Dietary intake of unsaturated fatty acids and age-related cognitive decline: A 8.5-year follow-up of the Italian Longitudinal Study on Aging

Solfrizzi, Vincenzo; Colacicco, Anna M.; D’Introno, Alessia; Capurso, Cristiano; Torres, Francesco; Rizzo, Caterina; Capurso, Antonio; Panza, Francesco

doi:10.1016/j.neurobiolaging.2005.09.026

Cited by 223 publications

(167 citation statements)

References 49 publications

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“…Setting The methods of the Italian Longitudinal Study on Aging (ILSA) and the 1st, 2nd, and 3rd survey data collection have been described in detail elsewhere (Solfrizzi et al 2004(Solfrizzi et al , 2006. A sample of 5,632 subjects aged 65-84 years, free-living or institutionalized, was randomly selected from the electoral rolls of eight Italian municipalities after stratification for age and gender.…”

Section: Methodsmentioning

confidence: 99%

Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging

Solfrizzi

Scafato

Frisardi

et al. 2011

AGE

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Cognition has already been considered as a component of frailty, and it has been demonstrated that it is associated with adverse health outcomes. We estimated the prevalence of frailty syndrome in an Italian older population and its predictive role on allcause mortality and disability in nondemented subjects and in demented patients. We evaluated 2,581 individuals recruited from the Italian Longitudinal Study on Aging, a population-based sample of 5,632 subjects, aged 65-84 years old. Participants received identical baseline evaluation at the 1st survey (1992)(1993) and were followed at 2nd (1995)(1996) and 3rd survey (2000)(2001). A phenotype of frailty according to partially modified measurement of Cardiovascular Health Study criteria was operationalized. The overall prevalence of frailty syndrome in this populationbased study was 7.6% (95% confidence interval (CI) 6.55-8.57). Frail individuals noncomorbid or nondisable were 9.1% and 39.3%, respectively, confirming an overlap but not concordance in the cooccurrence among these conditions. Frailty was associated with a significantly increased risk of allcause mortality over a 3-year follow-up (hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.52-2.60) and over a 7-year follow-up (HR 1.74, 95% CI 1.44-2.16), but with significant increased risk of disability only over a 3-year follow-up (HR 1.32, 95% CI 1.06-1.86 over a 3-year follow-up and HR 1.16, 95% CI 0.88-1.56 over a 7-year follow-up). Frail demented patients were at higher risk of all-cause mortality over 3-(HR 3.33, 95% CI 1.28-8.29) and 7-year follow-up periods (HR 1.89, 95% CI 1.10-3.44), but not of disability. Frailty syndrome was a short-term predictor of disability in nondemented older subjects and short-and long-term predictor of all-cause mortality in nondemented and demented patients.

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Section: Methodsmentioning

confidence: 99%

Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging

Solfrizzi

Scafato

Frisardi

et al. 2011

AGE

Self Cite

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“…A study found that the serum DHA levels of AD patients were significantly decreased when compared with healthy controls (Tully et al, 2003). High intake of -3 PUFAs from diet can lower the risk of AD and slow age-related cognitive decline (Morris et al, 2003;Solfrizzi et al, 2006). DHA and EPA are mainly obtained from deep-sea fish, which is the major dietary sources of -3 PUFAs of human.…”

Section: Diet Gut Microbiota and Admentioning

confidence: 99%

Alzheimer’s disease and gut microbiota

Wang

Jin

2016

Sci. China Life Sci.

296

188

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“…Intake of unsaturated FAs (both MUFAs and PUFAs) has been associated with improved cognitive performance and a decreased risk of age-related cognitive decline in long-term observational studies (14). Similarly, the intake of micronutrients such as vitamins C, E, and B-12; folate (15,16); flavonoids (17); and carotenes (16) has been associated with a decreased risk of cognitive decline and AD in human observational studies.…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Petersson

Philippou

2016

Advances in Nutrition

349

212

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A growing body of evidence suggests that adherence to the Mediterranean diet (MD) may protect against cognitive decline and dementia. Many epidemiologic studies and several randomized controlled trials (RCTs) have found positive effects of the MD on cognitive function, but findings remain inconsistent. The aim of this systematic review was to provide an update on the current knowledge of the effects of the MD on cognitive function, cognitive impairment, Alzheimer disease (AD), and all-type dementia. Five databases were searched-PubMed, Embase, CINAHL, CENTRAL, and PsycINFO (1806 to 25 May 2015)-with the use of prespecified criteria. Human studies that were published in English without any restriction on study type, population assessed, intervention period, follow-up time, or publication date, and that examined the association between adherence to the MD and cognitive function or dementia symptoms (as measured by cognitive function tests), were included. Only primary publication types were included. Thirty-two studies from 25 unique cohorts, including 5 RCTs and 27 observational studies, met the inclusion criteria. The majority of studies showed that the MD was associated with improved cognitive function, a decreased risk of cognitive impairment or decreased risk of dementia, or AD. Three studies found no correlation between the MD and AD, 3 further studies found no association between the MD and cognitive impairment, and 5 studies found no association between the MD and cognitive function. There was large heterogeneity, and studies differed with regard to quality. Based on the findings and the limitations in study design, we conclude that adherence to the MD is associated with better cognitive performance. However, it should be noted that the majority of findings come from epidemiologic studies that provide evidence for a correlation between the MD and cognition but not for a cause-and-effect relation. More controlled trials are required to establish a causational relation. Adv Nutr 2016;7:889-904.

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Dietary intake of unsaturated fatty acids and age-related cognitive decline: A 8.5-year follow-up of the Italian Longitudinal Study on Aging

Cited by 223 publications

References 49 publications

Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging

Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging

Alzheimer’s disease and gut microbiota

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

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