

Effects of Dietary Lysine Levels on the Plasma Concentrations of Growth‐Related Hormones in Late‐Stage Finishing Pigs

Wang¹,

Crenshaw²,

Hasan³

et al. 2017

Amino Acid - New Insights and Roles in Plant and Animal

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“…However, fasting still poses a challenge to patients, which calls for an urgent need of substitution diets or targeted drugs that can mimic fasting. Experimental evidence from aging research suggests that diets with specific deficiencies, especially essential amino acids, may provide increased stress resistance and lifespan (Richie et al, 1994;Takenaka et al, 2000;Harper et al, 2006). Although, it is unlikely that the vast effects caused by fasting can be obtained with specific deficiencies, it will be important to determine whether limitations of specific nutrients will be sufficient to promote some of the effects of fasting.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

2011

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“…Insulin also decreases hepatic production of IGF binding proteins (IGFBP), notably IGFBP-1, a key antagonist of IGF-1 action (Ritvos et al, 1988;Lewitt et al, 1991). In Wistar rats, short-term dietary restriction of single essential amino acids reduces plasma IGF-1 but does not increase IGFBP-1 levels except in those animals that are methionine restricted or feeding on diets devoid of amino acids (Tanenaka et al, 2000). Thus, it is plausible in MR that the observed lower insulin levels contributed to the reduced IGF-1 levels and that increased IGFBP-1 might have been a consequence of this action.…”

Section: Discussionmentioning

confidence: 99%

Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction

et al. 2006

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SummaryReduced dietary methionine intake (0.17% methionine, MR) and calorie restriction (CR) prolong lifespan in male Fischer 344 rats. Although the mechanisms are unclear, both regimens feature lower body weight and reductions in adiposity. Reduced fat deposition in CR is linked to preservation of insulin responsiveness in older animals. These studies examine the relationship between insulin responsiveness and visceral fat in MR and test whether, despite lower food intake observed in MR animals, decreased visceral fat accretion and preservation of insulin sensitivity is not secondary to CR. Accordingly, rats pair fed (pf) control diet (0.86% methinone, CF) to match the food intake of MR for 80 weeks exhibit insulin, glucose, and leptin levels similar to control-fed animals and comparable amounts of visceral fat. Conversely, MR rats show significantly reduced visceral fat compared to CF and PF with concomitant decreases in basal insulin, glucose, and leptin, and increased adiponectin and triiodothyronine. Daily energy expenditure in MR animals significantly exceeds that of both PF and CF. In a separate cohort, insulin responses of older MR animals as measured by oral glucose challenge are similar to young animals. Longitudinal assessments of MR and CF through 112 weeks of age reveal that MR prevents age-associated increases in serum lipids. By 16 weeks, MR animals show a 40% reduction in insulin-like growth factor-1 (IGF-1) that is sustained throughout life; CF IGF-1 levels decline much later, beginning at 112 weeks. Collectively, the results indicate that MR reduces visceral fat and preserves insulin activity in aging rats independent of energy restriction.

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Dietary Restriction of Single Essential Amino Acids Reduces Plasma Insulin-Like Growth Factor-I (IGF-I) but Does Not Affect Plasma IGF-Binding Protein-1 in Rats

Cited by 63 publications

References 22 publications

Effects of Dietary Lysine Levels on the Plasma Concentrations of Growth‐Related Hormones in Late‐Stage Finishing Pigs

Effects of Dietary Lysine Levels on the Plasma Concentrations of Growth‐Related Hormones in Late‐Stage Finishing Pigs

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction

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