Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: Effect on the oral glucose tolerance of normoglycemic rats	 [pdf]

Eleazu, Chinedum; Ezekwibe, Ifeoma; Egbe, Mary; Saidu, Sanni; Eleazu, Kate; Egedigwe, Chima A.

doi:10.17306/j.afs.2017.2017.0460

Cited by 1 publication

(1 citation statement)

References 4 publications

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“…In case of increase in the liver weight, the absence of insulin production in diabetic group causes increased mobilization of fatty acids from the adipose tissue which gets accumulated in the liver and increases the weight of the organ (Eleazu et al, 2017). These results conforms that the treated diabetic groups had shown nontoxicity and had successfully prevented the enlargement of the organs in diabetic condition.…”

Section: Relative Organ Weightsupporting

confidence: 79%

Efficacy of Citrus maxima fruit segment supplemented paranthas in STZ induced diabetic rats

Karthiga

Sukhdeo

Lakshminarayan

et al. 2021

Journal of Food Science

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The study was conducted to investigate the efficacy of Citrus maxima (Pomelo) fruit segments fortified paranthas compared to pomelo juice and naringin in streptozotocin‐induced diabetic rats. The animals were divided into nine groups, Groups 1 to 3: negative control; Group 4: diabetic control; Groups 5 through 8: treatments with pomelo juice, naringin, plain paranthas, and pomelo supplemented paranthas; and Group 9 was positive control metformin. The groups were monitored for weight, oral glucose tolerance, insulin tolerance, bioavailability, biochemical parameters, and histopathological studies. Based on the result the group treated with paranthas fortified with pomelo fruit segment (Group 8) showed 19% of overall weight gain, approximately 50% reduction in plasma glucose level and improved serum protein (5.70 g/dl) and serum insulin (8.54 ng/ml) level as compared against diabetic control. The treatments had effectively lowered the level of liver enzyme and lipids (except HDL) in the serum along with the improved renal function. The group treated with pomelo juice and pomelo supplemented paranthas exhibited marked tolerance to the glucose and insulin similar to the positive control. Therefore, the antidiabetic activity was found to be more pronounced in the order of pomelo juice > fortified paranthas > naringin. Since pomelo juice is bitter and astringent in nature, the fruit can be better utilized in the form of fortified paranthas, which exerts antidiabetic effect similar to the positive control metformin. Hence, paranthas supplemented with pomelo fruit segments (bioactives‐rich) aids in the reducing the risk of diabetes and can be recommended to gain nutritional benefits for normal and diabetic populations.

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Section: Relative Organ Weightsupporting

confidence: 79%