Dietary obesity in nine inbred mouse strains

West, David B.; Boozer, Carol N.; Moody, Dorothy L.; Atkinson, Robert K.

doi:10.1152/ajpregu.1992.262.6.r1025

Cited by 353 publications

(393 citation statements)

References 15 publications

(3 reference statements)

Supporting

Mentioning

344

Contrasting

Unclassified

Order By: Relevance

“…The evaluation of genotype by environment interactions is important in understanding the complex and multifactorial nature of obesity. Significant interaction between genotype and dietary environment has been described where males representing six inbred mouse strains experienced a significant increase in carcass lipid content when fed a high-fat diet, while three other strains were resistant to the high-fat diet (West et al, 1992). In the present study, the most notable effect of the HIGH diet was an increase in body fat percentage in BL mice, similar to that previously reported (West et al, 1992).…”

Section: Discussionsupporting

confidence: 90%

“…Significant interaction between genotype and dietary environment has been described where males representing six inbred mouse strains experienced a significant increase in carcass lipid content when fed a high-fat diet, while three other strains were resistant to the high-fat diet (West et al, 1992). In the present study, the most notable effect of the HIGH diet was an increase in body fat percentage in BL mice, similar to that previously reported (West et al, 1992). When fed STN diet, MH and BL mice had different adjusted HLOSS and energy intake but a similar fat percentage.…”

Section: Discussionmentioning

confidence: 99%

“…Diet, as well as other environmental effects, is known to contribute to human obesity (Bouchard, 1994). In mice, high-fat diets have been shown to lead to obesity, increased weight gain per unit of feed consumed, and changes in plasma total cholesterol and triacylglyceride values (West et al, 1992 ;Kirk et al, 1995). However, responsiveness to high-fat diets varied among inbred mouse lines, indicating significant line by diet interaction effects (West et al, 1992 ;Kirk et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…In mice, high-fat diets have been shown to lead to obesity, increased weight gain per unit of feed consumed, and changes in plasma total cholesterol and triacylglyceride values (West et al, 1992 ;Kirk et al, 1995). However, responsiveness to high-fat diets varied among inbred mouse lines, indicating significant line by diet interaction effects (West et al, 1992 ;Kirk et al, 1995). Evaluation of the effect of differing dietary fat levels on HLOSS and body composition may reveal additional line by diet interactions important to understanding the relationships among diet, energy intake and expenditure, and obesity.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Variability in metabolic rate, feed intake and fatness among selection and inbred lines of mice

1997

View full text Add to dashboard Cite

SummaryMouse populations differing in metabolic rate have been developed through selection for high (MH) and low (ML) heat loss (HLOSS), along with randomly selected controls (MC). Objectives of this study were to (a) compare MH, ML and MC lines for HLOSS and correlated traits of feed intake, body composition and organ weights ; (b) compare three widely used inbred mouse lines with MH, ML and MC for the same traits ; and (c) investigate potential genotype by diet interaction resulting from feeding diets differing in fat percentage. Heat loss (kcal\day) of MH and ML mice differed by 37 % of the mean and remained significant (33 %) when HLOSS was expressed on a fat-free mass basis. MH mice consumed more energy than ML with a greater difference in mice fed high-fat compared with standard diets (27 % vs 13n9 %). Despite greater energy consumption, MH mice were leaner than ML with a difference in total body fat percentage of 40 %. The greatest difference in HLOSS between selection and inbred lines was between MH and C57BL\6J (BL), which differed by 26n3 %. MH and BL mice also differed in energy intake (15n5 %). Body composition of BL mice was similar to MH when fed a standard diet, but similar to ML when fed a high-fat diet. Crosses between MH and ML or between MH and BL would be useful to investigate the genetic regulation of, and identify quantitative trait loci influencing HLOSS, energy intake and body composition. Feeding of a high-fat diet may allow diet-specific loci influencing body composition to be identified in MH and BL lines.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Variability in metabolic rate, feed intake and fatness among selection and inbred lines of mice

1997

View full text Add to dashboard Cite

show abstract

“…Both diets were custom-prepared (Teklad Corporation, Madison, WI, USA; TD.85 080: LFCC diet, TD.83 402: HFS diet; Table 1) and were selected based on prior research (19,20,21) . Diets were designed to differ in energy density in order to address differences in bone mechanical properties between a high-energy-dense diet (HFS) and a lowenergy-dense diet (LFCC).…”

Section: Dietary Regimenmentioning

confidence: 99%

High-fat, sucrose diet impairs geometrical and mechanical properties of cortical bone in mice

et al. 2009

View full text Add to dashboard Cite

Exposure to diets high in fat and sucrose can induce hyperinsulinaemia, affect Ca and Mg metabolism, and alter bone mineralisation and mechanical properties. The present study assessed morphological and mechanical changes in a murine model exposed to a high-fat/sucrose (HFS) diet, as well as corresponding molecular and endocrine markers of bone turnover. Female C57BL/6 mice (aged 9 weeks) consumed either a low-fat, complex carbohydrate diet or an HFS diet for 10 weeks. At the end of the 10 weeks, serum was collected for biochemical analysis. Tibiae from half the mice (n 15) were randomly selected to be micro-computed tomography scanned and tested to failure in cantilever bending, while the remaining half were prepared for real-time PCR analysis. Serum tartrate-resistant acid phosphatase was significantly elevated in HFS mice, while osteocalcin remained unchanged. Both body mass and percentage body fat were greater in mice fed HFS diet. After adjusting for body mass, tibial structural and morphological properties were adversely affected in the HFS cohort. Cortical thickness, cross-sectional area, and load at maximum were all significantly lower in mice fed HFS diet. Receptor activator of nuclear factor kb ligand (RANKL) mRNA was significantly upregulated in HFS mice, but osteoprotegerin/RANKL mRNA ratio remained unchanged between cohorts. Moreover, cyclo-oxygenase-2 mRNA tended to be increased in HFS. Thus, ingestion of an HFS diet had a significant adverse effect on mouse bone morphology and mechanics, and these effects were likely due to elevated osteoclast activity associated with the inflammatory state of obesity, and not necessarily osteoclast recruitment/ proliferation.Cortical bone: High-fat/sucrose diet: Biomechanics: C57BL/6 mice The changing face of disease aetiology over the past century has brought to the forefront the need to examine the environmental or modifiable risk factors that have influenced the epidemic of chronic disease afflicting a majority of the Western world. Nutritional status is a readily modifiable risk factor linked to numerous chronic conditions, including CHD, cancer, obesity, diabetes and osteoporosis (1,2) . Nonetheless, despite the prevalence of research linking poor dietary choices to chronic disease status, the nutritional patterns presently dominating most Western nations continue to be high in saturated fats, Na and refined carbohydrates from sugars, cereals and dairy products, and low in fruits, vegetables and lean protein (3) .Considerable effort has focused on discovering the underlying nutritional factors that predispose an individual to osteopenia or osteoporosis and subsequent fracture (4) . Much research has concentrated on the role of Ca and vitamin D metabolites influencing bone morphology and mechanics; however, macronutrients such as fat, protein and carbohydrate also play a vital role in bone health (5) . Considered independently, consumption of diets composed of large amounts of saturated fat has been documented to cause the formation of insoluble soap complexe...

show abstract

Fat in the Diet and Obesity

Heitmann¹,

Lissner²

2001

International Textbook of Obesity

View full text Add to dashboard Cite

During recent decades, trends of declining fat intake have been reported for most countries. However, both diet surveys and food disappearance data suggest that for most countries, fat intake is still above the recommended 30% of total energy. Countries like the USA and Norway have reported particular success in reduction of dietary fat intake (1,2). In the USA, for instance, a reduction in energy from fat from about 40% to 33% was achieved between 1960 and 1995 (1). In Norway, fat intake was reduced from 40% to 34% in only 15 years (2), making Norwegians a role model for the other Nordic countries, where a high fat consumption is the tradition. Finland (3) has followed this trend, and now reports patterns of decreasing fat intake similar to those in the USA and Norway. However, some countries, like Denmark and Sweden, still displayed intake figures for fat consumption as high as 39-43% until the late 1980s, and only recently have decreases been reported (4-6).

show abstract

Dietary obesity in nine inbred mouse strains

Cited by 353 publications

References 15 publications

Variability in metabolic rate, feed intake and fatness among selection and inbred lines of mice

Variability in metabolic rate, feed intake and fatness among selection and inbred lines of mice

High-fat, sucrose diet impairs geometrical and mechanical properties of cortical bone in mice

Fat in the Diet and Obesity

Contact Info

Product

Resources

About