Dietary patterns and risk for Crohnʼs disease in children

D’Souza, Savio; Lévy, Émile; Mack, David R.; Israel, David M.; Lambrette, Philippe; Ghadirian, Parviz; Deslandres, Colette; Morgan, Kenneth; Seidman, Ernest G.; Amre, Devendra

doi:10.1002/ibd.20333

Cited by 127 publications

(111 citation statements)

References 30 publications

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“…The characteristics of the final nine studies selected for analysis are shown in Table 1 (15)(16)(17)(18)(19)(20)(21)(22)(23). Two cohort and seven case-control studies were included.…”

Section: Literature Review and Study Characteristicsmentioning

confidence: 99%

“…Four studies divided meat consumption into lowest intake, medium intake, and high intake (15,18,20,22); two studies defined high intake as meat consumption for >7 times/week, medium consumption as 3-5 times/week, and low consumption as <1 time/month (18,20). Two studies classified meat consumption into three groups by quartiles (T1-T3) of energy-adjusted intake among controls (19,23), and one study classified consumption into four groups by quartiles (Q1-Q4) (17). Among these studies, the confirmation of outcome was obtained from the cancer registry.…”

Section: Literature Review and Study Characteristicsmentioning

confidence: 99%

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Meat intake and risk of inflammatory bowel disease: A meta-analysis

Han²,

Liu³

et al. 2020

Turk J Gastroenterol

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Background/Aims: This meta-analysis is designed to determine the association between meat consumption and the risk of inflammatory bowel disease. Materials and Methods: Search relevant literature published in PubMed, Cochrane before July 2015 without restrictions. Studies were included if relative ratios and the corresponding 95% confidence intervals of the risk of inflammatory bowel disease were reported with respect to meat consumption. Results: Nine studies were included in this meta-analysis. Relative to those who did not or seldom eat meat, meat consumers had a significantly greater risk of inflammatory bowel disease (pooled relative ratio: 1.50, 95% confidence interval: 1.15-1.95). The funnel plot revealed no evidence for publication bias. Conclusion: Meat consumption may increase the risk of inflammatory bowel disease. Additional large prospective studies are warranted to verify this association.

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“…The characteristics of the final nine studies selected for analysis are shown in Table 1 (15)(16)(17)(18)(19)(20)(21)(22)(23). Two cohort and seven case-control studies were included.…”

Section: Literature Review and Study Characteristicsmentioning

confidence: 99%

Section: Literature Review and Study Characteristicsmentioning

confidence: 99%

Meat intake and risk of inflammatory bowel disease: A meta-analysis

Han²,

Liu³

et al. 2020

Turk J Gastroenterol

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“…To assess the impact of overall diet on the development of IBD, the correlations between groups of foods and nutrients that define different dietary patterns should be taken into account. 12 In several diseases, especially cancer [13][14][15][16][17][18] [20][21][22] Since no prospective studies are available in UC or CD, we conducted a study in a large European prospective cohort to examine the risk of developing UC and CD associated with adherence to Mediterranean diet score and with a posteriori dietary patterns produced by factor analysis.…”

mentioning

confidence: 99%

Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe

Racine

Carbonnel

Chan

et al. 2016

Inflammatory Bowel Diseases

226

159

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“…Recent accumulation of data suggests that certain components in the diet have critical roles in the physiological development of the gut immune system (2,(5)(6)(7). Malnutrition is known to result in a higher susceptibility to intestinal infections or autoimmune-mediated gut inflammation (2,(8)(9)(10).…”

mentioning

confidence: 99%

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

Kinoshita

Kayama

Kusu

et al. 2012

The Journal of Immunology

118

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Dietary compounds as well as commensal microbiota contribute to the generation of a unique gut environment. In this study, we report that dietary folic acid (FA) is required for the maintenance of Foxp3+ regulatory T cells (Tregs) in the colon. Deficiency of FA in the diet resulted in marked reduction of Foxp3+ Tregs selectively in the colon. Blockade of folate receptor 4 and treatment with methotrexate, which inhibits folate metabolic pathways, decreased colonic Foxp3+ Tregs. Compared with splenic Tregs, colonic Tregs were more activated to proliferate vigorously and were highly sensitive to apoptosis. In colonic Tregs derived from mice fed with a FA-deficient diet, expression of anti-apoptotic molecules Bcl-2 and Bcl-xL was severely decreased. A general reduction of peripheral Tregs was induced by a neutralizing Ab against IL-2, but a further decrease by additional FA deficiency was observed exclusively in the colon. Mice fed with an FA-deficient diet exhibited higher susceptibility to intestinal inflammation. These findings reveal the previously unappreciated role of dietary FA in promotion of survival of Foxp3+ Tregs that are in a highly activated state in the colon.

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Dietary patterns and risk for Crohnʼs disease in children

Abstract: Our results suggest that specific dietary patterns could be associated with higher or lower risks for CD in children. Larger prospective studies are required to confirm these findings.

Cited by 127 publications

References 30 publications

Meat intake and risk of inflammatory bowel disease: A meta-analysis

Meat intake and risk of inflammatory bowel disease: A meta-analysis

Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

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