“…The central role of CB1R in appetite, energy intake, energy conservation, and diet-induced obesity (Freitas et al, 2017, Mazier et al, 2015, Alvheim et al, 2014, Engeli et al, 2005, Engeli, 2008, Cota et al, 2003a, Cota et al, 2003b, Cardinal et al, 2012, DiPatrizio and Piomelli, 2012, Matias and Di Marzo, 2007, Matias et al, 2008, Pagotto et al, 2006, and the hyperphagia and hypothermia resulting from acute stimulation of CB1R by THC (Farrimond et al, 2011, Borgen et al, 1973, makes CB1R a prime suspect for a causative role in the effects of Cannabis use on BMI.…”