Dietary patterns and Helicobacter pylori infection in a group of Chinese adults ages between 45 and 59 years old

Abstract

Limited studies have reported the association between dietary patterns and the risk of Helicobacter pylori (H pylori) infection. The purpose of this study was to evaluate the relationship between dietary patterns and H pylori infection in a Chinese population ages from 45 to 59 years. We performed a cross-sectional examination of the associations between dietary patterns and H pylori infection in 3014 Chinese adults ages between 45 and 59 years from Hangzhou city, Zhejiang province, China. Dietary intake was assessed through a semi-quantitative food frequency questionnaire (FFQ). H pylori infection was diagnosed using the 13C-urea breath test. Multivariable logistic regression analyses were used to determine the associations between dietary patterns and the risk of H pylori infection. The prevalence of H pylori infection was 27.5%. Four major dietary patterns were identified by means of factor analysis: health-conscious, Western, grains-vegetables and high-salt patterns. After adjustment for the potential confounders, participants in the highest quartile of the “grains-vegetables” pattern scores had a lower odds ratio (OR) for H pylori infection (OR = 0.82; 95% confidence interval [CI]: 0.732–0.973; P = .04) than did those in the lowest quartile. Compared with those in the lowest quartile, participants in the highest quartile of the “high-salt” pattern scores had a greater OR for H pylori infection (OR = 1.13; 95%CI: 1.004–1.139; P = .048). Besides, no significant associations were found between the “health-conscious” and “Western” dietary patterns and the risk of H pylori infection.Our findings demonstrate that the “grains-vegetables” pattern is associated with a decreased risk, while “high-salt” pattern is associated with an increased risk of H pylori infection.

Review: Epidemiology of Helicobacter pylori infection

“…8 Altogether 24 471 adult subjects, aged 16 years or older (mean age 51.7 years), having visited a healthcare center or an outpatient medical clinic for a routine health examination during the study period, were enrolled and investigated by means of upper endoscopy and serology (anti-H pylori IgG); data on behavioral factors and previous medical history were collected by using a questionnaire. 10 In 3252 subjects without previous history of H pylori eradication, the prevalence of the infection was 27.5%. During the most recent years (2016-2017), 23% of the study population reported previous eradication therapy; this was higher than in subjects recruited within the previous periods (13.9% in 2005 and 19.3% in 2011).…”

“…9 A prevalence study on 45-and 59-year-old individuals residing in Zhejiang Province in East China and attending annual health examinations was performed in 2015-2016. 10 In 3252 subjects without previous history of H pylori eradication, the prevalence of the infection was 27.5%. However, the study participants were recruited in the capital of the province where the income and educational level are higher than in the general population; this could explain the lower H pylori prevalence rates compared to previously reported prevalence rates in China.…”

“…10 A seroprevalence study 12 using multiplex serology (a method for simultaneous detection of multiple H pylori antigens) was conducted in an observational cross-sectional cohort involving 2555 adult subjects from different regions of Spain (recruited from 2008 to 2013) who were recruited as the control population for a cancer risk stratification project (MCC-Spain) (study design available from (http://www.mccsp ain.org/prese ntati on/). 10 A seroprevalence study 12 using multiplex serology (a method for simultaneous detection of multiple H pylori antigens) was conducted in an observational cross-sectional cohort involving 2555 adult subjects from different regions of Spain (recruited from 2008 to 2013) who were recruited as the control population for a cancer risk stratification project (MCC-Spain) (study design available from (http://www.mccsp ain.org/prese ntati on/).…”

“…Grain-and vegetable-rich diets were associated with lower H pylori prevalence compared to salt-rich diets. 10 A seroprevalence study 12 using multiplex serology (a method for simultaneous detection of multiple H pylori antigens) was conducted in an observational cross-sectional cohort involving 2555 adult subjects from different regions of Spain (recruited from 2008 to 2013) who were recruited as the control population for a cancer risk stratification project (MCC-Spain) (study design available from (http://www.mccsp ain.org/prese ntati on/). A high seroprevalence was found (87.2%).…”

Association between dietary patterns and prediabetes risk in a middle-aged Chinese population

“…Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ), and expressed as metabolic equivalent hours per week(MET-h/week) [29]. Then, based on MET-h/week, three categories of physical activity were assigned, including light, moderate and heavy [30].Additional information including smoking habits (never, current, and former smokers), education level(primary school or below, middle and high school, junior college or above) was recorded with a structured questionnaire. Moreover, total energy intake was estimated through this semi-quantitative FFQ, and results were expressed in kilocalorie per day (kcal/day) and categorized according to quartile.…”