Dietary glutamine supplementation effects on amino acid metabolism, intestinal nutrient absorption capacity and antioxidant response of gilthead sea bream (Sparus aurata) juveniles

Coutinho, Filipe; Castro, Carolina; Rufino‐Palomares, Eva E.; Ordóñez-Grande, Borja; Gallardo, M.A.; Oliva-Teles, Aires; Perés, Helena

doi:10.1016/j.cbpa.2015.09.012

Cited by 43 publications

(30 citation statements)

References 61 publications

(88 reference statements)

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“…CAT, GR, SOD, and GSSG were higher in the intestine, while G6PDH and GPX activities were higher in the liver. Overall, LPO values were also considerably higher in the intestine than in the liver, which agrees with previously published data 48 . Higher intestine LPO and OSI values were expected due to the high enterocyte turnover rate that increases susceptibility to oxidation.…”

Section: Discussionsupporting

confidence: 92%

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Oxidative status and intestinal health of gilthead sea bream (Sparus aurata) juveniles fed diets with different ARA/EPA/DHA ratios

Magalhães

Guerreiro

Santos

et al. 2020

Sci Rep

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The present work assessed the effects of dietary ratios of essential fatty acids, arachidonic (ARA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), on liver and intestine oxidative status, intestinal histomorphology and gut microbiota of gilthead sea bream. Four isoproteic and isolipidic plant-based diets were formulated containing a vegetable oil blend as the main lipid source. Diets were supplemented with ARA/EPA/DHA levels (%DM) equivalent to:

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Section: Discussionsupporting

confidence: 92%

“…As already reported in gilthead sea bream juveniles 48,49 the antioxidant defense mechanism responded differently in liver and intestine. CAT, GR, SOD, and GSSG were higher in the intestine, while G6PDH and GPX activities were higher in the liver.…”

Section: Discussionsupporting

confidence: 76%

Oxidative status and intestinal health of gilthead sea bream (Sparus aurata) juveniles fed diets with different ARA/EPA/DHA ratios

Magalhães

Guerreiro

Santos

et al. 2020

Sci Rep

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“…On the other hand, while the intestine is a major consumer of GSH, the liver is thought to be the main organ for GSH synthesis and export (39,40). Moreover, as the liver is among the main lipid storage organ in sea bass, it may be more at risk from lipid peroxidative attack than the intestine.…”

Section: Discussionmentioning

confidence: 99%

Chlorella sp. and Nannochloropsis sp. Inclusion in Plant-Based Diets Modulate the Intestine and Liver Antioxidant Mechanisms of European Sea Bass Juveniles

Castro¹,

Coutinho²,

Iglesias³

et al. 2020

Front. Vet. Sci.

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This study aimed to evaluate the effects of including microalgae Chlorella sp. or Nannochloropsis sp. in plant-based diets on antioxidant mechanisms of European sea bass (Dicentrarchus labrax) juveniles. For this purpose, three isoproteic (50%) and isolipidic (19%) diets were formulated: a practical diet, containing 15% fish meal (FM) and plant ingredients as the protein source and a mixture of fish oil and vegetable oils (40: 60) as lipid source (control diet); and two diets identical to the control but with the FM replaced by Nannochloropsis sp. or Chlorella sp. (diets Nanno and Chlo, respectively). The diets were offered to quadruplicate groups of 25 fish (initial body weight: 24 ± 1 g) for 11 weeks and then enzymatic and non-enzymatic antioxidant mechanisms and lipid oxidative biomarkers were assessed in the liver and intestine of these fish. Results showed that the antioxidant response was tissue-dependent, with the liver exhibiting lower glutathione peroxidase and glucose-6-phosphate dehydrogenase (only in Chlo group) activities, and intestine lower superoxide dismutase activity with the diets including microalgae compared to control diet. An increase of oxidized glutathione content was also observed in the intestine of fish fed the microalgae diets. Catalase and glutathione reductase activities, oxidative stress index, and total and reduced glutathione, were unaffected by dietary treatments in both tissues. Overall, the lipid peroxidation status was not compromised by the replacement of FM by microalgae.

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“…; Coutinho et al . ). In the case of tryptophan, although there are many studies in different fish species focused on its nutritional requirements, role in behaviour, immunological properties or primary stress modulation (see the other sections of this review), very few reports are available about its effect on oxidative stress mitigation in fish (Akhtar et al .…”

Section: Antioxidant Capability Of Tryptophanmentioning

confidence: 97%

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

Hoseini

Pérez‐Jiménez

Costas

et al. 2017

Reviews in Aquaculture

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Tryptophan is an essential amino acid with a huge functional versatility, in addition to its participation in protein synthesis. Because of the complexity of its metabolism, and the functional relevance of several of its metabolites, it directly or indirectly participates in a wide array of physiological pathways. This amino acid is a precursor for the synthesis of the neurotransmitter/neuromodulator serotonin (5HT), the hormone melatonin and kynurenine and related compounds such as kynurenic acid, quinolinic acid or niacin. Because of this, it has a key role in the regulation of processes ranging from the neuroendocrine to the immune system in vertebrates. In aquaculture, extensive research has been performed to optimize the levels of tryptophan in the commercial diets for many fish species. Providing adequate levels of this amino acid is critically important for fish growth but also for fish welfare, as tryptophan has been shown to modulate fish behaviour, stress responses, and antioxidant and immune systems. Currently, available data suggest a wide variation in tryptophan requirements of different species ranging 0.3–1.3% of dietary protein level, but recent evidence also shows that fish tryptophan requirements can greatly vary depending on the rearing conditions of the fish. We also review here the participation of tryptophan and related metabolites in different physiological functions that are crucial for fish welfare. The review covers the involvement of tryptophan in 5HT‐ and melatonin‐mediated functions, along with its participation in the regulation of the immune system and its role as an antioxidant and antitoxic agent in fish.

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Dietary glutamine supplementation effects on amino acid metabolism, intestinal nutrient absorption capacity and antioxidant response of gilthead sea bream (Sparus aurata) juveniles

Cited by 43 publications

References 61 publications

Oxidative status and intestinal health of gilthead sea bream (Sparus aurata) juveniles fed diets with different ARA/EPA/DHA ratios

Oxidative status and intestinal health of gilthead sea bream (Sparus aurata) juveniles fed diets with different ARA/EPA/DHA ratios

Chlorella sp. and Nannochloropsis sp. Inclusion in Plant-Based Diets Modulate the Intestine and Liver Antioxidant Mechanisms of European Sea Bass Juveniles

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

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