Dietary nutrition for neurological disease therapy: Current status and future directions

Mao, Xiao‐Yuan; Yin, Xi-Xi; Guan, Qi-Wen; Xia, Qin-Xuan; Yang, Nan; Zhou, Hong‐Hao; Liu, Zhao‐Qian; Jin, Weilin

doi:10.1016/j.pharmthera.2021.107861

Cited by 44 publications

(29 citation statements)

References 281 publications

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“…Neurodegeneration is the progressive loss of structure or function of neurons, which could lead to their death. New research suggests that dietary nutrition helps prevent and cure neurological symptoms in a variety of conditions [ 37 ]. Recently, interdisciplinary research in neurology and immunology has established a link between overeating and inflammation in the brain, and in particular, the hypothalamus [ 38 ].…”

Section: Cd47 Sirp and Neurodegenerationmentioning

confidence: 99%

CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways

et al. 2021

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CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesion, proliferation, apoptosis, migration, homeostasis, and the immune system. In this aspect, previous research has shown that CD47 modulates phagocytosis via macrophages, the transmigration of neutrophils, and the activation of T-cells, dendritic cells, and B-cells. Moreover, several studies have reported the increased expression of the CD47 receptor in a variety of diseases, including acute lymphoblastic leukemia (ALL), chronic myeloid leukemia, non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), bladder cancer, acute myeloid leukemia (AML), Gaucher disease, Multiple Sclerosis and stroke among others. The ubiquitous expression of the CD47 cell receptor on most resident cells of the CNS has previously been established through different methodologies. However, there is little information concerning its precise functions in the development of different neurodegenerative pathologies in the CNS. Consequently, further research pertaining to the specific functions and roles of CD47 and SIRP is required prior to its exploitation as a druggable approach for the targeting of various neurodegenerative diseases that affect the human population. The present review attempts to summarize the role of both CD47 and SIRP and their therapeutic potential in neurodegenerative disorders.

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Section: Cd47 Sirp and Neurodegenerationmentioning

confidence: 99%

CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways

et al. 2021

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“…Ferroptosis has a core role in many diseases, e.g., ischemic organ injury, cancer, as well as neurodegeneration (Stockwell et al, 2017). Abnormal activation of neuronal ferroptosis is an important pathogenesis of neurological diseases, and diet that affects ferroptosis can be an adjuvant therapy for these diseases (Mao et al, 2021). Recently, the stimulation of ferroptosis has mushroomed as an alternative therapeutic approach to tumor suppression, especially for therapy-resistant patients (Hassannia et al, 2019;Liang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

A Ferroptosis-Related Gene Model Predicts Prognosis and Immune Microenvironment for Cutaneous Melanoma

Chen

2021

Front. Genet.

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BackgroundCutaneous melanoma is a common but aggressive tumor. Ferroptosis is a recently discovered cell death with important roles in tumor biology. Nevertheless, the prognostic power of ferroptosis-linked genes remained unclear in cutaneous melanoma.MethodsCutaneous melanoma patients of TCGA (The Cancer Genome Atlas) were taken as the training cohort while GSE65904 and GSE22153 as the validation cohorts. Multifactor Cox regression model was used to build a prognostic model, and the performance of the model was assessed. Functional enrichment and immune infiltration analysis were used to clarify the mechanisms.ResultsA five ferroptosis-linked gene predictive model was developed. ALOX5 and GCH1 were illustrated as independent predictive factors. Functional assessment showed enriched immune-linked cascades. Immune infiltrating analysis exhibited the distinct immune microenvironment.ConclusionHerein, a novel ferroptosis-related gene prognostic model was built in cutaneous melanoma. This model could be used for prognostic prediction, and maybe helpful for the targeted and immunotherapies.

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“…Nowadays, the protein hydrolysates represent a good strategy to enhance the health of animals; indeed, the diet administration in animals model has been accepted as a useful approach to promote the formation of highly antioxidant peptides to contrast oxidative stress [ 13 ]. Many studies have also shown that neurodegenerative diseases could be prevented by changing the daily diet through its effect on the microbiota–gut-brain [ 14 , 15 , 16 ]. This will further contrast oxidative stress in the body of animals or human, and dietary composition is important for the structure and balance of gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Tilapia Head Protein Hydrolysate Attenuates Scopolamine-Induced Cognitive Impairment through the Gut-Brain Axis in Mice

Zhu

et al. 2021

Foods

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The destruction of the homeostasis in the gut-brain axis can lead to cognitive impairment and memory decline. Dietary intervention with bioactive peptides from aquatic products is an innovative strategy to prevent cognitive deficits. The present study aimed to determine the neuroprotective effect of tilapia head protein hydrolysate (THPH) on scopolamine-induced cognitive impairment in mice, and to further explore its mechanism through the microbiota–gut-brain axis. The results showed that THPH administration significantly improved the cognitive behavior of mice, and normalized the cholinergic system and oxidative stress system of the mice brain. The histopathological observation showed that THPH administration significantly reduced the pathological damage of hippocampal neurons, increased the number of mature neurons marked by NeuN and delayed the activation of astrocytes in the hippocampus of mice. In addition, THPH administration maintained the stability of cholinergic system, alleviated oxidative stress and further improved the cognitive impairment by reshaping the gut microbiota structure of scopolamine-induced mice and alleviating the disorder of lipid metabolism and amino acid metabolism in serum. In conclusion, our research shows that THPH supplementation is a nutritional strategy to alleviate cognitive impairment through the gut-brain axis.

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Dietary nutrition for neurological disease therapy: Current status and future directions

Cited by 44 publications

References 281 publications

CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways

CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways

A Ferroptosis-Related Gene Model Predicts Prognosis and Immune Microenvironment for Cutaneous Melanoma

Tilapia Head Protein Hydrolysate Attenuates Scopolamine-Induced Cognitive Impairment through the Gut-Brain Axis in Mice

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