Dietary Protein as a Potent Regulator of the Hyaluronan Synthase Gene in Rat Skin

Oishi, Yoshifumi; Kato, Harubumi; Noguchi, Tadashi

doi:10.1271/bbb.67.736

Cited by 19 publications

(17 citation statements)

References 42 publications

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“…Each essential AA deficiency resulted in a pronounced decrease in hyaluron production in WS1 cells. In our previous study, we revealed that the expression of the HAS2 gene was highly sensitive to the quantity and quality of the dietary protein (Oishi et al, 2003). Taken together, our results suggest that such dietary patterns may lead to skin dysfunction and various cutaneous diseases.…”

Section: Discussionsupporting

confidence: 57%

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Effects of an Amino acid Deficiency on Hyaluronan Synthesis in Human Dermal Fibroblasts

Yamane

Inoue

Kobayashi‐Hattori

et al. 2016

FSTR

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Molecules involved in skin function are greatly affected by nutritional conditions. However, the mechanism linking amino acid (AA)s with these alterations is not well understood. We examined the effects of an AA deficiency on hyaluronan synthesis in human dermal fibroblasts. A deficiency of all AAs or of valine, leucine, isoleucine, threonine, methionine, cysteine, phenylalanine, tyrosine, tryptophan, lysine, arginine, histidine, or glutamine significantly decreased hyaluronan levels in the culture supernatant. The deficiencies of all AAs, valine, leucine, cysteine or glutamine tended to decrease hyaluronan synthase 2 mRNA levels in human dermal fibroblasts. The present study would contribute to the elucidation of the mechanisms underlying the effects of AAs on skin function.

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Section: Discussionsupporting

confidence: 57%

“…We previously demonstrated that hyaluronan synthesis was down-regulated by a low quality of dietary protein, such as gluten (Oishi et al, 2003). The quality of dietary protein can be estimated AAs and Gln is a key factor for the enhancement of skin collagen synthesis in protein-malnourished rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of an Amino acid Deficiency on Hyaluronan Synthesis in Human Dermal Fibroblasts

Yamane

Inoue

Kobayashi‐Hattori

et al. 2016

FSTR

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“…Real-time PCR reactions were conducted using the ABI Prism 7000 Sequence Detection System (Applied Biosystems Japan Ltd., Tokyo, Japan) with TaqMan ® Universal PCR Master Mix (Applied Biosystems Japan). The primers and probes of β-actin (used as an internal control) were synthesized according to the method described by Oishi et al (2003). The primers and probes of UCP1 and Adrb3 were TaqMan ® Gene Expression Assays (Applied Biosystems Japan).…”

Section: Quantitative Real-time Polymerase Chain Reaction (Pcr) Totalmentioning

confidence: 99%

Anti-obesity Effects of Wasabi Leaf Extract on Rats Fed a High-fat Diet are Related to Upregulation of mRNA Expression of β3-adrenergic Receptors in Interscapular Brown Adipose Tissue

Yamada‐Kato¹,

Momoi

Okunishi³

et al. 2016

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Wasabi is a plant of Japanese origin belonging to the Brassicaceae family. Although the wasabi rhizome is a popular condiment in Japan, the leaf is typically discarded. For utilization of the wasabi leaf, we investigated its antiobesity effect on Wistar rats fed a high-fat diet containing wasabi leaf extract (WLE) prepared with 50% ethanol.At the experimental endpoint, WLE had significantly decreased the body weight of rats and upregulated the mRNA expression of the β3-adrenergic receptor (Adrb3) in the interscapular brown adipose tissue (BAT). WLE may have promoted lipid absorption from the dietary fat, as the fecal lipid content was considerably lower in the WLE group. These results suggest that WLE suppressed obesity in rats fed a high-fat diet, which was related to the upregulation of Adrb3 mRNA expression in the interscapular BAT without increased fecal lipid excretion. Thus, wasabi leaves may be used as a functional food material for the suppression of obesity.

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“…Extraction of total RNA and synthesis of complementary DNA were performed as described previously. 12) Quantitative PCR primers and hybridization probes were synthesized by Applied Biosystems (Foster, IN). The oligonucleotide primers of IGFBP-1 were designed to amplify nucleo- A time course analysis indicated that the production of IGFBP-1 was increased significantly in HepG2 cells exposed to a 3 mM Cd 2þ for 72 and 144 h (data not shown).…”

Section: )mentioning

confidence: 99%

Cadmium Cation Increases the Production and mRNA Levels of Insulin-Like Growth Factor-Binding Protein-1 in HepG2

Oishi

Ohnishi

Kobayashi‐Hattori

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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Dietary Protein as a Potent Regulator of the Hyaluronan Synthase Gene in Rat Skin

Cited by 19 publications

References 42 publications

Effects of an Amino acid Deficiency on Hyaluronan Synthesis in Human Dermal Fibroblasts

Effects of an Amino acid Deficiency on Hyaluronan Synthesis in Human Dermal Fibroblasts

Anti-obesity Effects of Wasabi Leaf Extract on Rats Fed a High-fat Diet are Related to Upregulation of mRNA Expression of β3-adrenergic Receptors in Interscapular Brown Adipose Tissue

Cadmium Cation Increases the Production and mRNA Levels of Insulin-Like Growth Factor-Binding Protein-1 in HepG2

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