Dietary magnesium, lung function, wheezing, and airway hyper-reactivity in a random adult population sample

The Epithelial Mg2+ Channel Transient Receptor Potential Melastatin 6 Is Regulated by Dietary Mg2+ Content and Estrogens

“…The exact function of TRPM6 in this organ, however, remains to be elucidated. The importance of Mg 2ϩ in lung is supported by the fact that dietary Mg 2ϩ intake is related directly to lung function, airway reactivity, and respiratory symptoms in the general population (53). Moreover, treatment of patients who have chronic asthma is currently receiving attention because of a role for Mg 2ϩ in relaxation of arterial and bronchial smooth muscle cells (54 -56).…”

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

“…Data for the study were taken from participants in a crosssectional survey of diet and lung disease that has been described previously (Britton et al, 1994b(Britton et al, , 1995. Briefly, participants were identified by systematic sampling from the electoral register of a Local Authority Area in Nottingham, and those aged 18-70 y on 1st January 1991 were invited to attend a local General Practice surgery or health centre for a questionnaire assessment and lung function tests.…”

Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema

“…Therefore, the current authors postulated that a high foetal exposure to the antioxidant trace elements (selenium, zinc, copper and manganese) might decrease the risk of wheezing and eczema in early childhood, and that high foetal exposure to lead and mercury might increase the risk of these conditions. The present authors speculated that a low foetal exposure to iron might play a role in aetiology, as this causes impaired foetal growth in animals [14], and that a low foetal exposure to magnesium might be a risk factor for wheezing, in view of an association later in life between dietary intake and bronchial hyperresponsiveness (BHR) [15].…”