Dietary polyunsaturated fatty acids mediate the inverse association of stearoyl-CoA desaturase activity with the risk of fatty liver in dyslipidaemic individuals

Amor, Antonio J.; Cofán, Montserrat; Mateo-Gállego, Rocío; Cenarro, Ana; Civeira, Fernando; Ortega, Emilio; Ros, Emilio; Sala‐Vila, Aleix

doi:10.1007/s00394-018-1691-4

Cited by 8 publications

(6 citation statements)

References 41 publications

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“…Conversely, the novelty brought by our study was that JRVO supplementation decreased TG, T‐Ch, VLDL‐Ch, and LDL‐Ch levels, confirming its hypolipidemic effect. Along, JRVO was found to be rich in polyunsaturated acids especially α‐linolenic acid, which plays a role in the prevention of primary dyslipidemia in individuals . This reinforces the notion that consumption of the JRVO prevents hypercholesterolemia.…”

Section: Discussionsupporting

confidence: 73%

“…Along, JRVO was found to be rich in polyunsaturated acids especially α-linolenic acid, which plays a role in the prevention of primary dyslipidemia in individuals. 51 This reinforces the notion that consumption of the JRVO prevents hypercholesterolemia. Likewise, JRVO supplementation not only lowered the T-Ch, TG, and LDL-Ch but also increased the HDL-cholesterol, which is known to play an important role in the transport of cholesterol from peripheral cells to the liver by a pathway termed "reverse cholesterol transport".…”

Section: Effects Of Vegetable Oil (Jrvo) On Hepatic Tissuessupporting

confidence: 73%

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Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats

Soussi

Feki

2018

Environmental Toxicology

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Environmental pollutants, particularly lead, pose a serious threat to human and animal health that causes disturbances of several functions, including hepatotoxicity. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. This study was carried out to investigate the protective efficacy of Juglans regia vegetable oil (JRVO) against the hepatotoxicity induced by lead. To achieve this aim, adults male rats were treated for 10 days with Pb (0.344 g/kg bw) associated or not with JRVO (0.9 g/kg bw). The rats intoxicated by lead exhibited oxidative stress determined by TBARS, protein carbonyls, liver tumor necrosis factor‐α (TNF‐α), caspase‐3, and antioxidant status: SOD, CAT, GPx, and GSH. Administration of lead increased the levels of plasma hepatic markers (AST, ALT, LDH) and bilirubin, the lipid profiles (total cholesterol, triglycerides, VLDL‐Ch, LDL‐Ch levels, TBARS, NOx, and PCO), the plasmatic lipase activity and the inflammatory markers, while the plasmatic ALP decreased. Coadministration of JRVO restored all the hepatic markers, the lipid profiles and the antioxidants to near‐normal values and lowered the plasmatic lipase activity as well as the elevated thiobarbituric acid reactive substances. Hepatic histological studies confirmed the beneficial role of JRVO through the amelioration of all biochemical parameters. Our results suggest that Juglans regia vegetable oil contains promising substances to counteract the lead intoxication and may be efficient in the prevention of hepatotoxicity complications.

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Section: Discussionsupporting

confidence: 73%

Section: Effects Of Vegetable Oil (Jrvo) On Hepatic Tissuessupporting

confidence: 73%

Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats

Soussi

Feki

2018

Environmental Toxicology

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“…Liver-specific Scd1-knock-out (SCD1-LKO) mice were resistant to such hepatic injury. In a recent cross-sectional clinical study, it has been shown that the serum SCD1 activity index is significantly related to the risk of non-alcoholic fatty liver disease in patients with primary dyslipidemia (35). Of course, while interpreting these data, it should be noted that the index of serum SCD1 activity is not solely determined by the liver.…”

Section: Scd1 Prevents Lipotoxicity and Controls Hepatic Lipogenesismentioning

confidence: 99%

The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis

Mohammadzadeh

Hosseini

Alihemmati

et al. 2019

jrenhep

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Stearoyl-coenzyme A desaturase 1 (SCD1) is a microsomal enzyme that controls fatty acid metabolism and is highly expressed in hepatocytes. SCD1 may play a key role in liver development and hepatic lipid homeostasis through promoting monounsaturated protein acylation and converting lipotoxic saturated fatty acids into monounsaturated fatty acids. Imbalanced activity of SCD1 has been implicated in fatty liver induction, inflammation and stress. In this review, the role of SCD1 in hepatic development, function and pathogenesis is discussed. Additionally, emerging novel therapeutic agents targeting SCD1 for the treatment of liver disorders are presented.

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“…Thus, the ratio of MUFA to SFA was elevated, consistent with the increased SCD1 expression level. The total MUFA may have been limited by increased levels of PUFA, which are known to inhibit MUFA synthesis and to reduce DNL [64].…”

Section: Discussionmentioning

confidence: 99%

Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

et al. 2020

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Background Orotic acid (OA) has been intensively utilized to induce fatty liver in rats. Although the capacity of OA to cause steatosis is species-specific, previous in vitro studies indicate that humans could also be susceptible to OA-induced fatty liver. The aim of the present study was to re-elucidate the potential of OA exposure to modulate the cellular mechanisms involved in both non-alcoholic fatty liver disease pathogenesis and cellular protection from lipid accumulation. In addition, alterations in detailed fatty acid (FA) profiles of cells and culture media were analyzed to assess the significance of lipid metabolism in these phenomena. Methods In our experiments, human hepatocellular carcinoma HepG2 cells were exposed to OA. Bacterial endotoxin, lipopolysaccharide (LPS), was used to mimic hepatic inflammation. The lipogenic and inflammatory effects of OA and/or LPS on cells were assessed by labeling cellular lipids with Nile red stain and by performing image quantifications. The expression levels of key enzymes involved in de novo lipogenesis (DNL) and of inflammatory markers related to the disease development were studied by qRT-PCR. FA profiles of cells and culture media were determined from total lipids with gas chromatography–mass spectrometry. Results Our data indicate that although OA possibly promotes the first stage of DNL, it does not cause a definite lipogenic transformation in HepG2 cells. Reduced proportions of 16:0, increased stearoyl-Coenzyme A desaturase 1 mRNA expression and relatively high proportions of 16:1n-7 suggest that active delta9-desaturation may limit lipogenesis and the accumulation of toxic 16:0. Inflammatory signaling could be reduced by the increased production of long-chain n-3 polyunsaturated FA (PUFA) and the active incorporation of certain FA, including 18:1n-9, into cells. In addition, increased proportions of 20:4n-6 and 22:6n-3, total PUFA and dimethyl acetal 18:0 suggest that OA exposure may cause increased secretion of lipoproteins and extracellular vesicles. Conclusions The present data suggest that, apart from the transcription-level events reported by previous studies, modifications of FA metabolism may also be involved in the prevention of OA-mediated steatosis. Increased delta9-desaturation and secretion of lipoproteins and extracellular vesicles could offer potential mechanisms for further studies to unravel how OA-treated cells alleviate lipidosis.

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Dietary polyunsaturated fatty acids mediate the inverse association of stearoyl-CoA desaturase activity with the risk of fatty liver in dyslipidaemic individuals

Abstract: Total PUFA, regardless of their origin, mediates the relationship between SCD1 activity and NAFLD. This provides a new insight in the protective effects of PUFA against NAFLD, heretofore mostly focussed on PUFA species from marine origin.

Cited by 8 publications

References 41 publications

Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats

Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead‐mediated hepatic damage and their interaction with lipase activity in rats

The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis

Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

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