Dietary Monoterpenoids

Asakawa, Yoshinori

doi:10.1007/978-981-13-1745-3_17-2

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…In the present study, GC-MS analysis revealed the presence of monoterpenoids p-menth-1-en-9-ol and 1,8-cineole as the dominant compounds in the hydrosol (Table 1). Oxygenated monoterpenes have been previously described as compounds with anticancer activity [59]. Moteki et al [60] reported the cytotoxic activity of 1,8-cineole in leukemia cancer cells.…”

Section: Antiproliferative Activitymentioning

confidence: 99%

Not Only a Weed Plant—Biological Activities of Essential Oil and Hydrosol of Dittrichia viscosa (L.) Greuter

Vuko

Dunkić

Maravić

et al. 2021

Plants

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With the increasing interest in obtaining biologically active compounds from natural sources, Dittrichia viscosa (L.) Greuter (Asteraceae) came into our focus as a readily available and aromatic wild shrub widely distributed in the Mediterranean region. This work provides a phytochemical profile of D. viscosa in terms of parallel chemical composition in the lipophilic fraction (essential oil) and the water fraction (hydrosol). GC-MS analysis identified 1,8-cineole, caryophyllene oxide, α-terpenyl acetate, and α-muurolol as the major components of the essential oil, while in the hydrosol p-menth-1-en-9-ol, 1,8-cineole, linalool, cis-sabinene hydrate, and α-muurolol were the major volatile components. 3,4-Dihydroxybenzoic acid was found to be the predominant compound in the hydrosol composition by HPLC analysis. The antimicrobial potential of both extracts was evaluated against thirteen opportunistic pathogens associated with common skin and wound infections and emerging food spoilage microorganisms. The antimicrobial activity of the essential oil suggests that the volatiles of D. viscosa could be used as novel antimicrobial agents. The antiproliferative results of D. viscosa volatiles are also new findings, which showed promising activity against three cancer cell lines: HeLa (cervical cancer cell line), HCT116 (human colon cancer cell line), and U2OS (human osteosarcoma cell line). The decrease in GSH level observed in hydrosol-treated HeLa cells suggests oxidative stress as a possible mechanism of the antiproliferative effect of hydrosol on tumor cells. The presented results are also the first report of significant antiphytoviral activity of hydrosol against tobacco mosaic virus (TMV) infection. Based on the results, D. viscosa might have the potential to be used in crop protection, as a natural disinfectant and natural anticancer agent.

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Section: Antiproliferative Activitymentioning

confidence: 99%

Not Only a Weed Plant—Biological Activities of Essential Oil and Hydrosol of Dittrichia viscosa (L.) Greuter

Vuko

Dunkić

Maravić

et al. 2021

Plants

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“…Several Nepeta species have traditionally been used as diuretic, diaphoretic, antitussive, antibacterial, antifungal, antispasmodic, antiasthmatic, febrifuge, sedative, spice and herbal tea, as well as food and food supplements, an ingredient of vegetable soup, traditional foods, and used for colds, flu, and bronchitis. Nepetalactones are characteristic monoterpenes for some Napeta species as discussed in the dietary monoterpenoids (Asakawa 2021); however, a number of this species produced different diterpenoids, mainly abietanes and pimaranes (Yilmaz et al 2016).…”

Section: Nepeta (Lamiaceae)mentioning

confidence: 99%

“…Each crude extract including some diterpenes possesses a number of different biological and pharmacological activities. The most frequently recognized activities of diterpenoids are antimicrobial, antifungal, anti-inflammatory, antioxidant, and cytotoxic effects as seen in monoterpenoids (Asakawa 2021).…”

Section: Biological and Pharmacological Activity Of Dietary Diterpenoids And Their Related Compoundsmentioning

confidence: 99%

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Dietary Diterpenoids

Asakawa

Kenmoku

2021

Handbook of Dietary Phytochemicals

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A number of foods, vegetables, fruits, and beverages (tea, coffee, and liqueur) contain many kinds of diterpenoids (mainly abietanes, cembranes, clerodanes, cyatanes, dolabellanes, fusicoccanes, kauranes, labdanes, pimaranes, taxanes, trachilobanes, totaranes) and their related compounds. This chapter summarizes the distribution of diterpenoids in dietary foods, vegetables, fruits, beverages, and processed foods, and their biological and pharmacological activity, effects, and application to our health, as well as metabolic pathways of several diterpenoids, which are widely distributed in dietary foods, by microorganisms and mammals.

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