Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

Kinoshita, Makoto; Kayama, Hisako; Kusu, Takashi; Yamaguchi, Tomoyuki; Kunisawa, Jun; Kiyono, Hiroshi; Sakaguchi, Shimon; Takeda, Kiyoshi

doi:10.4049/jimmunol.1200420

Cited by 118 publications

(94 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…tTregs constitutively express high level of folate receptor 4 (FR4), which binds FA and delivers FA derivatives into cells [36]. The importance of dietary FA to Tregs is revealed by the selective reduction of intestinal Tregs in mice fed with FA-deficient diet or treated with an inhibitor that disrupts FA metabolism [37]. FA promotes Treg cellularity by inhibiting apoptosis [37, 38].…”

Section: Host Metabolism and Tregsmentioning

confidence: 99%

“…The importance of dietary FA to Tregs is revealed by the selective reduction of intestinal Tregs in mice fed with FA-deficient diet or treated with an inhibitor that disrupts FA metabolism [37]. FA promotes Treg cellularity by inhibiting apoptosis [37, 38]. Further, FA deficiency leads to increased colonic inflammation, which can be ameliorated by transfer of FR4 + tTregs [37].…”

Section: Host Metabolism and Tregsmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic control of regulatory T cell development and function

Zeng

Chi

2015

Trends in Immunology

240

176

View full text Add to dashboard Cite

Foxp3+ regulatory T cells (Tregs) maintain immune tolerance and play an important role in immunological diseases and cancers. Recent studies have revealed an intricate relationship between Treg biology and host and microbial metabolism. Various metabolites or nutrients produced by host and commensal microbes, such as vitamins and short chain fatty acids (SCFAs), regulate Treg generation, trafficking and function. Furthermore, cell-intrinsic metabolic programs, orchestrated by mTOR and other metabolic sensors, modulate Foxp3 induction and Treg suppressive activity. Conversely, Tregs are crucial in regulating obesity-associated inflammation and host metabolic balance, and shaping homeostasis of gut microbiota. This review discusses the interplay between Tregs and metabolism, with a particular focus on how host, commensal and cellular metabolism impinges upon Treg homeostasis and function.

show abstract

Section: Host Metabolism and Tregsmentioning

confidence: 99%

Section: Host Metabolism and Tregsmentioning

confidence: 99%

Metabolic control of regulatory T cell development and function

Zeng

Chi

2015

Trends in Immunology

240

176

View full text Add to dashboard Cite

show abstract

“…Thus, we propose that folate supplementation might prevent median clefts by enhancing cell survival. Precedent for such a protective role of folate supplementation exists in the immune system and in cancer cells [91, 92]. Together, our results point toward an interaction where folate and retinoic acid converge on the regulation of facial prominence growth by altering apoptosis and cell division.…”

Section: Introductionmentioning

confidence: 73%

Using frogs faces to dissect the mechanisms underlying human orofacial defects

Dickinson

2016

Seminars in Cell & Developmental Biology

View full text Add to dashboard Cite

In this review I discuss how Xenopus laevis is an effective model to dissect the mechanisms underlying orofacial defects. This species has been particularly useful in studying the understudied structures of the developing face including the embryonic mouth and primary palate. The embryonic mouth is the first opening between the foregut and the environment and is critical for adult mouth development. The final step in embryonic mouth formation is the perforation of a thin layer of tissue covering the digestive tube called the buccopharyngeal membrane. When this tissue does not perforate in humans it can pose serious health risks for the fetus and child. The primary palate forms just dorsal to the embryonic mouth and in non-amniotes it functions as the roof of the adult mouth. Defects in the primary palate result in a median oral cleft that appears similar across the vertebrates. In humans, these median clefts are often severe and surgically difficult to repair. Xenopus has several qualities that make it advantageous for craniofacial research. The free living embryo has an easily accessible face and we have also developed several new tools to analyze the development of the region. Further, Xenopus is readily amenable to chemical screens allowing us to uncover novel gene-environment interactions during orofacial development, as well as to define underlying mechanisms governing such interactions. In conclusion, we are utilizing Xenopus in new and innovative ways to contribute to craniofacial research.

show abstract

“…An interesting point is that even in the presence of CD28 signaling, rapamycin-treated T CD4 + cells can become anergic. In summary, it can be concluded that mTOR plays a central role in the fate of T CD4 (Table I) (10,15,19,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). As shown in Table I, several studies have been devised to find the mechanisms involved in determining T CD4 + cells differentiations, and factors like fatty acids and vitamins have been evaluated.…”

Section: Resultsmentioning

confidence: 99%

Metabolism plays the key roles in Th cells differentiation

et al. 2016

View full text Add to dashboard Cite

The increasing rate of autoimmunity in recent decades cannot be related to only genetic instabilities and disorders. Diet can directly influence our health. Studies have shown that there is a relationship between nutritional elements and alteration in the immune system. Among immune cells, the function of T lymphocyte is important in directing immune response. T CD4+ cells lead other immune cells to respond to pathogens by secreting cytokines. HIV+ patients, who have largely lost their T CD4+ cells, are susceptible to opportunistic infections, which do not normally affect healthy people. It seems that the metabolism of T cells is critical for their differentiation and their consequent functions. After activation, T cells need to undergo clonal expansion, which is a high energy- consuming process. Studies have shown that specific metabolites deprivation or their excess supply affects T CD4+cells subsets differentiation. Abnormal induction of subsets of T CD4+ cells causes some autoimmunity reactions and hyper-sensitivity as well, which may result from imbalance of diet uptake. In this mini-review, we describe the findings about fatty acids, glucose, amino acids, and vitamins, which are effective in determining the fates of T CD4+ cells. These findings may help us uncover the role of diet in autoimmune diseases.

show abstract

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

Cited by 118 publications

References 45 publications

Metabolic control of regulatory T cell development and function

Metabolic control of regulatory T cell development and function

Using frogs faces to dissect the mechanisms underlying human orofacial defects

Metabolism plays the key roles in Th cells differentiation

Contact Info

Product

Resources

About