Dietary iron and vitamins in association with mortality

Wang, Wenjie; Gao, Jian; Li, Na; Han, Shan; Wu, Lei; Zhang, Yunlong; Han, Tianshu; Shan, Ruiqi; Li, Ying; Sun, Changhao; Wu, Xiaoyan

doi:10.1016/j.clnu.2020.10.038

Cited by 15 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the cumulative effect of vitamins and iron exerts a protective role in decreasing all-cause mortality and cardiovascular diseases. This effect is observed in relation to higher dietary iron intake [57].…”

Section: Iron and Zinc Contentmentioning

confidence: 84%

Evaluation of Physicochemical Properties of Beetroot-Based Dietary Supplements

Brzezińska

Szewczyk

Brzezicha

et al. 2021

Foods

View full text Add to dashboard Cite

In the European Union, no specific requirements for the physicochemical parameters of dietary supplements have been established, contrary to the United States of America. This research aimed to assess the selected physical parameters of 31 commercially available beetroot-based dietary supplements in the form of tablets and capsules following the United States Pharmacopoeia (USP) guidelines and the Food and Drug Administration (FDA) recommendations. There was also estimated zinc and iron content by atomic absorption spectroscopy with flame detection. Results showed that nine products did not meet the USP requirements. Seven supplements needed more than 30 min to disintegrate. Two products in the form of tablets did not pass the friability test because of cracking. The hardness values varied significantly between manufacturers, demonstrating values from 59.1 to 455.8 N. The iron-enriched supplements differed significantly in iron content compared with the manufacturers’ declaration (84.91–140.69%). Inappropriate quality of dietary supplements, which may constitute a potential risk to consumers, can be related to the lack of specific regulations in Europe; hence, similar to the USA requirements should be considered in the European Union. The work emphasizes the need to better control the quality of dietary supplements before they are introduced to the European market.

show abstract

Section: Iron and Zinc Contentmentioning

confidence: 84%

Evaluation of Physicochemical Properties of Beetroot-Based Dietary Supplements

Brzezińska

Szewczyk

Brzezicha

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…Besides, BM-MSC, AT-MSCs could be an interesting source of MSCs, considering their proangiogenic properties, high resistance to hypoxia, and ease of isolation (Wang et al, 2020). The AT-MSC/BM-EPC combination increases osteogenesis and angiogenesis-related gene expression in vitro.…”

Section: Sources Of Mscs In Coculturementioning

confidence: 99%

“…The newly formed tissue was denser, and the vascular lumen structures were more mature. Intramembranous and enchondral ossification processes coexist (Wang et al, 2020). Hayrapetyan et al (2016) noticed that ECs showed a positive effect on osteogenic differentiation and mineralization in both direct and indirect culture systems in AT-MSC/HUVEC coculture.…”

Section: Sources Of Mscs In Coculturementioning

confidence: 99%

Cross-Talk Between Mesenchymal Stromal Cells (MSCs) and Endothelial Progenitor Cells (EPCs) in Bone Regeneration

Bouland

Philippart

Dequanter

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Bone regeneration is a complex, well-orchestrated process based on the interactions between osteogenesis and angiogenesis, observed in both physiological and pathological situations. However, specific conditions (e.g., bone regeneration in large quantity, immunocompromised regenerative process) require additional support. Tissue engineering offers novel strategies. Bone regeneration requires a cell source, a matrix, growth factors and mechanical stimulation. Regenerative cells, endowed with proliferation and differentiation capacities, aim to recover, maintain, and improve bone functions. Vascularization is mandatory for bone formation, skeletal development, and different osseointegration processes. The latter delivers nutrients, growth factors, oxygen, minerals, etc. The development of mesenchymal stromal cells (MSCs) and endothelial progenitor cells (EPCs) cocultures has shown synergy between the two cell populations. The phenomena of osteogenesis and angiogenesis are intimately intertwined. Thus, cells of the endothelial line indirectly foster osteogenesis, and conversely, MSCs promote angiogenesis through different interaction mechanisms. In addition, various studies have highlighted the importance of the microenvironment via the release of extracellular vesicles (EVs). These EVs stimulate bone regeneration and angiogenesis. In this review, we describe (1) the phenomenon of bone regeneration by different sources of MSCs. We assess (2) the input of EPCs in coculture in bone regeneration and describe their contribution to the osteogenic potential of MSCs. We discuss (3) the interaction mechanisms between MSCs and EPCs in the context of osteogenesis: direct or indirect contact, production of growth factors, and the importance of the microenvironment via the release of EVs.

show abstract

“…Dietary intake and nutritional supplements are important means for the body to obtain nutrients and maintain normal functioning. The association between micronutrient intake and disease has received widespread attention [27][28][29][30][31][32][33][34][35][36]. Micronutrients [29,30,32,36], which are essential compounds in human metabolism, play extremely important roles in metabolism, growth, development, and health [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

“…The association between micronutrient intake and disease has received widespread attention [27][28][29][30][31][32][33][34][35][36]. Micronutrients [29,30,32,36], which are essential compounds in human metabolism, play extremely important roles in metabolism, growth, development, and health [37][38][39]. Insufficient intake of certain vitamins or minerals can cause physiological disorders and diseases [40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Abnormal Micronutrient Intake Is Associated with the Risk of Periodontitis: A Dose–response Association Study Based on NHANES 2009–2014

Shang

Yang

et al. 2022

Nutrients

View full text Add to dashboard Cite

The association between micronutrient intake and the risk of periodontitis has received much attention in recent years. However, most studies focused on the linear relationship between them. This study aimed to explore the dose–response association between micronutrient intake and periodontitis. A total of 8959 participants who underwent a periodontal examination, and reported their micronutrient intake levels were derived from the US National Health and Nutrition Examination Survey (NHANES, 2009–2014) database. Logistic regression was performed to evaluate associations between micronutrient intake and periodontitis after propensity score matching (PSM), and restricted cubic splines (RCS) analysis was conducted to explore the dose–response associations. Following PSM, 5530 participants were included in the RCS analysis. The risk of periodontitis was reduced with sufficient intake of the following micronutrients: vitamin A, vitamin B1, vitamin B2, and vitamin E. In addition, the risk of periodontitis was increased with excessive intake of the following micronutrients: vitamin B1 (1.8 mg/day, males; 1.3 mg/day, females), vitamin C (90 mg/day, males), and copper (1.1 mg/day, combined). In conclusion, a linear association was found between vitamin A, vitamin B2, vitamin C, and copper and periodontitis—namely, a sufficient intake of vitamin A and vitamin B2 might help reduce the prevalence of periodontitis; by contrast, a high intake of vitamin C and copper increased the risk. In addition, a nonlinear dose–response association was found for the incidence of periodontitis with vitamin B1 and vitamin E. When within reasonable limits, supplemental intake helped reduce the prevalence of periodontitis, while excessive intake did not help significantly and might even increase the risk. However, confounding factors, such as health awareness, should still be considered.

show abstract

Dietary iron and vitamins in association with mortality

Cited by 15 publications

References 36 publications

Evaluation of Physicochemical Properties of Beetroot-Based Dietary Supplements

Evaluation of Physicochemical Properties of Beetroot-Based Dietary Supplements

Cross-Talk Between Mesenchymal Stromal Cells (MSCs) and Endothelial Progenitor Cells (EPCs) in Bone Regeneration

Abnormal Micronutrient Intake Is Associated with the Risk of Periodontitis: A Dose–response Association Study Based on NHANES 2009–2014

Contact Info

Product

Resources

About