Dietary Lactobacillus acidophilus and Mannan-Oligosaccharides Alter the Lipid Metabolism and Health Indices in Broiler Chickens

Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides

“…The major organ of intermediary metabolism of lipids in broiler chicken is liver 1 , 2 . A balance between lipogenesis and lipolysis determines the rate of lipid deposition in broiler chicken 3 , 4 . A coordinated action of a series of genes involved in lipogenesis, lipolysis, transport, and deposition of lipids, such as acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), sterol regulatory element binding protein-1c (SREBP-1c), malic enzyme (ME), stearoyl CoA (Δ9) desaturase 1 (SCD-1), peroxisome proliferator activated receptor-α (PPAR-α), AMP-activated protein kinase (AMPK), and apolipoprotein B100 (apoB100) result in a net fat accretion in the body of broiler chicken 3 , 5 , 6 .…”

“…A balance between lipogenesis and lipolysis determines the rate of lipid deposition in broiler chicken 3 , 4 . A coordinated action of a series of genes involved in lipogenesis, lipolysis, transport, and deposition of lipids, such as acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), sterol regulatory element binding protein-1c (SREBP-1c), malic enzyme (ME), stearoyl CoA (Δ9) desaturase 1 (SCD-1), peroxisome proliferator activated receptor-α (PPAR-α), AMP-activated protein kinase (AMPK), and apolipoprotein B100 (apoB100) result in a net fat accretion in the body of broiler chicken 3 , 5 , 6 . Furthermore, the development of adipose in broiler chicken is determined by the serum triglyceride levels and the major substrates of lipid metabolism are triglycerides along with cholesterol fractions 6 .…”

“…Furthermore, the development of adipose in broiler chicken is determined by the serum triglyceride levels and the major substrates of lipid metabolism are triglycerides along with cholesterol fractions 6 . All these genes involved in lipogenesis, lipolysis, and transport of lipids are responsive to nutritional interventions directly or indirectly which results in alteration of lipid metabolism and the consequent lipid deposition in chicken 3 , 6 , 7 .…”

“…One of the prominent nutritional interventions in broiler chicken is the supplementation of dietary prebiotics and probiotics for desired growth, immunity, and meat quality of birds 8 , 9 ; and recent studies have focussed on the importance of prebiotics and probiotics in the regulation of lipid metabolism in broiler chicken 3 , 10 – 12 . The supplementation of prebiotics in broiler chicken foster the population of lactic acid producing bacteria of Bifidobacterium and Lactobacillus genera 4 , 13 .…”

“…Furthermore, modern broiler chicken strains are hyperphagic in nature and tend to deposit more fat in body 3 . But, the excess fat deposition in chicken is a double facet problem—firstly, it is an economic burden on poultry producers which is discarded while processingand causes waste management problems, secondly, it is highly associated with cardiovascular diseases in humans 17 , 18 .…”