Dietary Protein Intake in Relation to the Risk of Osteoporosis in Middle-Aged and Older Individuals: A Cross-Sectional Study

Zhang, Y.-W.; Cao, Mu-Min; Li, Y.-J.; Dai, Guang-Chun; Lu, Panpan; Zhang, M.; Bai, Li-yong; Chen, X.-X.; Shi, Liu; Zhang, Cheng; Menemenlis, Dimitris

doi:10.1007/s12603-022-1748-1

Cited by 17 publications

(17 citation statements)

References 39 publications

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“…Therein, the brittle fractures caused by osteoporosis mainly occur in stress concentration parts, including the vertebral bodies, hip and distal radius, which significantly enhances the disability rate and the mortality of the middle-aged and elderly individuals [3][4][5]. Moreover, in accordance with previous studies, more than 150 million individuals worldwide suffer from osteoporosis every year, and one-third of women and one-fifth of men around the world might suffer from osteoporotic fractures at least once during their whole life [6,7], which is a major challenge for the patients themselves, their families and social medical security system [8,9].…”

Section: Introductionsupporting

confidence: 56%

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Zhang

Cao

et al. 2022

J Bone Miner Metab

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Osteoporosis is a systemic metabolic bone disease characterized by the descending bone mass and destruction of bone microstructure, which tends to result in the increased bone fragility and associated fractures, as well as high disability rate and mortality. The relation between gut microbiota and bone metabolism has gradually become a research hotspot, and it has been verified that gut microbiota is closely associated with reduction of bone mass and incidence of osteoporosis recently. As a novel "organ transplantation" technique, fecal microbiota transplantation (FMT) mainly refers to the transplantation of gut microbiota from healthy donors to recipients with gut microbiota imbalance, so that the gut microbiota in recipients can be reshaped and play a normal function, and further prevent or treat the diseases related to gut microbiota disorder. Herein, based on the gut-bone axis and proven regulatory effects of gut microbiota on osteoporosis, this review expounds relevant basic researches and clinical practice of FMT on osteoporosis, thus demonstrating the potentials of FMT as a therapeutic option for osteoporosis and further providing certain reference for the future researches.

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Section: Introductionsupporting

confidence: 56%

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Zhang

Cao

et al. 2022

J Bone Miner Metab

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“…With the prolongation of the life span of population around world, osteoporosis and related osteoporotic fractures impose a growing burden on the social medical system 1,29‐31 . Moreover, SII is an index derived from the number of various inflammatory cell subsets according to a specific equation 32 .…”

Section: Discussionmentioning

confidence: 99%

High systemic immune‐inflammation index is relevant to osteoporosis among middle‐aged and older people: A cross‐sectional study

Zhang,

2023

Immunity Inflam & Disease

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BackgroundAs one of novel inflammatory indexes proposed in recent years, systemic immune‐inflammation index (SII) can comprehensively reflect the inflammatory and immune state of the body. This study aims to explore the relationship between SII and osteoporosis among middle‐aged and older people.Materials and MethodsOur study includes 20,497 individuals from National Health and Nutrition Examination Survey (NHANES) 2005–2008, and target study population are confined to people aged 45 years and above. SII is calculated as platelet count × neutrophil count/lymphocyte count. Multivariate logistic regression analysis is used to explore the link between SII and osteoporosis, and receiver operating characteristics curve is used to screen optimal cut‐off value of SII for indicating the occurrence of osteoporosis.ResultsA total of 435 people with osteoporosis are screened among 4625 middle‐aged and older people, and individuals in osteoporosis group have higher SII than those in nonosteoporosis group (p = .024). Logistic regression analysis indicates that with the enhancement of SII, prevalence of osteoporosis in each tertile category also increases (p < .001). This tendency is also not changed in univariate model (p < .001), as well as the adjustments for different parameters. Moreover, we also identify that SII of 530.09 is the optimal cut‐off value for indicating the occurrence of osteoporosis among middle‐aged and older people.ConclusionsThis present NHANES‐based study noticed that higher SII is positively linked to osteoporosis among middle‐aged and older people, and SII should not exceed 530.09 for them to obtain a potentially lower risk of osteoporosis.

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“…Ultimately, our current study also has the following potential limitations. (1) The postoperative follow-up period included in this current study was rather short and longterm follow-up studies should be performed to compare the long-dated effects of GA and RA; (2) walking ability was an important outcome but was not included in our current study due to the limited number of studies; and (3) publication bias is an inherent flaw of all meta-analyses.…”

Section: Discussionmentioning

confidence: 99%

General Anesthesia Versus Regional Anesthesia in the Elderly Patients Undergoing Hip Fracture Surgeries: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials

et al. 2023

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Background Surgery is the preferred treatment option for the elderly patients with hip fractures. However, the choice of general anesthesia (GA) or regional anesthesia (RA) remains controversial. The quality of evidence has further improved with the advent of several high‐quality randomized clinical trials (RCTs) in the last two years. The purpose of this study was to compare the clinical outcomes of two anesthetic techniques in elderly patients undergoing hip fracture surgeries. Methods Eligible studies were identified from PubMed/MEDLINE, Web of Science, Scopus, EMBASE and reference lists from January 2000 to June 2022 in this current systematic review and meta‐analysis. The outcomes included the surgery‐related outcomes (duration of surgery, duration of anesthesia, intraoperative blood loss and number of transfusions) and postoperative outcomes (30‐day mortality, postoperative delirium,cardiovascular events and other complications). Results A total of 10 RCTs were included, and a total of 3594 patients were analyzed. RA was associated with shorter duration of surgery, shorter length of hospital stays and less intraoperative blood loss compared to GA. There were no significant differences between the two groups in the number of blood transfusions, duration of anesthesia, 30‐day mortality or postoperative delirium. Conclusions Our pooled analysis identified no significant differences in terms of the safety between RA and GA, while RA reduces intraoperative blood loss, length of hospital stays and duration of surgery. These results suggest that RA appears to be preferable for the elderly patients with hip fractures.

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Dietary Protein Intake in Relation to the Risk of Osteoporosis in Middle-Aged and Older Individuals: A Cross-Sectional Study

Cited by 17 publications

References 39 publications

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Fecal microbiota transplantation as a promising treatment option for osteoporosis

High systemic immune‐inflammation index is relevant to osteoporosis among middle‐aged and older people: A cross‐sectional study

General Anesthesia Versus Regional Anesthesia in the Elderly Patients Undergoing Hip Fracture Surgeries: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials

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