Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus

El-Adawy, Mohammed; El-Aziz, Magdy Abd; El-Shazly, Kamal; Ali, Nadia Gabr; El-Magd, Mohammed A.

doi:10.1007/s11356-018-3206-5

Cited by 42 publications

(23 citation statements)

References 32 publications

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“…No alterations in most hematological values except for a decrease in hematocrit and thrombocyte count were observed in Oreochromis niloticus fed a diet containing 500 mg/kg of OTC for 2 weeks [24]. No changes in the values of most hematological parameters and thrombocytosis in the same species fed a similar diet for 60 days were reported by El-Adawy et al [25]. A short-term increase in erythrocyte and leukocyte counts in Sparus aurata after dietary administration of 75 mg/kg of OTC for 10 days was reported by Serezli et al [26].…”

Section: Introductionmentioning

confidence: 58%

Effects of Oxytetracycline and Gentamicin Therapeutic Doses on Hematological, Biochemical and Hematopoietic Parameters in Cyprinus carpio Juveniles

Kondera

Bojarski

Ługowska

et al. 2020

Animals

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Hematological, biochemical and hematopoietic effects of therapeutic doses of two antibiotics, oxytetracycline (OTC) and gentamicin (GEN), in clinically healthy common carp juveniles were studied. The fish were divided into four groups: controls 1 and 2 (untreated or injected with 0.6% NaCl solution), and two groups treated with antibiotics (orally with 75 mg/kg OTC four times every two days or injected with a single dose (4 mg/kg) of GEN dissolved in 0.6% NaCl). Blood and head kidneys were sampled from all fish 3 days post-treatments for hematological, biochemical and hematopoietic tissue analyses. No major alterations in the values of hematological and serum biochemical parameters occurred following administration of OTC or GEN. Glucose concentrations were significantly lower in both groups of fish subjected to injections (Control 2 and GEN), while the oxidative metabolic activity of phagocytes increased in the antibiotic-treated groups (significantly in OTC). More alterations were observed in hematopoietic tissue. Immunocytochemical analysis revealed that G caused a significant increase in the rate of cell proliferation (PCNA-positive cells) and an increase in the frequency of apoptotic cells (caspase-positive). The frequency of lymphoid lineage decreased, which was related to a decrease in the abundance of mature lymphocytes in GEN-treated fish. Percentages of neutrophilic lineage were significantly elevated in OTC and GEN groups compared to controls. The obtained results showed no considerable hematotoxicity or hepatotoxicity of therapeutic doses of OTC and GEN to carp.

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Section: Introductionmentioning

confidence: 58%

Effects of Oxytetracycline and Gentamicin Therapeutic Doses on Hematological, Biochemical and Hematopoietic Parameters in Cyprinus carpio Juveniles

Kondera

Bojarski

Ługowska

et al. 2020

Animals

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“…Analysis of blood parameters is an important tool used to assess the toxic effects of xenobiotics on fish [ 80 , 81 ]. However, most available data concerning hematological effects of antibacterials in fish regard mainly oxytetracycline [ 82 , 83 , 84 , 85 , 86 , 87 ] and very little information about other antibacterials were found ( Table 2 ). In all these studies fish were subjected to relatively high doses administered via diet or injection.…”

Section: Toxic Effects Of Antibacterials On Fish Organismsmentioning

confidence: 99%

“…Little is known also about the influence of antibacterials on the biochemical indices of plasma or serum, and the data published so far are mostly focused on the effects of oxytetracycline [ 82 , 83 , 84 , 88 , 89 ]. Analysis of the available data ( Table 2 ) shows that activities of hepatic enzymes (ALT and AST) in fish exposed to oxytetracycline often increased, which may indicate a hepatotoxic effect of this antibiotic in fish.…”

Section: Toxic Effects Of Antibacterials On Fish Organismsmentioning

confidence: 99%

Antibacterials in Aquatic Environment and Their Toxicity to Fish

2020

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Antibacterial agents are commonly present in aquatic environment at low concentrations. Terrestrial animal farms, human medicine and aquaculture are main sources of water contamination with antibacterials. Antibiotics were proved to be directly toxic to fish causing oxidative stress, general stress response, histopathological lesions, hematological, metabolic, and reproductive disorders, as well as immunosuppressive and genotoxic effects. Environmentally realistic low concentrations of antibiotics also disturb aquatic bacterial communities causing alterations in fish symbiotic microbiota and induce emergence of antibiotic-resistant pathogenic bacteria by exerting selective pressure on spread of antibiotic-resistance genes.

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“…Each sample was run in triplicate along with an internal control (β-actin) using StepOnePlus real-time PCR system (Applied Biosystem, Foster City, CA, USA). The conditions (time and temperature) of thermal cycles and melting curves were performed as previously described [22,23]. The gene expression (in form of fold change) was determined by the 2 −∆∆Ct method.…”

Section: Real-time Pcrmentioning

confidence: 99%

Association of GHR Polymorphisms with Milk Production in Buffaloes

El-Komy

Saleh

Abdel-Hamid

et al. 2020

Animals

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For its role in the mediation of growth hormone (GH) galactopoietic effect, growth hormone receptor (GHR) was considered a functional candidate gene for milk performance in cattle. However, its genetic variation and potential effect have not been investigated in Egyptian buffaloes. This study aimed to screen GHR for polymorphisms and study their associations with milk traits in Egyptian buffaloes. Polymerase chain reaction, single-strand conformation polymorphism, and sequencing were used to identify mutations in 4 exons (E4–E6 and E8) of the GHR gene in 400 Egyptian buffaloes. No polymorphisms were found in E4, while 2 SNPs (c.380G>A/p.Arg127Lys and c.387C>T/p.Gly129) in E5, one silent mutation (c.435A>G/p.Pro145) in E6, and another missense mutation (c.836T>A/p.Phe279Tyr) in E8 were detected. The c.380G>A SNP in the extracellular domain was associated with milk yield, fat %, protein %, and 305-day milk, fat and protein yield, with higher levels in animals carrying the mutant A allele. The c.836T>A SNP in the transmembrane domain was associated with milk yield, fat %, protein %, and 305-day milk, fat and protein yield, with higher milk yield and lower fat %, protein %, fat and protein yield in the mutant A allele-animals. Interestingly, animals with the two mutant AA alleles produced higher milk yield, fat %, protein %, fat and protein yield, accompanied with upregulated expressions of GHR, GH, insulin-like growth factor 1 (IGF1), prolactin (PRL), prolactin receptor (PRLR), β-casein (encoded by CSN2 gene), and diacylglycerol acyltransferase-1 (DGAT1) genes and proteins in milk somatic cells. Therefore, selection of Egyptian buffaloes with mutant AA haplotypes for the novel c.380G>A SNP and the well-known c.836T>A SNP could improve milk yield and quality in buffaloes.

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Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus

Cited by 42 publications

References 32 publications

Effects of Oxytetracycline and Gentamicin Therapeutic Doses on Hematological, Biochemical and Hematopoietic Parameters in Cyprinus carpio Juveniles

Effects of Oxytetracycline and Gentamicin Therapeutic Doses on Hematological, Biochemical and Hematopoietic Parameters in Cyprinus carpio Juveniles

Antibacterials in Aquatic Environment and Their Toxicity to Fish

Association of GHR Polymorphisms with Milk Production in Buffaloes

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