Dietary Phytoecdysteroids

Dinan, Laurence; Mamadalieva, Nilufar Z.; Lafont, René

doi:10.1007/978-981-13-1745-3_35-1

Cited by 9 publications

(8 citation statements)

References 99 publications

(89 reference statements)

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“…Research in this area has a long history and started soon after the structural identification of ecdysone (E) and 20-hydroxyecdysone (20E) from arthropods and the discovery of analogues in plants in 1965 [ 5 ], when it was thought that the compounds might be useful invertebrate control agents. As a consequence, considerable effort was put into the total chemical synthesis of E and 20E (reviewed in [ 6 ]), determining the toxicity and initial pharmacokinetic studies in mammals.…”

Section: A Traditional Medicinal Productmentioning

confidence: 99%

20-Hydroxyecdysone, from Plant Extracts to Clinical Use: Therapeutic Potential for the Treatment of Neuromuscular, Cardio-Metabolic and Respiratory Diseases

et al. 2021

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There is growing interest in the pharmaceutical and medical applications of 20-hydroxyecdysone (20E), a polyhydroxylated steroid which naturally occurs in low but very significant amounts in invertebrates, where it has hormonal roles, and in certain plant species, where it is believed to contribute to the deterrence of invertebrate predators. Studies in vivo and in vitro have revealed beneficial effects in mammals: anabolic, hypolipidemic, anti-diabetic, anti-inflammatory, hepatoprotective, etc. The possible mode of action in mammals has been determined recently, with the main mechanism involving the activation of the Mas1 receptor, a key component of the renin–angiotensin system, which would explain many of the pleiotropic effects observed in the different animal models. Processes have been developed to produce large amounts of pharmaceutical grade 20E, and regulatory preclinical studies have assessed its lack of toxicity. The effects of 20E have been evaluated in early stage clinical trials in healthy volunteers and in patients for the treatment of neuromuscular, cardio-metabolic or respiratory diseases. The prospects and limitations of developing 20E as a drug are discussed, including the requirement for a better evaluation of its safety and pharmacological profile and for developing a production process compliant with pharmaceutical standards.

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Section: A Traditional Medicinal Productmentioning

confidence: 99%

20-Hydroxyecdysone, from Plant Extracts to Clinical Use: Therapeutic Potential for the Treatment of Neuromuscular, Cardio-Metabolic and Respiratory Diseases

et al. 2021

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“…Ecdysteroids have long been recognized for various potential beneficial effects on animal species and humans, including hypolipidemic, antidiabetic, hepatoprotective, adaptogenic as well as growth-promoting and anabolic effects. [12][13][14][15][16][17][18][19][20][21] In vivo and in vitro studies have shown that ecdysterone increases protein synthesis and muscle mass. [20,21] As reported in Parr et al, [21] this effect involves mediation by estrogen receptor beta (ER-𝛽).…”

Section: Introductionmentioning

confidence: 99%

Urinary Excretion of Ecdysterone and Its Metabolites Following Spinach Consumption

Yuliandra,

Touvleliou,

de la Torre

et al. 2023

Molecular Nutrition Food Res

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Scope:The phytosteroid ecdysterone is present in spinach. In this study, the urinary elimination of ecdysterone and its metabolites in humans is investigated following spinach consumption of two different culinary preparations. Methods and results: Eight participants (four males, four females) ingested 950 (27.1) g sautéed spinach (average [±standard deviation (SD)]) and 912 (70.6) g spinach smoothie as second intervention after washout. Post-administration urines are analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS). After intake of both preparations, ecdysterone and two metabolites, 14-deoxy-ecdysterone, and 14-deoxy-poststerone, are excreted in urine. The maximum concentration of ecdysterone is ranging from 0.09 to 0.41 µg mL −1 after sautéed spinach and 0.08-0.74 µg mL −1 after smoothie ingestion. The total excreted amount (mean% [±SD]) in the urine as a parent drug plus the metabolites is only 1.4 (1.0) for both sautéed spinach and smoothie. The apparent sex related differences in 14-deoxy-poststerone excretion will need further investigations. Conclusion: Only a small proportion of ecdysterone from spinach is excreted into urine. No significant differences are found in concentration and recovered amount (%) of ecdysterone, 14-deoxy-ecdysterone, and 14-deoxy-poststerone in urine between sautéed spinach and smoothie ingestion. A discrimination between ecdysterone from food or preparations will be challenging based on urinary concentrations only, at least for later post-administration samples.

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“…2a ). Es gibt mehr als 300 verschiedene Derivate davon 7 8 . Sie wurden zunächst aus dem Seidenspinner Bombyx mori isoliert und sind hier vor allem am Häutungsprozess (Ecdysis) beteiligt, wovon sich auch der Name ableitet 9 10 11 .…”

Section: Ecdysteroide Und Ecdysteronunclassified

Spinat und Ecdysteroide

Hermann

2023

Ernährung & Medizin

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Dietary Phytoecdysteroids

Cited by 9 publications

References 99 publications

20-Hydroxyecdysone, from Plant Extracts to Clinical Use: Therapeutic Potential for the Treatment of Neuromuscular, Cardio-Metabolic and Respiratory Diseases

20-Hydroxyecdysone, from Plant Extracts to Clinical Use: Therapeutic Potential for the Treatment of Neuromuscular, Cardio-Metabolic and Respiratory Diseases

Urinary Excretion of Ecdysterone and Its Metabolites Following Spinach Consumption

Spinat und Ecdysteroide

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