Anti-obesity Effects of Wasabi Leaf Extract on Rats Fed a High-fat Diet are Related to Upregulation of mRNA Expression of β3-adrenergic Receptors in Interscapular Brown Adipose Tissue

Yamada‐Kato, Tomoe; Momoi, Saori; Okunishi, Isao; Minami, Motoyasu; Oishi, Yoshifumi; Osawa, Toshihiko; Naito, Michitaka

doi:10.3136/fstr.22.665

Cited by 8 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result that suppression of oxidative stress and regulation of postprandial hyperglycemia are pivotal to the management of diabetes [15,16], many attempts have been made to find effective antioxidants and α-glucosidase inhibitors from natural materials to develop physiologically functional foods or lead compounds to cure diabetes [16][17][18]. Among these candidate compounds, natural extracts (including wasabi leaf (WL)) have antioxidant, anti-inflammatory, and anti-obesity effects [19,20].…”

Section: Introductionmentioning

confidence: 99%

“…Most of the reported studies have focused the antimicrobial [22], antioxidative [23], and anti-carcinogenic activities [24] of isothiocyanate. However, there are few studies investigating the functional properties of other components in wasabi, particularly in its summer leaves, which are considered late-growth with minimal pungency [25], and anti-obesity effects of wasabi leaf in mice [21] and rats [20] fed a high-fat diet (HFD) have been reported with in vitro assay [19]. In this study, we investigated the efficacy of WL in 45% Kcal high-fat diet (HFD)-fed mice, compared with metformin treatment, a representative anti-diabetic and anti-obesity drug used to treat type II diabetes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Choi¹,

Kim

Lee

et al. 2020

Nutrients

View full text Add to dashboard Cite

The present study examined the effects of Wasabi leaf (WL) on 45% Kcal high-fat diet (HFD)-fed mild diabetic obese mice. In particular, the hepatoprotective (i.e., liver weight, histopathology of liver, serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase) effects of 12 weeks of continuous oral administration of 250 mg/kg metformin, and 200, 100, or 50 mg/kg WL were investigated. In addition, the hypolipidemic (i.e., serum triglyceride, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein levels), hypoglycemic (i.e., glycated hemoglobin, blood glucose and insulin levels, pancreatic weight, and immunohistochemical-histopathological analysis of the pancreas), and anti-obesity effects (i.e., body weight, mean food consumption, total and abdominal body fat mass, periovarian fat weight, and histopathology of the periovarian and abdominal wall adipocytes) were monitored. The liver and general antioxidant defense systems were also assessed by lipid metabolism-related gene expression. All diabetes manifestations and related complications, including obesity and non-alcoholic fatty liver disease (NAFLD), were dose-dependently reduced after 84 days of oral treatment with metformin or each of the three dosages of WL. In particular, 50 mg/kg WL showed effective suppression effects against HFD-induced diabetes and related complications of obesity, NAFLD, and hyperlipidemia, comparable to the effects of metformin.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Choi¹,

Kim

Lee

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…Hiperglycemia and dyslipidemia in type 2 diabetes disturb functionality mainly of such organs and tissues such as pancreas, liver, kidney, skeletal muscles and fat tissue. Lately, the in vivo study of Yamada-Kato et al [12] demonstrated that wasabi leaf which, contains very high amounts of AITC, suppressed obesity in rats fed a high-fat diet (HFD) due to the upregulation of expression of β 3 adrenergic receptors in brown adipose tissue. When mice were given AITC in addition to HFD, they were protected from body weight gains, organ hypertrophy, dyslipidemia and hepatic steatosis through the modulation of mitochondrial activity [13].…”

Section: Introductionmentioning

confidence: 99%

Differentiated Effects of Allyl Isothiocyanate in Diabetic Rats: From Toxic to Beneficial Action

Okulicz

Hertig

Szkudelski

2021

Toxins

View full text Add to dashboard Cite

Allyl isothiocyanate (AITC), a constituent of Brassica family plants, has been reported to possess a high bioactivity in animal and human cells, showing ambiguous properties from adverse to beneficial ones. It was reported its genotoxic, carcinogenic, goitrogenic effects. On the other side, AITC has shown anti-cancer, cardioprotective, neuroprotective, and lately anti-obesity abilities. So far, its anti-diabetic effects are poorly explored. We tried to assess AITC action on carbohydrate, lipid and hormonal disorders in high fat diet-fed/streptozotocin diabetic rats. In this report, diabetic rats were treated intragastrically at doses 2.5, 5 and 25 mg/kg b.w./day of AITC for 2 weeks. Irrespectively of doses, AITC considerably lowered thyroid hormones (fT4, fT3), increased liver TG content, and also caused robust LDL-cholesterol and direct bilirubin concentration enhancement. Moreover, AITC at the highest dose caused pancreatic amylase and lipase drops and thyroid gland hypertrophy. AITC at 2.5 and 5 mg significantly reduced blood glucose levels along with robust beta-hydroxybutyric acid drop. Additionally, AITC at 5 mg improved insulin sensitivity (HOMA-IR index) in spite of reduced blood insulin. To conclude, despite amelioration of diabetic hyperglycemia by AITC, the adverse lipids and hormonal effects may exclude its use as a health-promoting compound in terms of anti-diabetic properties.

show abstract

“…Furthermore, Yamasaki et al () reported that hot‐water extract of wasabi leaves exhibited an anti‐obesity effect in a study using C57/BL mice. Additionally, Yamada‐Kato et al () reported that 50% ethanol extract of wasabi leaves showed an anti‐obesity effect via upregulation of the mRNA expression of β3‐adrenergic receptor (β3AR) in interscapular brown adipose tissue. These studies have boosted interest in the potential beneficial effects of wasabi leaves, including those against obesity.…”

Section: Introductionmentioning

confidence: 99%

5‐Hydroxyferulic acid methyl ester isolated from wasabi leaves inhibits 3T3‐L1 adipocyte differentiation

Misawa

Hosoya

Yoshida

et al. 2018

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

To investigate the compounds present in wasabi leaves (Wasabia japonica Matsumura) that inhibit the adipocyte differentiation, activity-guided fractionation was performed on these leaves. 5-Hydroxyferulic acid methyl ester (1: 5-HFA ester), one of the phenylpropanoids, was isolated from wasabi leaves as a compound that inhibits the adipocyte differentiation. Compound 1 suppressed the intracellular lipid accumulation of 3T3-L1 cells without significant cytotoxicity. Gene expression analysis revealed that 1 suppressed the mRNA expression of 2 master regulators of adipocyte differentiation, PPARγ and C/EBPα. Furthermore, 1 downregulated the expression of adipogenesis-related genes, GLUT4, LPL, SREBP-1c, ACC, and FAS. Protein expression analysis revealed that 1 suppressed PPARγ protein expression. Moreover, to investigate the relationship between the structure and activity of inhibiting the adipocyte differentiation, we synthesized 12 kinds of phenylpropanoid analog. Comparison of the activity among 1 and its analogs suggested that the compound containing the substructure that possess a common functional group at the ortho position such as a catechol group exhibits the activity of inhibiting the adipocyte differentiation. Taken together, our findings suggest that 1 from wasabi leaves inhibits adipocyte differentiation via the downregulation of PPARγ.

show abstract

Anti-obesity Effects of Wasabi Leaf Extract on Rats Fed a High-fat Diet are Related to Upregulation of mRNA Expression of β3-adrenergic Receptors in Interscapular Brown Adipose Tissue

Cited by 8 publications

References 38 publications

Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Differentiated Effects of Allyl Isothiocyanate in Diabetic Rats: From Toxic to Beneficial Action

5‐Hydroxyferulic acid methyl ester isolated from wasabi leaves inhibits 3T3‐L1 adipocyte differentiation

Contact Info

Product

Resources

About