“…The glycine receptor exists in a wide variety of cells, beside its typical occurrence at the postsynaptic neuronal membranes of the spinal cord. Besides endothelial cells and renal proximal tubular cells [17,41] , cells involved in inflammatory and immune responses, such as macrophages, monocytes, neutrophils, and T lymphocytes, express a glycine receptor [18,20,[42][43][44] . Glycine acts thru its receptor on inflammatory cells, such as Kupffer cells, to suppress activation of transcription factors and the formation of free radicals and inflammatory cytokines.…”