Dietary oxidized frying oil activates hepatic stellate cells and accelerates the severity of carbon tetrachloride- and thioacetamide-induced liver fibrosis in mice

Suk, Fat Moon; Hsu, Fang-Yu; Lee, Yi‐Chieh; Chen, Tzu-Lang; Chiu, Wan‐Chun; Liao, Yi Jen

doi:10.1016/j.jnutbio.2023.109267

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…Experimental evidence suggests that attenuation of excessive TGF-β1 signaling or blockade of its activity exerts antifibrotic effects . Activated HSCs also secreted TGF-β and were accompanied by the activation of the TGF-β receptor . Activation of HSCs is intricately linked with the TGF-β1/Smad signaling pathway, wherein reduction of TGF-β1-induced Smad2/3 phosphorylation impedes HSC activation. , The TGF-β1/Smad signaling pathway was regulated by peroxisome proliferator-activated receptor-gamma (PPAR-γ), which had protective effects on hepatic fibrosis .…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells

Sun,

Du,

Cao

et al. 2024

Mol. Pharmaceutics

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The capillarization of hepatic sinusoids resulting from the activation of hepatic stellate cells poses a significant challenge, impeding the effective delivery of therapeutic agents to the Disse space for liver fibrosis treatment. Therefore, overcoming these barriers and achieving efficient drug delivery to activated hepatic stellate cells (aHSCs) are pressing challenge. In this study, we developed a synergistic sequential drug delivery approach utilizing neutrophil membrane hybrid liposome@atorvastatin/amlisentan (NCM@AtAm) and vitamin A-neutrophil membrane hybrid liposome @ albumin (VNCM@Bai) nanoparticles (NPs) to breach the capillary barrier for targeted HSC cell delivery. Initially, NCM@AtAm NPs were successfully directed to the site of hepatic fibrosis through neutrophil-mediated inflammatory targeting, resulting in the normalization of liver sinusoidal endothelial cells (LSECs) and restoration of fenestrations under the combined influence of At and Am. Elevated tissue levels of the p-Akt protein and endothelial nitric oxide synthase (eNOS) indicated the normalization of LSECs following treatment with At and Am. Subsequently, VNCM@Bai NPs traversed the restored LSEC fenestrations to access the Disse space, facilitating the delivery of Bai into aHSCs under vitamin A guidance. Lastly, both in vitro and in vivo results demonstrated the efficacy of Bai in inhibiting HSC cell activation by modulating the PPAR γ/TGF-β1 and STAT1/ Smad7 signaling pathways, thereby effectively treating liver fibrosis. Overall, our designed synergistic sequential delivery system effectively overcomes the barrier imposed by LSECs, offering a promising therapeutic strategy for liver fibrosis treatment in clinical settings.

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Section: Introductionmentioning

confidence: 99%

Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells

Sun,

Du,

Cao

et al. 2024

Mol. Pharmaceutics

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“…Cooking exposes palm oil to heat, which causes it to enter the body in an oxidized form. High-temperature (180°C) oil releases products known as oxygen derivatives and free radicals, which harm bodily tissues and can lead to the development of brosis in the liver tissue [7]. Hot oil is a common item in the food industry and is used daily by families and food vendors [8].…”

mentioning

confidence: 99%

Histopathological manifestations of liver tissue affected by heated and unheated palm oil in Wistar rats

Ahookhash,

Moradi,

ZHaleh

2024

Preprint

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Palm oil is the most widely used type of oil in the world, which is oxidized by exposure to heat and leads to damage to body tissues and the creation of free fatty acids. This study aimed to show the harm of palm oil in both heated and non-heated states. For this purpose, twenty-four male Wistar rats were randomly divided into three groups and treated as follows: control (rats treated with their normal chew), palm oil (rats treated with 7.5% w/w of palm oil added to their normal chew), and heated palm oil (rats treated with 7.5% w/w of palm oil into their normal chew, which had been heated repeatedly 10 times at 180°C for 10 min). After experimental treatments, the animals were euthanized. Liver samples were collected for histopathological assessment by hematoxylin and eosin (H&E) staining. In the groups treated with heated and unheated palm oil, signs of non-alcoholic fatty liver disease were observed at different proportions. Histological evidence is an indication that heated and unheated palm oils can cause various degrees of non-alcoholic fatty liver disease. Therefore, the consumption of palm oil, especially when heated, may not be completely safe.

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A characterized ethanol extract of Rosa rugosa inhibits hepatic stellate cell activation through elevating Hint1 and subsequent upregulation of Smad7

Gao

Liu

Lei

et al. 2023

Journal of Functional Foods

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Dietary oxidized frying oil activates hepatic stellate cells and accelerates the severity of carbon tetrachloride- and thioacetamide-induced liver fibrosis in mice

Cited by 4 publications

References 47 publications

Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells

Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells

Histopathological manifestations of liver tissue affected by heated and unheated palm oil in Wistar rats

A characterized ethanol extract of Rosa rugosa inhibits hepatic stellate cell activation through elevating Hint1 and subsequent upregulation of Smad7

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