High systemic immune‐inflammation index is relevant to osteoporosis among middle‐aged and older people: A cross‐sectional study

Abstract

BackgroundAs one of novel inflammatory indexes proposed in recent years, systemic immune‐inflammation index (SII) can comprehensively reflect the inflammatory and immune state of the body. This study aims to explore the relationship between SII and osteoporosis among middle‐aged and older people.Materials and MethodsOur study includes 20,497 individuals from National Health and Nutrition Examination Survey (NHANES) 2005–2008, and target study population are confined to people aged 45 years and above. SII is calculated as platelet count × neutrophil count/lymphocyte count. Multivariate logistic regression analysis is used to explore the link between SII and osteoporosis, and receiver operating characteristics curve is used to screen optimal cut‐off value of SII for indicating the occurrence of osteoporosis.ResultsA total of 435 people with osteoporosis are screened among 4625 middle‐aged and older people, and individuals in osteoporosis group have higher SII than those in nonosteoporosis group (p = .024). Logistic regression analysis indicates that with the enhancement of SII, prevalence of osteoporosis in each tertile category also increases (p < .001). This tendency is also not changed in univariate model (p < .001), as well as the adjustments for different parameters. Moreover, we also identify that SII of 530.09 is the optimal cut‐off value for indicating the occurrence of osteoporosis among middle‐aged and older people.ConclusionsThis present NHANES‐based study noticed that higher SII is positively linked to osteoporosis among middle‐aged and older people, and SII should not exceed 530.09 for them to obtain a potentially lower risk of osteoporosis.

Systemic immune-inflammation Index is associated with chronic kidney disease in the U.S. population: insights from NHANES 2007–2018

“…Most importantly, SII has been shown in many studies to be more responsive to the body’s inflammatory state and to have greater prognostic value than other inflammatory markers ( 8 , 9 , 33 , 34 ). As previously described, SII was initially used primarily in oncology patients, however, with further research it also is strongly associated with other diseases such as osteoporosis among middle-aged and older people ( 35 ), ulcerative colitis ( 36 ), metabolic syndrome ( 37 ), heart failure ( 38 ), periodontitis ( 16 ), chronic obstructive pulmonary disease ( 14 ), coronary heart disease ( 39 ), hyperlipidemia ( 40 ), cognitive impairment ( 41 ), rheumatoid arthritis ( 42 ) and depression ( 15 ).…”

Prognostic value of the systemic immune-inflammation index in critically ill elderly patients with hip fracture: evidence from MIMIC (2008–2019)

“…Numerous clinical studies have delved into the association between SII and the incidence as well as mortality rates of fractures and complications across the general populace and diverse patient categories. Zhang et al ( 32 ) reported that there exists an association between increased SII and an increased vulnerability to systemic inflammation as well as osteoporosis in middle-aged and elderly populations. Fang et al ( 33 ) found that monitoring changes in SII could play a role in predicting osteoporotic fractures.…”

Correlation study: Bone density and circulating inflammatory markers in postmenopausal patients

“…The SII can comprehensively reflect the inflammatory and immune state of the body, as one of the novel inflammatory indexes proposed in recent years. 25 In a previous study by Lu et al, SII was defined as a new index for evaluating immunity and inflammation, which was obtained by the platelet count × neutrophil count/lymphocyte count. Higher SII indicated that patients had stronger inflammation and weaker immune response.…”