Dietary intervention using (1,3)/(1,6)-β-glucan, a fungus-derived soluble prebiotic ameliorates high-fat diet-induced metabolic distress and alters beneficially the gut microbiota in mice model

Muthuramalingam, Karthika; Singh, Vishram; Choi, Chang‐Min; Choi, Seung In; Kim, Young Mee; Unno, Tatsuya; Cho, Moonjae

doi:10.1007/s00394-019-02110-5

Cited by 34 publications

(26 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we corroborate this nding: reduced abundance of Tenericutes in the MUO group compared with the metabolically healthy groups (MHO and Con). Similarly, in high fat diet-induced obese mice, β-glucan favorably increases bacteria that generate butyrate (such as Anaerostipes), thereby mitigating hepatic stress and intestinal atrophy [19]. In another study, gammaaminobutyric acid enriched rice bran ameliorated the metabolic syndrome (insulin resistance, lipids) in dietary-induced obese rats by enhancing Anaerostipes production of two salutary short-chain fatty acids, C2 butyrate and C3 propionate, and manifest both in the intestine and circulation.…”

Section: Discussionmentioning

confidence: 97%

Metabolically Healthy Obese Children and the Role of the Gut Microbiota

Chen¹,

McCormick²,

Zhang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator.Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic status, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6 and TNF-α, and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5-15 years) were divided into three groups: metabolically healthy obese (MHO, n=42), metabolic unhealthy obesity (MUO, n=23), and healthy normal weight controls (Con, n=21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO subgroup, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p<0.05).Conclusion Dysbiosis of gut microsystem prevails in the MHO cohort, and the abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds. As for a role in the etiology or facilitation of obesity- or perhaps vice versa- this childhood microbial imbalance awaits long-term, longitudinal investigation.

show abstract

Section: Discussionmentioning

confidence: 97%

Metabolically Healthy Obese Children and the Role of the Gut Microbiota

Chen¹,

McCormick²,

Zhang³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Coprobacillus is an important butyric acid producer and can be cross-fed with Anaerostipes, Roseburia, and Bifidobacterium to maintain butyric acid concentrations in the colon (Muthuramalingam et al, 2020). It affects intestinal function and mediates related intestinal diseases (Kassinen et al, 2007) through the inflammatory response (Shi et al, 2018;Seo et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Erchen Decoction on Gut Microbiota and Lipid Metabolism Disorders in Zucker Diabetic Fatty Rats

et al. 2021

View full text Add to dashboard Cite

Obesity is a chronic metabolic disease caused by genetic and environmental factors that has become a serious global health problem. There is evidence that gut microbiota is closely related to the occurrence and development of obesity. Erchen Decoction (ECD), a traditional Chinese medicine, has been widely used for clinical treatment and basic research of obesity and related metabolic diseases in recent years. It can significantly improve insulin resistance (IR) and lipid metabolism disorders. However, there is no microbiological study on its metabolic regulation. In this study, we investigated the effects of ECD on obesity, especially lipid metabolism and the composition and function of gut microbiota in Zucker diabetic fatty (ZDF) rats, and explored the correlation between the biomarkers of gut microbiota and metabolite and host phenotype. The results showed that ECD could reduce body weight, improve IR and lipid metabolism, and reduce the concentration of free fatty acids (FFA) released from white adipose tissue (WAT) due to excessive lipolysis by interfering with the insulin receptor substrate 1 (IRS1)/protein kinase B (AKT)/protein kinase A (PKA)/hormone-sensitive triglyceride lipase (HSL) signaling pathway in ZDF rats. Additionally, ECD gradually adjusted the overall structure of changed gut microbiota, reversed the relative abundance of six genera, and changed the function of gut microbiota by reducing the content of propionic acid, a metabolite of gut microbiota, in ZDF rats. A potentially close relationship between biomarkers, especially Prevotella, Blautia, and Holdemania, propionic acid and host phenotypes were demonstrated through correlation analysis. The results suggested that the beneficial effects of ECD on obesity, especially lipid metabolism disorders, are related to the regulation of gut microbiota in ZDF rats. This provides a basis for further research on the mechanism and clinical application of ECD to improve obesity via gut microbiota.

show abstract

“…β-glucan is a non-digestible dietary fiber found in many food sources including barley, oat, and yeast products [45]. β-glucans are found in the cell wall of an endosperm and are classified as glucose monomers connected by beta glycosidic bonds [46].…”

Section: β-Glucanmentioning

confidence: 99%

“…For example, in humans, acute 3 g β-glucan supplementation decreased hunger by 49% (−5761 ± 2944 vs. −3863 ± 2312, p < 0.05), increased satiety by 55% (3444 ± 1980 vs. 2221 ± 1375, p < 0.05) and decreased energy intake by 19% (−172 ± 8.5 kcal, p < 0.05), which was associated with decreased plasma ghrelin and increased PYY [55]. HFD-fed rodents supplemented with barley flour containing varying amounts of β-glucan exhibit reduced fat mass, body weight, cholesterol and increased insulin sensitivity, with some, but not all, studies finding a reduction in food intake [21,45,56,57]. Although not all studies directly show a decrease in food intake, given the rise in SCFA production and increase in the circulating gut peptides, PYY and GLP-1 observed following β-glucan supplementation [21,39,40,47,48,56], it is possible that β-glucan supplementation increases gut-brain signaling that regulates metabolic homeostasis.…”

Section: β-Glucanmentioning

confidence: 99%

Therapeutic Potential of Various Plant-Based Fibers to Improve Energy Homeostasis via the Gut Microbiota

2021

View full text Add to dashboard Cite

Obesity is due in part to increased consumption of a Western diet that is low in dietary fiber. Conversely, an increase in fiber supplementation to a diet can have various beneficial effects on metabolic homeostasis including weight loss and reduced adiposity. Fibers are extremely diverse in source and composition, such as high-amylose maize, β-glucan, wheat fiber, pectin, inulin-type fructans, and soluble corn fiber. Despite the heterogeneity of dietary fiber, most have been shown to play a role in alleviating obesity-related health issues, mainly by targeting and utilizing the properties of the gut microbiome. Reductions in body weight, adiposity, food intake, and markers of inflammation have all been reported with the consumption of various fibers, making them a promising treatment option for the obesity epidemic. This review will highlight the current findings on different plant-based fibers as a therapeutic dietary supplement to improve energy homeostasis via mechanisms of gut microbiota.

show abstract

Dietary intervention using (1,3)/(1,6)-β-glucan, a fungus-derived soluble prebiotic ameliorates high-fat diet-induced metabolic distress and alters beneficially the gut microbiota in mice model

Cited by 34 publications

References 47 publications

Metabolically Healthy Obese Children and the Role of the Gut Microbiota

Metabolically Healthy Obese Children and the Role of the Gut Microbiota

The Effects of Erchen Decoction on Gut Microbiota and Lipid Metabolism Disorders in Zucker Diabetic Fatty Rats

Therapeutic Potential of Various Plant-Based Fibers to Improve Energy Homeostasis via the Gut Microbiota

Contact Info

Product

Resources

About