Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Nirumand, Mina Cheraghi; Hajialyani, Marziyeh; Rahimi, Roja; Farzaei, Mohammad Hosein; Zingue, Stéphane; Nabavi, Seyed Mohammad; Bishayee, Anupam

doi:10.3390/ijms19030765

Cited by 147 publications

(98 citation statements)

References 109 publications

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“…Funamoto et al also reported that EGCG may have a renoprotective effect after cardiopulmonary bypass in diabetic rats (117). In related work, green tea supplementation prevented the growth of rat kidney-side crystals, decreased oxalate excretion, and had inhibitory effects on the activities of N-acetylβ-D glucosaminidase (118).…”

Section: Polyphenols Microbiota and Ckdmentioning

confidence: 95%

The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

2020

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Section: Polyphenols Microbiota and Ckdmentioning

confidence: 95%

The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

2020

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“…Most kidney calculi are composed of calcium; calcium oxalate stones are the most common, accounting for 74.8% of all cases of stones [3]. In response to increasing incidence of kidney calculi, various interventions have been performed to prevent the occurrence of stones, including dietary interventions and medical treatments [4][5][6]. Among them, thiazide diuretics are the commonly used drugs for preventing recurrent kidney calculi [7,8].…”

Section: Page 2 Of 12mentioning

confidence: 99%

Use of thiazide diuretics for the prevention of recurrent kidney calculi: a systematic review and meta-analysis

Gao

Liu

et al. 2020

J Transl Med

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Background: Thiazide diuretics reduce the risk of recurrent kidney calculi in patients with kidney calculi or hypercalciuria. However, whether thiazide diuretics can definitely prevent recurrent kidney calculi remains unclear. We aimed to evaluate the effect and safety of thiazide diuretics on recurrent kidney calculi. Methods:The PubMed, Cochrane Library, and EMBASE databases were systematically searched using the keywords thiazide diuretics and kidney calculi to identify randomized controlled trials (RCTs). The primary outcome was the incidence of recurrent kidney calculi, and the secondary outcome was the 24-h urinary calcium level. The pooled risk ratio (RR), risk difference (RD), standardized mean difference (SMD), and 95% confidence interval (CI) were calculated. The evidence quality was graded using the GRADE criteria, and recommendations for recurrent kidney calculus prevention using thiazide diuretics were reassessed.Results: Eight RCTs involving 571 patients were included. The pooled RR for the incidence of kidney calculi in the thiazide diuretic groups was 0.44 (95% CI 0.33-0.58, P < 0.0001) compared to that in the placebo and untreated groups; the pooled RD was − 0.23 (95% CI − 0.30 to − 0.16, P < 0.0001). The pooled SMD for the 24-h urinary calcium level was − 18.59 (95% CI − 25.11 to − 12.08, P < 0.0001). The thiazide diuretic groups had a high incidence of adverse reactions and low tolerance. The evidence quality for decrease in kidney calculus incidence using thiazide diuretics was low, while that for the 24-h urinary calcium level decrease among those with recurrent kidney calculi was moderate, and that for the decrease in kidney calculus incidence using short-acting and long-acting thiazide diuretics was low. The overall strength of recommendation for prevention of recurrent renal calculi using thiazide diuretics was not recommended. The subgroup and sensitivity analysis findings were robust. Conclusions:Long-term use of thiazide diuretics reduces the incidence of recurrent renal calculi and 24-h urinary calcium level. However, the benefits are insufficient, and the evidence quality is low. Considering the adverse effects, poor patient compliance, and economic burden of long-term medication, their use in preventing recurrent kidney calculi is not recommended.

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“…While in rat model of kidney stones, brushite supersaturation is significantly decreased [28], Bcl-2 expression is enhanced, superoxide dismutase (SOD) activity is increased, and the apoptotic index is decreased [30]. Hence by and large formation of calcium oxalate stones in the kidneys is impeded by the antioxidant rich green tea [8].…”

Section: Paronychia Argenteamentioning

confidence: 99%

“…Therefore, several alternative therapies for the treatment of kidney stones are being explored. Numerous medicinal plants have been chosen as an effective treatment of urolithiasis as they inhibit kidney stone formation at various steps because of their antispasmodic, antioxidant and diuretic activities [8]. A number of plant extracts have been found to exhibit antilithogenic properties as they decrease the calcium ion concentration or increase citrate and magnesium excretion by changing the ion composition of urine [1].The motive of the following work is to critically review available literature on herbal medicines and their possible role in the management of urolithiasis.…”

Section: Introductionmentioning

confidence: 99%

Phyto-molecules for Kidney Stones Treatment and Management

Gupta¹,

Kanwar²

2018

Biochem Anal Biochem

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It has been centuries since humans are being affected by kidney stones or urolithiasis. In the past decade, in rural and the urban sectors, kidney stone cases are rising at an alarming rate having a high relapse rate. The rate and prevalence of urolithiasis has been attributed to a number of factors such as age, fluid intake, infections of the urinary tract, climatic conditions sex, genetic predisposition, ethnicity as well as diet. Kidney stones may cause extreme pain and blockage of urine flow, urinary tract infection, hydronephrosis and severe bleeding which necessitates the use of surgery in some cases to remove or break the stones. Although a number of treatments for kidney stones are available which include extracorporeal shock wave lithotripsy (ESWL) and drug therapy but the expensive nature of these therapies and the severe side effects caused by exposure to these shock waves such as acute renal injury, decreased renal function and increased stone recurrence limit their use. As proposed by several in vivo and in vitro studies and clinical trials, using phyto-molecules in the treatment and management of kidney stones has emerged as a novel option. The following study discuses about the various plants, their chemical constituents involved along with their mechanism of action that can be used for the treatment of kidney stones.

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Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Cited by 147 publications

References 109 publications

The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

Use of thiazide diuretics for the prevention of recurrent kidney calculi: a systematic review and meta-analysis

Phyto-molecules for Kidney Stones Treatment and Management

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